ID A0A6Q2XC01_ESOLU Unreviewed; 922 AA.
AC A0A6Q2XC01;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=PKD domain-containing protein {ECO:0000259|PROSITE:PS50093};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000050606.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000050606.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000050606.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; A0A6Q2XC01; -.
DR Ensembl; ENSELUT00000061238.1; ENSELUP00000050606.1; ENSELUG00000005412.2.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000265140; LG09.
DR Bgee; ENSELUG00000005412; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF10; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 884..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 622..667
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT COILED 821..848
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 922 AA; 103932 MW; DB85F17F9BCCECDD CRC64;
VAPSGELSQS SRLSLCLFSA DRTPIIKVIL ILTKLYDFHL GSVTESTLWR STDYGSTYER
MNDKVGSKTV LSYLYVCPSN KRKIMLLTDP EFERSVLISS DEGANYQKYR LSFYILSLLF
HPTQEDWALA YSHDQKVSSM SLFFCGGGVL HRVQYVTCRA LSCSEPNRNY PFPGYIDISS
LVVQDDYMFI QSPFPLCRKA SPKNDDLHIV STDEHQVFAA VQEWNQNDTY NLYLSDTRGI
FFTLALENVK TTRGLGGNQM LDLYEVAGIK GMLIANKRLD NQVKTYITYN KGRDWRLLQA
PGSDLAGNDI HCILPFCSLH LQLQTSENPY LSGSISTKAS APGIIVATGN IGSELSYNNV
GMFISSDAGN NWRQIFEEEH NIWFLDKGGA LVAVKQPTIP TRHLQISFDE GRQWTRHSFS
LVPLFVDGML VEAGTENQIM TFFGHFSHRS EWQLIKIDYK SIFNRKCTEG DYQTWHLHNK
GEPCVMGQKQ IYMKRRPGNY CMLGKDYAKV LSAESCICRA HDFECDYGYE RRADGNCLPA
FWYNPSAMSR NCSQGQDYLN STGYRKVVSN NCTNGVKEMY TPRKQLCPNR APRGLSLATR
EGKLTTNLAT NVTFLIHLDE LDFGDGTAVS YSNLSWIEEG IRHVYRTAGI FRVSALAENT
LGSDSAALYL HVTCPVEHVQ LLAPFVAIKN KEVNLTAVVW PNHSRTLTYF WWLGNSTEPV
ISIDGSISYT FTREGMNTVT VQVSSANTIL QDTKTIAVQE FFKSLLLSFS PNLDEYNPDI
PEWRQDVGRV IKKALLQVSD QLLVAVFPGV PTAAELFLLP HKNQSEDRKK SEEELEQISE
ILASALNQNL VDFELKPGAR VIVYVTQLTL APLVDSIPRH SSSAMLMLLS IVFLGLAVFL
IYKFKRGEPG ERAGDDRFGQ PK
//
