ID   A0A6Q2YDB3_ESOLU        Unreviewed;       587 AA.
AC   A0A6Q2YDB3;
DT   02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   SubName: Full=Poly(A)-specific ribonuclease {ECO:0000313|Ensembl:ENSELUP00000063401.1};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000063401.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000063401.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000063401.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CAF1 family.
CC       {ECO:0000256|ARBA:ARBA00008372}.
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DR   AlphaFoldDB; A0A6Q2YDB3; -.
DR   Ensembl; ENSELUT00000084209.1; ENSELUP00000063401.1; ENSELUG00000027101.1.
DR   GeneTree; ENSGT00940000153167; -.
DR   Proteomes; UP000265140; LG09.
DR   Bgee; ENSELUG00000027101; Expressed in ovary and 14 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR   CDD; cd12428; RRM_PARN; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 3.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR014789; PolyA-riboNase_RNA-binding.
DR   InterPro; IPR036867; R3H_dom_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR006941; RNase_CAF1.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR   PANTHER; PTHR15092:SF44; POLY(A)-SPECIFIC RIBONUCLEASE PARN; 1.
DR   Pfam; PF04857; CAF1; 2.
DR   Pfam; PF08675; RNA_bind; 1.
DR   SUPFAM; SSF82708; R3H domain; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          411..487
FT                   /note="Poly(A)-specific ribonuclease RNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF08675"
FT   REGION          144..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          520..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..166
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        526..558
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   587 AA;  67287 MW;  79321ED23813EC88 CRC64;
     MEVTRQNFKD SLTTVYSAIE EADFLAIDGE FSGISDGPNV SALTNGLDTP EERYMKLKKH
     SMDFLLFQFG LCTFTYDEAA SEYVIKTFNF YIFPKPFNRT SPDIKFICQS SSIDFLASQG
     FDFNKVFRHG IPYLNQEEEV QLREQYEERR NQSNGSGTTS YISPNANKGL GGVPEEHRDY
     IKRVMFPKGL HVETLETDKK ERYIQISKVD DEERKRRERQ KQEREQEELN DAVGFSRVIH
     AISKSGKLVV GHNMLLDVMH TIHQFYCVLP EVRGMLRNLH VSTHDAIFFL PHPQDLNDFK
     EVTQCVFPRL LDTKLMATTQ PFKELINNTS LAELQKQLKE SPFKPPKVVT AGGFPSYDTA
     QEQLHEAGYD AYITGLCFIS MANYLGKWRR FYGELLFLMR IIDIPYLNIS GPDLQPKRDH
     VLYVTFPKEW KTSDLYQLFS AFGNIQVSWI DDTSAFVCLS QTDQVQIAMN TSRYAESYRI
     QTYAEYLQGR RHVRENQAQG SQSWGEDGWV KPHYAPVPGT AAGDYRSSSG KRSISPIQEE
     QAQTTPTDGW SGNTHTHTHP DQGSKKIKTD GMHTLEDGMF EVLLVTV
//