ID A0A6Q2Y8M7_ESOLU Unreviewed; 2804 AA.
AC A0A6Q2Y8M7;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=E3 SUMO-protein ligase RanBP2 {ECO:0000313|Ensembl:ENSELUP00000062305.1};
GN Name=RANBP2 {ECO:0000313|Ensembl:ENSELUP00000062305.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000062305.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000062305.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000062305.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSELUT00000053708.1; ENSELUP00000062305.1; ENSELUG00000007763.2.
DR GeneTree; ENSGT00940000154389; -.
DR Proteomes; UP000265140; LG16.
DR Bgee; ENSELUG00000007763; Expressed in ovary and 15 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:InterPro.
DR GO; GO:0046907; P:intracellular transport; IEA:InterPro.
DR CDD; cd13177; RanBD2_RanBP2-like; 1.
DR CDD; cd13178; RanBD4_RanBP2-like; 1.
DR Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 4.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR InterPro; IPR022011; IR1-M.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR23138:SF169; E3 SUMO-PROTEIN LIGASE RANBP2; 1.
DR PANTHER; PTHR23138; RAN BINDING PROTEIN; 1.
DR Pfam; PF12185; IR1-M; 2.
DR Pfam; PF00160; Pro_isomerase; 1.
DR Pfam; PF00638; Ran_BP1; 4.
DR Pfam; PF00641; zf-RanBP; 4.
DR PRINTS; PR00153; CSAPPISMRASE.
DR SMART; SM00160; RanBD; 4.
DR SMART; SM00028; TPR; 1.
DR SMART; SM00547; ZnF_RBZ; 4.
DR SUPFAM; SSF50891; Cyclophilin-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 4.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50072; CSA_PPIASE_2; 1.
DR PROSITE; PS50196; RANBD1; 4.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 4.
DR PROSITE; PS50199; ZF_RANBP2_2; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT REPEAT 14..47
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1050..1186
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 1218..1247
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1321..1350
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1375..1404
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1418..1447
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1625..1761
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 1919..2056
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 2486..2621
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 2647..2803
FT /note="PPIase cyclophilin-type"
FT /evidence="ECO:0000259|PROSITE:PS50072"
FT REGION 954..977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1244..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1490..1521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1894..1914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2091..2121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2137..2169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 692..719
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1026..1053
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2103..2117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2154..2168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2804 AA; 310683 MW; B6552162A5EC7ED4 CRC64;
