ID   A0A6Q2Z8Y9_ESOLU        Unreviewed;      1002 AA.
AC   A0A6Q2Z8Y9;
DT   02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE   AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000074874.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000074874.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000074874.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC       of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC       {ECO:0000256|ARBA:ARBA00007575}.
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DR   AlphaFoldDB; A0A6Q2Z8Y9; -.
DR   Ensembl; ENSELUT00000064105.1; ENSELUP00000074874.1; ENSELUG00000008111.2.
DR   GeneTree; ENSGT00390000018381; -.
DR   Proteomes; UP000265140; LG03.
DR   Bgee; ENSELUG00000008111; Expressed in liver and 14 other cell types or tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR013578; Peptidase_M16C_assoc.
DR   PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR   PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR   Pfam; PF08367; M16C_assoc; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SMART; SM01264; M16C_associated; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          492..739
FT                   /note="Peptidase M16C associated"
FT                   /evidence="ECO:0000259|SMART:SM01264"
FT   REGION          283..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          790..811
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1002 AA;  112510 MW;  9C4A658258363E42 CRC64;
     MILFSLANAS VLGQNPSWRF RSTSATERAL QYQAGQKIHG FTVKEVFTVP DLFLTAVKLT
     HDNTGAQYLH AARDDKNNLF SVQFRTTPMD DTGVPHILEH TVLCGSQKYP CRDPFFKMLN
     RSLSTFMNAF TASDYTMYPF STQNGKDFQN LLSVYLDAVF FPCLRELDFW QEGWRLENEN
     PTDPATPLAF KGVVFNEMKG AFSDNERVYA QHLQNKLFPD HTYGVVSGGE PLAIPDLTWE
     QLKHFHATHY HPSNARFFTY GDLPLEQHLE QIQEEALSRF ERTEPDTAVP SQPIWDQPRE
     DHVTCSPDAM SPDPAKQNTL CMSFLLGDIT DTFESFTLSL LSSLMISGPN SPFYKALIEP
     KIGSDFSSVV GTKEASFSIG LQGMAEEDIP KVKQIIVQTI DEIIANGFEE ERIEAQLHKI
     EIQMKHQSTS FGLSLASYIA SCWNHDGDPV QLLKISDSVT QFRQALKDNP RFLQEKVLHY
     FKNNTHRLTL SMSPDEAYLE KQTKSEKEKL QKKIKALSES DKKEIYEKGL ELLSVQSQTQ
     DASCLPALKV SDIEPTISVT PVVMDTAGGV PVQYCEQPTN GMVYFRAVCS LNTLPEDLKP
     YVPLFCSVIT RMGCGRLDYR QQAQQMELKT GGMSVSTSVH PDHSNMDMYE QGVLLSSSCL
     ERNLPDMFHL WSEIFNSPHF DDEERLRVLV MMSAQELANG ISYSGHMYAM TRAARSLTPT
     GELNETFGGM EQVKFMKRIA EMPDLTKVLR TLPRIKRHIL NPLNMRCAVN TTPQKVADAA
     GQLDHFISGV ASNKKGRRPH SYSGSLDPND LRPSTPCQMK TFFPMPFPVN FVSHCIRTVP
     FTHEDYASLN ILARMMTAKY LHGEIREKGG AYGGGARMGG GLFTFYSYRD PNSVQTLAAF
     RKGVDWARSG AFTQQDIDEA KLSVFSAVDS PVAPSDKGMG RFLTGITDEL KQAHRERLFA
     VTSKNIVDVA GRYLGIGQRT CGVAVLGPEN DTIRKDPSWV VK
//