ID A0A6J3QKT2_TURTR Unreviewed; 428 AA.
AC A0A6J3QKT2;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=Glial fibrillary acidic protein {ECO:0000256|ARBA:ARBA00018571};
GN Name=GFAP {ECO:0000313|RefSeq:XP_033703050.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_033703050.1};
RN [1] {ECO:0000313|RefSeq:XP_033703050.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_033703050.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: GFAP, a class-III intermediate filament, is a cell-specific
CC marker that, during the development of the central nervous system,
CC distinguishes astrocytes from other glial cells.
CC {ECO:0000256|ARBA:ARBA00002194}.
CC -!- SUBUNIT: Interacts with SYNM. {ECO:0000256|ARBA:ARBA00024375}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_033703050.1; XM_033847159.1.
DR AlphaFoldDB; A0A6J3QKT2; -.
DR Proteomes; UP000245320; Chromosome 20.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF9; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT DOMAIN 65..373
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 69..217
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 271..344
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 428 AA; 49388 MW; 4CD4C5FF692A4132 CRC64;
MERRRVTSAA RRSYVSSSEM GVGGRRLGPG TRLSLARMPP ALPARVDFSL AGALNSSFKE
TRASERAEMM ELNDRFASYI EKVRFLEQQN KALAAELNQL RAKEPTKLAD VYQAELRELR
LRLDQLTANS ARLEVERDNL AQDLGTLRQK LQDETNLRLE AENNLAAYRQ EADEATLGRL
DLERKTESLE EEIRFWRKIH EEEVRELQEQ LAQQQVHVEM DVAKPDLTAA LREIRTQYEA
VASSNIHEAE EWYRSKFADL TDAAARNAEL LRQAKHEAND YRRQLQALTC DLESLRGTNE
SLERQMREQD ERHAREAASY LEALARLEEE GQSLKDEMAR HLQEYQDLLS VKLALDIEIA
TYRKLLEGEE NRITIPVQTF SNLQIRETSL DTNSVTEGHL KRNIVVKTVE MRDGEVIKES
KQEHKDVM
//