IHVSAYLTIA ERDPKAHKLL GQLYEREGDI NKAVGCYKRS VDLNPAQKDL VLKVAELLVS
KTERDSRAEF WVDKAAKLLP GNPAVFNLKE CLLNRQGQQG WNQLYDLLQA ELAVRPSDAH
INVKLVQLFS SDGRLEEAVK HCLATEKRGL LRSNLDWYST VVRTLQEFLA QPSVLSNEKT
SRCLHRELLL ARCSLLRLTL SGKGLQPSVE ALRSFDCAMQ GLRKAAPSVT DDLSEVYVEM
RGHLYLHAGT LLLKMAQERE QQWRAVVDLA ALCYLLAYQV PRPKTKVCKG EQSQPLELLA
SDRQSQAGHM LLNLNPNTHA FVREVVEAFG NRSGQGSLFE VLFGPQAPAG TSFIGNDDIR
SINTQAPEIS DLIKWDNGSI QLHGGDLQQL CWLGLQWSFL AQRPALRDWL KQLFPRLTLE
TSKLDTNAPE SICLLDLEVF LSGVVWCSHT QFQESAKISS TGQQHLHEPR CLPLPLLRLL
STDRQRDWWD AVYSLIHKRA APGMSAKLRM TVQHGLSTLR GGEKHGLQPA LPIHWAQQLS
STGLAVNSYY DQKDYIGRCV HYWKMVLPLL DKIKKKRSIP EPLDPMFIHF PSKVIQISSV
KCFEEEAMIA FAVLLDIEGK TEEAIATLEA INNISSNWHL ARVRSEAFSV FFFSFQSNSV
LIDLDLPCNS VRFPLVFNLS KEISPKTPPY WAEDQKSLLQ KLCQQVEALK NEVHDLRHNS
SDSLMSPRQR IYGEGYGAEG MQEGYPPPQA FHGAPLTVAT TQAPSMYFNQ STAYNSGQYL
LRTAANVTPT KAPVYGINRL PPQQHMYAYQ QPTNTPPLQS TPACIYTPQD QVFGAPLRFE
SPATSLLSPY SEEYYGHTQP TTNPPLPEPG YFTKPSVVPV QQPKSVEGKP VDFGKISFGQ
PIPAEPSKVP SFGAGVVAQS TPSAAFKFNS NFKSNDGDFT FKAKNSESLL GLLTSDMPSK
SESPSEGKLL DPPSQGGIFT FGTKSTAGLS FGDAALTQDK PNLFGKIDQP FSFTNVTKPI
FGLANRAEEE KGAESDNDST HVEEDEDGPH FEPIVPLPDK VDVKTGEEEE EEMFCNRAKL
FRFDAETKEW KERGIGLVKI LKHNTSGKVR LLMRREQVLK ICANHYITPD MLLKPNAGSD
KSWVWTAIDY ADEEPRTEQL AIRYKTSDEA LLFKMKFEEA QKIVPKSPKK QQDATDGKET
FQPSAPQETS FAAQFARKDG EWDCDVCCIR NVSTAMQCVA CQSTNPNAPT EPDSKPATKT
KGFTSGSASV GGFTFGFGAD SSKDSSCSGS FGKGFETTVE IQSKPSTVPF GSGFGAQFGK
KPGQWECNTC LVINEASASS CVSCQTPNPS AKSTVEVAPT PKPTVSGFGT LFAKKDGQWD
CDSCLVRNDA SATKCVSCQT PNPNASSTRS LGAMFAKQEG QWDCDTCLIR NEVSANQCIS
CQTPNPNAKS TATAAPSSSS FSFSFGSRSA STQPAGTGFK SNLNSGSTFQ FGTSKDDRSS
PASFKFETPP QSESSAPSAA GFSFTMPVPA GGFKFGIQEA AKETPPVDHV ENPLFTGKSS
DFSFADLAKN SQGDFQFGQS DPNFKGFTRA GEQLFSSLQS NQRSEISADQ DEEDVYKTEE
NDDIQFEPVV QMPEKVDLVT GEEDEQALYS QRVKLFRFDG ETSQWKERGV GVLKFLKNAT
NGRLRVLMRR EQVLKVCANH WITTTMNLKP LAGSDKAWMW LANDFSDGDA RLEQLAAKFK
TPELAEEFKL KFEECQRLLL DIPLQTPHKL VDTGRTAHLI QKAEEMKSGL KDLKSFLTDD
KTKIKEDDSR ANITTASNTS GLIIKPHAES TGPTLEWDNY DLREEALDDS ADTSVYASPL
ESSPIRKNLF RFGESTPGFN FSFQPVVSPA KSPAKLNKSG VSVDEEQDVT QEEERDGLYF
EPVVPLPDLV EISTGEENEN VCFSHRAKLY RYDKDLNQWK ERGIGDLKIL QNYDTKRVRL
VMRRDQVLKI CANHWVTSSM KLEPMKGAEK AWVWSAVDFA EIPEGNVEQL AVRFKLQDVA
NSFRDIFEKA KAAQENDILV TPITQNDAPS QVTTTGPSVC GKAAVAILEE TTRERTDSSP
EAFHTPDSRT ATPHTNLSKM IPPPKFLFGT DSLQKIFGNS PPSKEDGSSE SSKAKDSGRT
SQPSPAFKIP DKGTSIYPFS ILLTLWFSLN CLFLNGNPHD VLMSLCSSVT APPQAEADDD
DDDEVEVVYE RQPTADQAAL ARELLLPLTF FCYQNEPGYT SDDQTDDEDF ESAVKALLGK
LYQDLPERAL DPEIEVVWEK RPTPEEEQRA RTLQLPPTFF CGVSSDSETE KDKLEDFESE
LKTDVQSSTT DTPFSIQDEV QSSTAEADVP VLNTQKQFPE ESLTIQDPEV QSSTAEAPVP
VQSKLNSCLS FSEAPSPFGF SALGAGGFSF ADLAQNTGGE FAFGKQDSSF SWANAGATLF
GAAAPPKAEG EEEGSEEEDA NNVDIHFEPI VSLPEVETKS GEEDEEILFK ERTKLYRWDR
DLGQWKERGV GDMKILFHPE KRFYRVLMRR EQVLKVCANH TISQSMELKP MNTSNQALVW
TATDYAEGEG KVEQLAAKFK TAELAECFRK TFCECQSRIS QSEASSISSP QMSRVQEHSR
DTNPQVYLVI SADDVPLGRV TIELFSHIVP KTAENFRVLC TGQKGFGLHN SVFHRIVPDF
MCQGGDITKQ DGTGGRSIYG DKFEDENFDV RHTGPGLLSM ANRGRDTNNS QFFITLKKAE
HLDFKHVAFG FVREGMDVVR EMGELGTKTG KPSKKIVITE CGQL
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