ID A0A6Q2WUK4_ESOLU Unreviewed; 867 AA.
AC A0A6Q2WUK4;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE SubName: Full=Solute carrier family 12 member 1 {ECO:0000313|Ensembl:ENSELUP00000044411.1};
GN Name=SLC12A1 {ECO:0000313|Ensembl:ENSELUP00000044411.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000044411.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000044411.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000044411.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A6Q2WUK4; -.
DR Ensembl; ENSELUT00000060166.1; ENSELUP00000044411.1; ENSELUG00000003881.2.
DR GeneTree; ENSGT00940000158030; -.
DR Proteomes; UP000265140; LG02.
DR Bgee; ENSELUG00000003881; Expressed in mesonephros and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01207; NAKCLTRNSPRT.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..539
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 572..656
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 661..867
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 867 AA; 95973 MW; 8E158D1ABB907545 CRC64;
MAEDGDSNHW ALPGDLESVL PQDNNVFVRF GWIKGVLVRC MLNIWGVMLF IRLSWVFGQA
GWGLGIVVIV LSCVVTTTTG LSMSAICTNG VVRGGGAYYL ISRSLGPEFG GSIGLIFAFA
NAVAVAMYVV GFAETVFDLL KENNAIILDQ TNDIRIIGCI TVVLLLGISV AGMEWEAKAQ
IVLLIILLVA IVNVFVGTVI PATPEKRSKG FFNYDAKVFM ENFTPDFREE NFFSVFAIFF
PAATGILAGA NISGDLKDPQ AAIPKGTLLA IFITGITYLG VALSATVVRD ATGNINNTIA
AGMNIVCNGS YAAACENGWD FSSCAVTKCS FGSMNNFQVM TMVSGFGPLI TAGTFSATLS
SALASLVSAP KVFQALCQDN IYTALKFFAK GHGKNNEPIR GYVLTFIIAV AFILIANLNV
IAPIISNFFL ASYALINFSC FHASYAKSPG WRPAYKYYNM WLSLFGAVLC CAVMFVINWW
AALITYAIEI FLYVYVTVKK PNVNWGSSTQ AVTFVSAVNN ALTLTGVEDH VKNFRPQCLV
LTGAPKNRPA LLDLTFYFNI NRFIILLILK HTHIIQSFYS AVVCDNFRQG AESLLQVSGL
GRLRPNILMM GFKKNWRTVD YADVQSYTGV LHDAFDFEYG TVLLRMTQGL DVSRQAVTVN
DRLMSINTQF QRKQGQGTID VWWLFDDGGL TLLLPYILTT RKKFKDCKMR IFIAGQPGRT
EQDKEEMKSL LVKFRIKCAE IHVIDDFNQK PSSYNWKVFE DMIEPFRLHE GSKSTTNAEA
LRKENTWKIS DAELDTFEEK TNLQVRLNEL LQENSRAANL IVVSMPIARL GSVSDYLYMA
WLDILTKNLP PTILIRGNHK SVLTFYS
//