ID   A0A6Q2XY70_ESOLU        Unreviewed;      1282 AA.
AC   A0A6Q2XY70;
DT   02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Tetratricopeptide repeat domain 21B {ECO:0000313|Ensembl:ENSELUP00000058949.1};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000058949.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000058949.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000058949.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TTC21 family.
CC       {ECO:0000256|ARBA:ARBA00010935}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   Ensembl; ENSELUT00000065271.1; ENSELUP00000058949.1; ENSELUG00000020009.2.
DR   GeneTree; ENSGT00390000005979; -.
DR   Proteomes; UP000265140; LG16.
DR   Bgee; ENSELUG00000020009; Expressed in brain and 14 other cell types or tissues.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 6.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR040364; TTC21A/TTC21B.
DR   PANTHER; PTHR14699; STI2 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR14699:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 21B; 1.
DR   Pfam; PF13432; TPR_16; 2.
DR   Pfam; PF13174; TPR_6; 1.
DR   Pfam; PF13176; TPR_7; 1.
DR   SMART; SM00028; TPR; 16.
DR   SUPFAM; SSF48452; TPR-like; 5.
DR   PROSITE; PS50005; TPR; 4.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          334..367
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          730..763
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          764..797
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          960..993
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   COILED          235..262
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1282 AA;  146046 MW;  5BB68A1BC406D263 CRC64;
     MCFFISKAVQ NSVFHILVFC FQALIYYYCH EKYFNHVLNA AATAQRKFND PIFSFFHAYG
     TLMQEAIHEL ETIKDRRDVS LCTFMALVYA EKKRPNPDRD VIQELDAKVK EDRKSATPKG
     LYYAGMFLWL LGRNDKAREY VERMIKISNG SREGIILKGW IDLTSGKDSY AKKAGKYFDE
     GLREKAEVFS LMGKAHYYEY RQNYSGALET VNQVIVSFPG FLPAFIKKMT LLLALQDWEQ
     TIDAAQRLLQ RDKNNLAALR MLALHSLCRE GDIAESANQL SNLVSNLDAQ EPHSPELFYK
     MSLAFTRVCG RNEKVIQQTH NMVDRAFSQA QVDSDLATEL GYQLVLLGRI KEALKWYKTA
     MTLDETSVSA LTGIIRCQLI EGRLEDAEQQ LEFLTEIQQS IGKSGELLYL RAVLGVKKRR
     PQDEVTNLLN DAVDTHFSAL QGLPLGVDYF EKLNPDFLLE IVKEYIGLCP PPAQGQPPAP
     QLQQCASVLE TVVKIVPGLI QGVFLLAKVR FQSGDIDSAQ SSLQHCLDQC PSHAEAHLLM
     AQIHLSQGNF KLSSQSLELC LSHNFEVREH PMYHLIKAQT QKKTGQLQEA IQTLQIAMML
     PGVRRLGGSA KSKNKKVELS PADCVPVFLE LAEALWLNGE QHEAAKVMQD AINEFSGTPE
     ELCVTIANAD LALLRGDTEL ALSMLRNITP EQPYYIQAKE KMADIYLNHR KEKRLYASCY
     RELVEKLPSP HTYLLLGDAY VNIQEPEKAI EIYEQALKKN PKDGALASKI GKALVKTHNY
     TKAITYYEAA LKTEQQNFLC YDLAELLMKM RQYERCEKVL QDALAHDPVN ELSALTNDCR
     YLVLLAKIQG KVDKNDDALL SLQRARDVQA KVLKRVQLEQ PDAVPAQKQL AAEICAEIAK
     HYTSIRGYER AVKFYKEALV YCESDSKVML ELARLYLSLD DVDGCQQQCS VLLKSDLVNE
     DATLMMADLM FRKQDYEQAV FHFQQLLERK PDNYPTLSRL IDLLRRAGKP EEVPRFLEMA
     EKHSSRAKFD PGFNYCKGLY LWYTGEPNDG LRHFNKARKD NEWGQNAVYN MIEICLNPDN
     DTMGGEVFEN LDGDIGNSTE KQESEQLAVR TAEKLLKELK PQTASGHIQL RILENYCFLA
     TKQKANVEKA LNVFTEIANN EKDHVPALLA MATAYMILKQ TPRARNQLKR IAKMNWSIVD
     ADEFEKSWLL LADIYIQSGK YDMASDLLKR CLRHNKSCCK AYEYMGYIME KEQAFRDAAL
     NYEMAWKYGN QTNPTIGKVW DI
//