ID A0A6S4FMF9_AEDAE Unreviewed; 257 AA.
AC A0A6S4FMF9;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=Procathepsin L3, putative {ECO:0000313|EnsemblMetazoa:AAEL002196-PE};
GN Name=5573901 {ECO:0000313|EnsemblMetazoa:AAEL002196-PE};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL002196-PE, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL002196-PE, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL002196-PE,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL002196-PE}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL002196-PE};
RG EnsemblMetazoa;
RL Submitted (AUG-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR AlphaFoldDB; A0A6S4FMF9; -.
DR EnsemblMetazoa; AAEL002196-RB; AAEL002196-PB; AAEL002196.
DR EnsemblMetazoa; AAEL002196-RD; AAEL002196-PD; AAEL002196.
DR EnsemblMetazoa; AAEL002196-RE; AAEL002196-PE; AAEL002196.
DR InParanoid; A0A6S4FMF9; -.
DR OrthoDB; 3434647at2759; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF995; CATHEPSIN K; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..257
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036190416"
FT DOMAIN 31..91
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 134..257
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 257 AA; 29220 MW; 976B189847D9D5F3 CRC64;
MKKQLLWILS ALIVAAGDIG ERVDEGDVTN FDTFLGAYQK KYKAKYRMDR RKRAFKKNMQ
EIEEHNANYE QGKSTFQMGV NELADMDKSS YLKKMVRMTD AIDHRKLDVD FNDEMLQATN
AFGEEFVQAT QNSMPDSLDW RDKGFTTMAV NQKTCGSCYA FSIGHALNGQ IMRRIGRVEY
VSTQQMVDCS TSAGNKGCAG GSLRFTMQYL QNSQGIMRSS DYPYTSSVSI IFRVLLVFLS
HFLQARAVSS RSISKKR
//
