ID   A0A6Q2XUK4_ESOLU        Unreviewed;      1283 AA.
AC   A0A6Q2XUK4;
DT   02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Tetratricopeptide repeat domain 21B {ECO:0000313|Ensembl:ENSELUP00000057729.1};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000057729.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000057729.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000057729.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TTC21 family.
CC       {ECO:0000256|ARBA:ARBA00010935}.
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DR   Ensembl; ENSELUT00000083987.1; ENSELUP00000057729.1; ENSELUG00000020009.2.
DR   GeneTree; ENSGT00390000005979; -.
DR   Proteomes; UP000265140; LG16.
DR   Bgee; ENSELUG00000020009; Expressed in brain and 14 other cell types or tissues.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR040364; TTC21A/TTC21B.
DR   PANTHER; PTHR14699; STI2 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR14699:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 21B; 1.
DR   Pfam; PF13432; TPR_16; 2.
DR   Pfam; PF13174; TPR_6; 1.
DR   Pfam; PF13176; TPR_7; 1.
DR   SMART; SM00028; TPR; 16.
DR   SUPFAM; SSF81901; HCP-like; 1.
DR   SUPFAM; SSF48452; TPR-like; 4.
DR   PROSITE; PS50005; TPR; 4.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          306..339
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          704..737
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          738..771
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          930..963
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   COILED          222..249
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1283 AA;  146328 MW;  EE1E86517191840D CRC64;
     LFFDDVHALI YYYCHEKYFN HVLNAAATAQ RKFNDPIFSF FHAYGTLMQD QIPEAIHELE
     TIKDRRDVSL CTFMALLKLF VWIADRDVIQ ELDAKVKEDR KSATPKGLYY AGMFLWLLGR
     NDKAREYVER MIKISNGSRE GIILKGWIDL TSGKDSYAKK AGKYFDEGLR EKAEVFSLMG
     KAHYYEYRQN YSGALETVNQ VIVSFPGFLP AFIKKMTLLL ALQDWEQTID AAQRLLQRDK
     NNLAALRMLA LHSLCREGDI AESANQLSNL VSNLDAQEPH SPELFYKMSL AFTRVVRWIS
     YITVDSDLAT ELGYQLVLLG RIKEALKWYK TAMTLDETSV SALTGIIRCQ LIEGRLEDAE
     QQLEFLTEIQ QSIGKSGELL YLRAVLGVKK RRPQDEVTNL LNDAVDTHFS ALQGLPLGVD
     YFEKLNPDFL LEIVKEYIGL CPAKPPAQGQ PPAPQLQQCA SVLETVVKIV PGLIQGVFLL
     AKVRFQSGDI DSAQSSLQHC LDQCPSHAEA HLLMAQIHLS QGNFKLSSQS LELCLSHNFE
     VREHPMYHLI KAQTQKKTGQ LQEAIQTLQI AMMLPGVRRL GGSAKSKNKK VELSPADCVP
     VFLELAEALW LNGEQHEAAK VMQDAINEFS GTPEELCVTI ANADLALLRG DTELALSMLR
     NITPEQPYYI QAKEKMADIY LNHRKEKRLY ASCYRELVEK LPSPHTYLLL GDAYVNIQEP
     EKAIEIYEQA LKKNPKDGAL ASKIGKALVK THNYTKAITY YEAALKTEQQ NFLCYDLAEL
     LMKMRQYERC EKVLQDALAH DPVNELSALT NDCRYLVLLA KIQGKVDKND DALLSLDVQA
     KVLKRVQLEQ PDAVPAQKQL AAEICAEIAK HYTSIRGYER AVKFYKEALV YCESDSKVML
     ELARLYLSLD DVDGCQQQCS VLLKSDLVNE DATLMMADLM FRKQDYEQAV FHFQQLLERK
     PDNYPTLSRL IDLLRRAGKP EEVPRFLEMA EKHSSRAKFD PGFNYCKGLY LWLVCEPNDG
     LRHFNKARKD NEWGQNAVYN MIEICLNPDN DTMVTGSKSN QESEQLAVRT AEKLLKELKP
     QTASGHIQLR ILENYCFLAT KQKANVEKAL NVFTEIANNE KDHVPALLAM ATAYMILKQT
     PRARNQLKRI AKMNWSIVDA DEFEKSWLLL ADIYIQSGKY DMASDLLKRC LRHNKSCCKA
     YEYMGYIMEK EQAFRDAALN YEMAWKYGNQ TNPTIGYKLA FNYLKAKRYV DAIDVCHKVL
     DAHPNYPRMR KDILDKARAA LRS
//