ID A0A6Q2YAJ4_ESOLU Unreviewed; 1070 AA.
AC A0A6Q2YAJ4;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Solute carrier family 12 member 4 {ECO:0000313|Ensembl:ENSELUP00000062984.1};
GN Name=SLC12A4 {ECO:0000313|Ensembl:ENSELUP00000062984.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000062984.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000062984.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000062984.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A6Q2YAJ4; -.
DR Ensembl; ENSELUT00000044592.1; ENSELUP00000062984.1; ENSELUG00000005611.2.
DR GeneTree; ENSGT00940000157672; -.
DR Proteomes; UP000265140; LG02.
DR Bgee; ENSELUG00000005611; Expressed in liver and 15 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF46; SOLUTE CARRIER FAMILY 12 MEMBER 4; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 112..288
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 406..683
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 697..811
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 824..1070
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1070 AA; 119010 MW; FD587604AD59551F CRC64;
MTSYISICTI SYTCVVHKIL VGLFYVFLCS QSGIYTFPYP LQPPPFPAQY NPADLSHVSV
PQEELDIRPK VSSLLSRLVN YTNITQGAKE HEEAESTGML HVSPNMGTLM GVYLPCLQNI
FGVILFLRLT WIVGTAGIVQ SFFIVLMCCS CTMLTAISMS AIATNGVVPA GGAYFMISRS
LGAEFGGAVG ICFYLGTTFA AAMYILGAIE IFLKYLVPQA AIFHASDPHG GDSAILNNMR
VYGTICLSLM AVVVFVGVKY VNKLASLFLA CVIISIISIY AGAIKSIFQP PNFSICMLGN
RTLVRDQFDV CSKVVLDGNV TVPSQLWKNF CSSGNISSPQ CDDYFNQNNV TEIQGIPGLA
SGIIRDNMWG DYLEKGQILE KAGLPSVDVH GAVESIGLYV SADIATSFTL LVGIFFPSAT
GIMAGSNRSG DLKDAQKSIP IGTILAITTT TLVYFSSVVL FGACIEGTVL RDKFGDAVSK
NLVVGTLSWP SPWVIVIGSF FSTVGAGLQS LTGAPRLLQA IAKDNIIPFL RVFGHGKANG
EPTWALLLTG LIAELGILIA SLDMVAPILS MFFLMCYLFV NLACAVQTLL RTPNWRPRFK
YYHWALSFLG MSMCLALMFI SSWYYAIVAM CIAGMIYKYI EYQGAEKEWG DGIRGLSLSA
ARYALLRLEH GPPHTKNWRP QVLVLLKLDE DLHVKYPRLL TFVSQLKAGK GLTIVGSVIQ
GQFLDSYGET QAIKNMMEIE RVKGFCQVVV ASKVREGIAH LIQSCGLGGM KHNTVVMGWP
YGWRQSEDPR AWKTFINTVR CTTAAHLALM VPKNVSFYPS NHERFTEGTI DVWWIVHDGG
MLMLLPFLLK QHKVWRKCKM RIFTVAQMDD NSIQMKKDLA MFLYQLRIEA EVEVVEMHDS
DISAYTYERT LMMEQRSQML RQMRLSSAER EREAQLVKDR HSLVRMGSLY SDEEEEVVEH
EAEKIQMTWT KEKYEADRRN RNNAPENFRE LISLKPDQSN VRRMHTAVKL NEVIVNKSHD
ARLVLLNMPG PPRNTDGDEN YMEFLEVLTE GLERVLLVRG GGREVITIYS
//
