ID   A0A6I8VZE9_DROPS        Unreviewed;      1063 AA.
AC   A0A6I8VZE9;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Nardilysin {ECO:0000313|RefSeq:XP_033236480.1};
GN   Name=LOC6902687 {ECO:0000313|RefSeq:XP_033236480.1};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_033236480.1};
RN   [1] {ECO:0000313|RefSeq:XP_033236480.1}
RP   IDENTIFICATION.
RC   STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_033236480.1};
RC   TISSUE=Whole body {ECO:0000313|RefSeq:XP_033236480.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261}.
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DR   RefSeq; XP_033236480.1; XM_033380589.1.
DR   AlphaFoldDB; A0A6I8VZE9; -.
DR   EnsemblMetazoa; FBtr0372658; FBpp0334600; FBgn0250407.
DR   KEGG; dpo:6902687; -.
DR   InParanoid; A0A6I8VZE9; -.
DR   Proteomes; UP000001819; Chromosome 4.
DR   ExpressionAtlas; A0A6I8VZE9; baseline.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          46..165
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          199..367
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          402..675
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   REGION          928..1026
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        932..1026
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1063 AA;  123499 MW;  12E51F4A0D96F12F CRC64;
     MAEVKHLEDP HKSENDRKMY KSLVLGNGLQ VLIVSAPSVG IGFPNNSSCA LMIDHGPFAD
     PCNYQGLAHL LQHMVFMGST PDSAENVFFA HVEKNGGECF SSIFSEDTLF SFTVPDEHLD
     SSLEYLMFSL KHPLMLQETM ERARALVDFQ FQQKVQKDVL RRNQLLASLA TDGYPHGSFN
     WGNMKSLKDK VDDSALHRAL HDAWRDNYAA NRMYVCLQGI MPIDVLENMV VRHFSKLRRN
     DIKAPDLTKF DYRNAFRPAF HEQVFLVKAV EKWRKFELTW VLPNMRQYYH SNPDKLLSYL
     IEYKGYGSLY AYLERRHWAH YLHAGIDETG FNLHSMHSFF KVDIGLTDEG FQHIDQVLSA
     TFAYLKVFSN CSSGSLRQLY EQQQKIKVAE FRLPDRIDKH DVDELVIKSK YYPPKDILTA
     RELYFDTDEQ HLSVLIGHLN SFKFNLMITS QEPFEGMPYD KREEWHGTEY TTLPMPAKWK
     KLWIESEPID ELFLPGANPF VAHDFKMFWN EQGKPTLPPY PKRLVKTDTC ELWFRQDDKF
     GKPKAYLCFF FITPLLSQSA KNAAMCDLYV SLVKAHVHKE MVLAKKANLS YCFMVYDNGL
     RLFVKGYNEK LHLIVEAIVE AMVSVGATLC ECLLTTYLEM QGESYLKLLK CPSQLATDIL
     ARVLGENPWA TIDQYKSLKD ITMEDLKVFA QKLPQEMYIK ALVQGNYTEE SAHKVLNSVL
     SRLKCEPIKD HRLVENRIVK LPQHCPVFCY DTACLHTTTT TITNFYQIGA NSLRVETILD
     LLNTLFNSPD LYLKKLGEEI NGWVHVKNGI VGYALTVNLK ETFEEDRAKQ MQNEIEVFRC
     KVCMIPMQME AKCFASWVDD LLHWELAPAL TLLDEVAENF REIIGGDYIF GRRQKKADVL
     RTLTKSDVIR FLFDTDWREL SIHVIGHQPS DTVDEEEDDV EDEGEDEDEY EYEEEDNVKE
     EGEDEDEYEY EEEGEDEDEY EEEDDVEEEG EDEDEYEEED DVEEEGEDED EYEEEDDVEE
     EDDVEYEVEY EYELEVMNSA ISEFRSGLEI YPKRSVEPCA EGN
//