ID A0A6Q2YPI3_ESOLU Unreviewed; 288 AA.
AC A0A6Q2YPI3;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=Prohibitin {ECO:0000256|RuleBase:RU366048};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000067954.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000067954.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000067954.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Protein with pleiotropic attributes mediated in a cell-
CC compartment- and tissue-specific manner, which include the plasma
CC membrane-associated cell signaling functions, mitochondrial chaperone,
CC and transcriptional co-regulator of transcription factors and sex
CC steroid hormones in the nucleus. {ECO:0000256|ARBA:ARBA00037479}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004273, ECO:0000256|RuleBase:RU366048}.
CC -!- SIMILARITY: Belongs to the prohibitin family.
CC {ECO:0000256|ARBA:ARBA00009658, ECO:0000256|RuleBase:RU366048}.
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DR AlphaFoldDB; A0A6Q2YPI3; -.
DR Ensembl; ENSELUT00000078278.1; ENSELUP00000067954.1; ENSELUG00000019449.2.
DR GeneTree; ENSGT00950000183070; -.
DR Proteomes; UP000265140; LG08.
DR Bgee; ENSELUG00000019449; Expressed in mesonephros and 15 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd03401; SPFH_prohibitin; 1.
DR Gene3D; 3.30.479.30; Band 7 domain; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR000163; Prohibitin.
DR PANTHER; PTHR23222; PROHIBITIN; 1.
DR PANTHER; PTHR23222:SF1; PROHIBITIN-2; 1.
DR Pfam; PF01145; Band_7; 1.
DR PRINTS; PR00679; PROHIBITIN.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00022792, ECO:0000256|RuleBase:RU366048};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792,
KW ECO:0000256|RuleBase:RU366048};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 48..210
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
SQ SEQUENCE 288 AA; 31769 MW; 684B57907B6A88C5 CRC64;
MANKEPSSFL ANLRDLAGRM SGAGGKGAGI GLKLLIGAGA LAYGVKEATF TVDGGQRAII
FNRIGGMQMD TVLSEGLHFR IPWIQYPIIY DIRARPRKIA SLTGSKDLQM INIGLRVLSR
PVASNLPAMY QQLGKDYDER VLPSIVNEVL KSVVAKFNAS QLITQRAQVS LLIRRELFER
AKDFNIILDD VAITELSFSR EYTAAVEAKQ VAQQEAQRAQ FYVEKAKQDQ RHKIIQAEGE
AEAAKMLGQA VTKNPGYLKL RRIRAAQAIA KTVSICHDNN VMVTQPQT
//
