ID A0A6Q2X272_ESOLU Unreviewed; 1093 AA.
AC A0A6Q2X272;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Solute carrier family 12 member 5 {ECO:0000313|Ensembl:ENSELUP00000047181.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000047181.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000047181.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000047181.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A6Q2X272; -.
DR Ensembl; ENSELUT00000086193.1; ENSELUP00000047181.1; ENSELUG00000001793.2.
DR GeneTree; ENSGT00940000165387; -.
DR OMA; MWRSFCD; -.
DR Proteomes; UP000265140; LG12.
DR Bgee; ENSELUG00000001793; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF54; SOLUTE CARRIER FAMILY 12 MEMBER 5; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 148..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 154..327
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 445..726
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 740..857
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 873..1093
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1093 AA; 121517 MW; F0297BA4C5234151 CRC64;
MSTFLQNKEL VILSSCDYRV FVVGWRRGDE FLVCLDCIHQ TQNFGNRRIR FVSTNNVGTL
LYFLKVCNAT AHFKDIDEPD SWSRQTDDAR RCNRERHDSV SALPKGRLVE VLSHHAPANS
CGKLSDREPN HGCWPENAFT SGTPAPSLGT LMGVYLPCIQ NIFGVILFLR MTWMVGIGGV
FGSFFIVFMC CSTTMLTAIS MSAIATNGVV PAGGSYYMIS RSLGPEFGGA VGICFYLGTT
FAGAMYILGA IELLLVYILP QAAIFKMEGL EGAEMEAAML NNMRVYGTIV LSFMATVVFV
GVKYVNKLAL VFLACVILSI LAVYAGVIKT AIEPPVFPVC ILGNRTLISK GFDVCAKVIE
QDNGTITTKL WRIFCDSEFL NATCDEYFAN NNVSEIQGIP GVTSGILAEN LFGYYLEKGD
FLEKRGLSAV QDQEVPITNS NRYVLADITS FFTLLVGIYF PSVTGIMAGS NRSGDLRNAQ
RSIPIGTIAA ITTTSTVCIL YNTTLQGSEM CLSNLRFGEG VNGNLVIGTL AWPSPWVIVI
GSFFSTCGAG LQSLTGAPRL LQAISRDSVI PFLKVFGQGK ANGEPTWALL LTASICEIGI
IIASLDAVAP ILSMFFLMCY MFVNLACALQ TLLRTPNWRP RFKFYHWALS FLGMSLCLSL
MFICSWYYAI VAMVIATCIY KYIEFAGAEK EWGDGIRGIS LSAARYALMR LEEGPPHTKN
WRPQILVLLS MDAEQNVEQP RLLSLTNQLK AGKGLTIVGT SVVGTFLNNH AEAQKAEQSL
RKLMETEKVK GFSQVVISSN LRDGTSHLIQ VGGLGGLKHN TVLVSWPRTW KRPEDNLRFR
NFIEVVRETT AASMALLVPK NIAAYPSNGE RFTEGHIDVW WIVHDGGMLM LLPFLLRQHK
VWRKCKMRIF TVAQMDDNSI QMKKDLITFL YHLRIDAEVE VVEMHDSDIS AYTYEKTLVM
EQRSQILKQM HLTKNEMERE VSPRGAATPG QEMQMTWTDK AENQAAACNH YQCLFCPVRN
QSNVRRMHTA LRLNEVIMKK SKEAKLVLLN MPGPPKNRMG EDNYMEFLEV LTEGLNRVLL
VRGGGREVIT IYS
//
