ID A0A6I8W1M7_DROPS Unreviewed; 1390 AA.
AC A0A6I8W1M7;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Uncharacterized protein LOC26532738 isoform X1 {ECO:0000313|RefSeq:XP_033237250.1};
GN Name=LOC26532738 {ECO:0000313|RefSeq:XP_033237250.1};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_033237250.1};
RN [1] {ECO:0000313|RefSeq:XP_033237250.1}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_033237250.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_033237250.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR RefSeq; XP_033237250.1; XM_033381359.1.
DR EnsemblMetazoa; FBtr0376669; FBpp0337842; FBgn0271725.
DR KEGG; dpo:26532738; -.
DR InParanoid; A0A6I8W1M7; -.
DR Proteomes; UP000001819; Chromosome 5.
DR Bgee; FBgn0271725; Expressed in male reproductive system and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR46730:SF1; PLAT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02010; REJ; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1390
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5026261975"
FT TRANSMEM 1110..1132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1325..1345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1365..1386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 160..708
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1158..1275
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
SQ SEQUENCE 1390 AA; 161415 MW; 5C0DA223F65CE291 CRC64;
MWLPVDTIKL ILLSLHMTMQ VAENNELTRA KINIFTNEYV PYGRPTPIVI TMEELPVKYS
ITIHLSTSSY LLAFFEVGKV ANKMQPKFLK TLSISNQLSL LGIKARRKIM YDKGYFAKII
AIFWSANDKV ITLQGQLPSQ PWVHKVMEIV EVKVNLPTHC TPQIVILKGS DPQSPIKIAV
NRRFIIRVLF LETCNFTIRA SFRWHLTDAA ELKHFSKYFT DNPWLIIRRY SLRFQTKHEI
WRNLLVFHVE GNFNGFSFAS RCYLKLAMGQ VQAVIEGGES RRAAHNEILW INGSLSRDYS
KKYEVKQFST YNWNCDSWDD YSNPFCYHNI SSVDAFMIPA YSFKSGCSYI FRLLLADDDN
PNRGSLNVQT ITMTDYRMLQ VTIECLFNCE MDFFSPFSNV RLAARCTNCE TQTVRYQWYV
GGQLTLTSKD LNLYIRTVAN TSIVQLIVTA KDGWFGQDIK YLTKNSGPTI GKCFVKPTKG
QEALTPFFPC CKNFDTKNNP IEYWYYAGHV LLDNCYDCNC EVHLPVTNFI KVLACDSFQA
CRTSWIKVKV TALLNVPAQP PDILWKYITN SPHNILTLPE EGLLLRYFQT IQSIASHINH
IDSGLMLLRA LKGIYPQTRV SLGKLANLTL TLAHRLKPID AKEQHLLATV VKIMNNNFQR
LYHNDMIYLL IEQPLFDVTQ ACVTVYHMMN RMCKETPLPP KPIYVQYQLA LKSGKLVKGV
FDKLWAEINN FDDEQDKLRS LTWLRSTWET QRLFHYLGYA RQHGLKADTS GDSFYEGVAL
EIQCFSIERD QSYKIETSDS MHRVFFSSAL LKEVKENNKD YICLKVVSIK RELNWWYPEE
KQPSTILLSV RVFHYEEHFN VETVLKNSEI SFTTFIGNVE NESSSNMPRT TGLNSSKRLS
YLGWTSIGDA STRAAIHSYD ATVDSKHINC HEEGTIIKMQ DVRMYRIMLE EKTMLAVRFI
SSTHKLQVLL KTEVQPLFSD ISKSLCIVPA NSRNKTFLLR NNCMQGKRAY MAVRVWEKSP
LKSRLKTPVL DGPAKFDFVF EMRSCDYWLY SLPADEQHWA HDGCYPSLDF GVKKGMHCTC
KILGTYTSYV YNVPAIMVPV NPYAKVELNL IILLFYLLIT SFLLIWLLWF YLYRNIPISK
TVVCQMVDLE DDSAREVHDL LIHVKTGGRV NAETTSSVKL SLFSTQHHEM QFTLVQDPEH
LDLQRNTTYI LWLRTRDIRV PTKIAVSHNN AGRFPSWYLR RIEVNDVQTQ ETQVFVARRW
VKEKILILTS VLIFKPGDVR VVGTWKRRFR LNYEMLWTNW AMWQPITGKW RETNTFPSMS
RAKRFCVFIS KLVITYTICA CYFRPTTPDS LQLDRAKFLN FEDLIILSVI CSFVGLVMQL
IFEWLIRQYV
//
