ID A0A6Q2ZNS4_ESOLU Unreviewed; 1074 AA.
AC A0A6Q2ZNS4;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Solute carrier family 12 member 4 {ECO:0000313|Ensembl:ENSELUP00000079593.1};
GN Name=SLC12A4 {ECO:0000313|Ensembl:ENSELUP00000079593.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000079593.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000079593.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000079593.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A6Q2ZNS4; -.
DR Ensembl; ENSELUT00000050704.1; ENSELUP00000079593.1; ENSELUG00000005611.2.
DR GeneTree; ENSGT00940000157672; -.
DR Proteomes; UP000265140; LG02.
DR Bgee; ENSELUG00000005611; Expressed in liver and 15 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF46; SOLUTE CARRIER FAMILY 12 MEMBER 4; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 185..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 112..288
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 406..683
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 697..815
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 828..1074
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1074 AA; 119378 MW; 4DDB86E993916891 CRC64;
RVEVPRGTTF CLVLGHSQDV TETLLRTNGI YTFPYPLQPP PFPAQYNPAD LSHVSVPQEE
LDIRPKVSSL LSRLVNYTNI TQGAKEHEEA ESTGMSHMKA PKSPNMGTLM GVYLPCLQNI
FGVILFLRLT WIVGTAGIVQ SFFIVLMCCS CTMLTAISMS AIATNGVVPA GGAYFMISRS
LGAEFGGAVG ICFYLGTTFA AAMYILGAIE IFLKYLVPQA AIFHASDPHG GDSAILNNMR
VYGTICLSLM AVVVFVGVKY VNKLASLFLA CVIISIISIY AGAIKSIFQP PNFSICMLGN
RTLVRDQFDV CSKVVLDGNV TVPSQLWKNF CSSGNISSPQ CDDYFNQNNV TEIQGIPGLA
SGIIRDNMWG DYLEKGQILE KAGLPSVDVH GAVESIGLYV SADIATSFTL LVGIFFPSAT
GIMAGSNRSG DLKDAQKSIP IGTILAITTT TLVYFSSVVL FGACIEGTVL RDKFGDAVSK
NLVVGTLSWP SPWVIVIGSF FSTVGAGLQS LTGAPRLLQA IAKDNIIPFL RVFGHGKANG
EPTWALLLTG LIAELGILIA SLDMVAPILS MFFLMCYLFV NLACAVQTLL RTPNWRPRFK
YYHWALSFLG MSMCLALMFI SSWYYAIVAM CIAGMIYKYI EYQGAEKEWG DGIRGLSLSA
ARYALLRLEH GPPHTKNWRP QVLVLLKLDE DLHVKYPRLL TFVSQLKAGK GLTIVGSVIQ
GQFLDSYGET QASEQAIKNM MEIERVKGFC QVVVASKVRE GIAHLIQSCG LGGMKHNTVV
MGWPYGWRQS EDPRAWKTFI NTVRCTTAAH LALMVPKNVS FYPSNHERFT EGTIDVWWIV
HDGGMLMLLP FLLKQHKVWR KCKMRIFTVA QMDDNSIQMK KDLAMFLYQL RIEAEVEVVE
MHDSDISAYT YERTLMMEQR SQMLRQMRLS SAEREREAQL VKDRHSLVRM GSLYSDEEEE
VVEHEAEKIQ MTWTKEKYEA DRRNRNNAPE NFRELISLKP DQSNVRRMHT AVKLNEVIVN
KSHDARLVLL NMPGPPRNTD GDENYMEFLE VLTEGLERVL LVRGGGREVI TIYS
//
