ID A0A6Q2WS62_ESOLU Unreviewed; 862 AA.
AC A0A6Q2WS62;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000043802.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000043802.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000043802.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC {ECO:0000256|ARBA:ARBA00007575}.
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DR AlphaFoldDB; A0A6Q2WS62; -.
DR Ensembl; ENSELUT00000081154.1; ENSELUP00000043802.1; ENSELUG00000008111.2.
DR GeneTree; ENSGT00390000018381; -.
DR Proteomes; UP000265140; LG03.
DR Bgee; ENSELUG00000008111; Expressed in liver and 14 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR013578; Peptidase_M16C_assoc.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR Pfam; PF08367; M16C_assoc; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SMART; SM01264; M16C_associated; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 495..745
FT /note="Peptidase M16C associated"
FT /evidence="ECO:0000259|SMART:SM01264"
FT REGION 792..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 862 AA; 97632 MW; E7F721C18705D2F0 CRC64;
SYVFHWSRNR ERLRANPSWR FRSTSATERA LQYQAGQKIH GFTVKEVFTV PDLFLTAVKL
THDNTGAQYL HAARDDKNNL FSVQFRTTPM DDTGVPHILE HTVLCGSQKY PCRDPFFKML
NRSLSTFMNA FTASDYTMYP FSTQNGKDFQ NLLSVYLDAV FFPCLRELDF WQEGWRLENE
NPTDPATPLA FKGVVFNEMK GAFSDNERVY AQHLQNKLFP DHTYGVVSGG EPLAIPDLTW
EQLKHFHATH YHPSNARFFT YGDLPLEQHL EQIQEEALSR FERTEPDTAV PSQPIWDQPV
SRFICPDAMS PDPAKQNTLC MSFLLGDITD TFESFTLSLL SSLMISGPNS PFYKALIEPK
IGSDFSSVVG YDGSTKEASF SIGLQGMAEE DIPKVKQIIV QTIDEIIANG FEEERIEAQL
HKIEIQMKHQ STSFGLSLAS YIASCWNHDG DPVQLLKISD SVTQFRQALK DNPRFLQEKV
LHYFKNNTHR LTLSMSPDEA YLEKQTKSEK EKLQKKIKAL SESDKKEIYE KGLELLSVQS
QTQDASCLPA LKVSDIEPTI SVTPVVMDTA GGVPVQYCEQ PTNGMVYFRA VCSLNTLPED
LKPYVPLFCS VITRMGCGRL DYRQQAQQME LKTGGMSVST SVHPDHSNMD MYEQGVLLSS
SCLERNLPDM FHLWSEIFNS PHFDDEERLR VLVMMSAQEL ANGISYSGHM YAMTRAARSL
TPTGELNETF GGMEQVRGGG WAMEIFRPVY IFCLRYMTTC GYLDRCAVNT TPQKVADAAG
QLDHFISGVA SNKKGRRPVR PDIAERPLDP LAAPGSGPSR KLIKEAHFKP CQMKTFFPMP
FPVNFVSHCI RTVPFTHEDY AR
//
