ID A0A6Q2YFW6_ESOLU Unreviewed; 966 AA.
AC A0A6Q2YFW6;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Solute carrier family 12 member 1 {ECO:0000313|Ensembl:ENSELUP00000064453.1};
GN Name=SLC12A1 {ECO:0000313|Ensembl:ENSELUP00000064453.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000064453.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000064453.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000064453.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A6Q2YFW6; -.
DR Ensembl; ENSELUT00000048079.1; ENSELUP00000064453.1; ENSELUG00000003881.2.
DR GeneTree; ENSGT00940000158030; -.
DR Proteomes; UP000265140; LG02.
DR Bgee; ENSELUG00000003881; Expressed in mesonephros and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 88..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..469
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 568..966
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 966 AA; 107092 MW; FD11FFBF3E95D2E9 CRC64;
MDGRGGGGGL CVSSAQHAPR KQPDEIQMRQ IRVQQQQVRI NVTMNGEISV PNMAEDGDSN
HWALPGDLES VLPQDNNVFV RFGWIKGVLV RCMLNIWGVM LFIRLSWVFG QAGWGLGIVV
IVLSCVVTTT TGLSMSAICT NGVVRGGGAY YLISRSLGPE FGGSIGLIFA FANAVAVAMY
VVGFAETVFD LLKENNAIIL DQTNDIRIIG CITVVLLLGI SVAGMEWEAK AQIVLLIILL
VAIVNVFVGT VIPATPEKRS KGFFNYDAKV FMENFTPDFR EENFFSVFAI FFPAATGILA
GANISGDLKD PQAAIPKGTL LAIFITGITY LGVALCVSAT VVRDATGNIN NTIAAGMNIV
CNGSYAAACE NGWDFSSCAV TKCSFGSMNN FQVMTMVSGF GPLITAGTFS ATLSSALASL
VSAPKVFQAL CQDNIYTALK FFAKGHGKNN EPIRGYVLTF IIAVAFILIG WRPAYKYYNM
WLSLFGAVLC CAVMFVINWW AALITYAIEI FLYVYVTVKK PNVNWGSSTQ AVTFVSAVNN
ALTLTGVEDH VKNFRPQCLV LTGAPKNRPA LLDLAHCFTK NYGLCLTCEV FVGQKTRTVT
DLNAGMEKNQ MWLNKKKRKA FYSAVVCDNF RQGAESLLQV SGLGRLRPNI LMMGFKKNWR
TVDYADVQSY TGVLHDAFDF EYGTVLLRMT QGLDVAHIIK AQEEFERGVQ EQKDLEKEQL
KEENKGKSIF RKSRKSSQQH LTPTVSVMAP QSRQAVTVND RLMSINTQFQ RKQGQGTIDV
WWLFDDGGLT LLLPYILTTR KKFKDCKMRI FIAGQPGRTE QDKEEMKSLL VKFRIKCAEI
HVIDDFNQKP SSYNWKVFED MIEPFRLHEG SKSTTNAEAL RKENTWKISD AELDTFEEKT
NLQVRLNELL QENSRAANLI VVSMPIARLG SVSDYLYMAW LDILTKNLPP TILIRGNHKS
VLTFYS
//
