ID A0ACI0_STRA7 Unreviewed; 6333 AA.
AC A0ACI0;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=Putative modular polyketide synthase {ECO:0000313|EMBL:CAJ88184.1};
DE SubName: Full=Type I polyketide synthase {ECO:0000313|EMBL:AKZ60162.1};
GN ORFNames=SAM23877_7119 {ECO:0000313|EMBL:AKZ60162.1}, SAMR0474
GN {ECO:0000313|EMBL:CAJ88184.1};
OS Streptomyces ambofaciens (strain ATCC 23877 / 3486 / DSM 40053 / JCM 4204 /
OS NBRC 12836 / NRRL B-2516).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=278992 {ECO:0000313|EMBL:CAJ88184.1};
RN [1] {ECO:0000313|EMBL:CAJ88184.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 23877 {ECO:0000313|EMBL:CAJ88184.1};
RA Barona-Gomez F., Lautru S., Francou F.X., Leblond P., Pernodet J.L.,
RA Challis G.L.;
RT "Multiple biosynthetic and uptake systems mediate siderophore-dependent
RT iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces
RT ambofaciens ATCC 23877.";
RL Microbiology (Mosc.) 152:3355-3366(2006).
RN [2] {ECO:0000313|EMBL:CAJ88184.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 23877 {ECO:0000313|EMBL:CAJ88184.1};
RX PubMed=16956972; DOI=10.1093/molbev/msl108;
RA Choulet F., Aigle B., Gallois A., Mangenot S., Gerbaud C., Truong C.,
RA Francou F.X., Fourrier C., Guerineau M., Decaris B., Barbe V.,
RA Pernodet J.L., Leblond P.;
RT "Evolution of the terminal regions of the Streptomyces linear chromosome.";
RL Mol. Biol. Evol. 23:2361-2369(2006).
RN [3] {ECO:0000313|Proteomes:UP000061018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23877 / 3486 / DSM 40053 / JCM 4204 / NBRC 12836 / NRRL
RC B-2516 {ECO:0000313|Proteomes:UP000061018};
RX PubMed=26410452; DOI=10.1016/j.jbiotec.2015.09.020;
RA Thibessard A., Haas D., Gerbaud C., Aigle B., Lautru S., Pernodet J.L.,
RA Leblond P.;
RT "Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
RT spiramycin producer.";
RL J. Biotechnol. 214:117-118(2015).
RN [4] {ECO:0000313|EMBL:AKZ60162.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23877 {ECO:0000313|EMBL:AKZ60162.1};
RA Thibessard A., Haas D., Gerbaud C., Aigle B., Lautru S., Pernodet J.-L.,
RA Leblond P.;
RT "Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
RT spiramycin producer.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP012382; AKZ60162.1; -; Genomic_DNA.
DR EMBL; AM238664; CAJ88184.1; -; Genomic_DNA.
DR RefSeq; WP_053141469.1; NZ_CP012382.1.
DR STRING; 1889.SAM40697_6418; -.
DR KEGG; samb:SAM23877_7119; -.
DR Proteomes; UP000061018; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 4.
DR CDD; cd00833; PKS; 4.
DR Gene3D; 3.30.70.3290; -; 4.
DR Gene3D; 3.40.47.10; -; 4.
DR Gene3D; 6.10.140.1830; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 4.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 4.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR036299; Polyketide_synth_docking_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 4.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 4.
DR Pfam; PF00109; ketoacyl-synt; 4.
DR Pfam; PF02801; Ketoacyl-synt_C; 4.
DR Pfam; PF08659; KR; 4.
DR Pfam; PF18369; PKS_DE; 3.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 4.
DR SMART; SM00822; PKS_KR; 4.
DR SMART; SM00825; PKS_KS; 4.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 3.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 4.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 8.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 4.
DR SUPFAM; SSF53901; Thiolase-like; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 4.
DR PROSITE; PS52004; KS3_2; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000061018};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 43..467
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1484..1559
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1585..2001
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2964..3042
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3063..3483
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4490..4565
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4586..5000
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5960..6035
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1450..1474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2667..2697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4445..4473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4999..5039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1454..1472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5005..5025
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6333 AA; 660337 MW; 2D7ACD3A3AB27E1B CRC64;
MPDETVGARA VSTEDKLRDY LKRVTTDLAS VRQRLRAAES TEHEPIAIIG MSCRFPGGAD
SPEALWRLVR DGIDAMGPFP ADRGWDMTHF ETGVAADVEF SREGGFLDGV ADFDPSLFNI
SPHEALAMDP QQRLMLETSW EAVERAGIDP LSLRGSRTGV FTGVMYNEYA SRIMSVPDEV
AGHLGTGNSG SVVSGRVAYT LGLEGPALTV DTACSSSLVA LHLAMRSLRS GESSLALAGG
VAIMVTPNTF FDFALSGGLA SDGRCKAFSA DADGTGWAEG VGVLLVERLS DAVRNGHEVL
AVVRGSAVNQ DGASSGLTAP NGPSQERVIR AALAAARLTA ADIDVVEAHG TGTTLGDPIE
AQALLNAYGQ DRPADRPLWL GSLKSNIGHT QAAAGAGGVI KMVQALRHGV LPRTLHADEP
TPHVDWSSGA VELLTQALEW PSGEQPRRAA VSSFGVSGTN AHVVLEEYRA PEPAAAPVEE
HGPGGSALPV LPWILSGRSR QALQGQAARL LSHLQEAGEE NAPAPMDIGF SCATTRATLE
HRAVVLAEDH AGFRRGLTAL AEGRETAEVI ARTQDPGQGG TVFVFPGQGS QWAGMAAELL
EREPVFAEAM AECASALEPF TDFSLLAVMR GEGVGLERVE VVQPVLWAVM VSLAKLWASV
GVVPSAVVGH SQGEIAAAVV AGGLSLEDGA RVVALRARAI ARELAGRGGM VSLAVPVVEA
EKLAARWPGL SVAAVNGPGS TVVSGEAAAV EELLAHCEAE GIRARRVPVD YASHCAQVER
IRERLLEDLA PIAPGSSAVP FHSTVTGVRM DTAGLNAEYW YGNLRNTVRF EEVTRALLTE
GRTLFLEISP HPGLSLGIGE SVEALGLRAS VLCTLRRGEG GVRRWLTAVA EAHVHGVRVD
WAAVYAGRGG TRVELPTYAF QRRRYWLDTL ELEPPAVDRP QDWFWSAVEQ EDLPALQRML
DVSGRTPLEE ALTALSAWHR RDRERSRIES WRYRTAWTPA ALPAGRLDGR WVVAVPPDHQ
AHPLVTAVSA ALAEAGAAPE PLPVSHRDER GALAERLRGA SGVLSLLFLA EGSVPEHPAT
PVAFAAALTL LHAVHDTGEP LRLWCATSGA VAAAPGDTVT HPDQALAWGL GRVAAHEYTQ
WGGLVDLPAA PEPRALARLA TVLAGTDEDQ TAIRATGIFV PRLRRAEPAA PRGMWRPSGT
VLVTGGTGGI GAHVARWLAA SGAEHLLLLS RRGPEAPGAK ELVAELRESG TDVTVAAVDA
ADHDALAAVL ADLPAAQPLT AVFHAAGIVD SSILDSLTPD RVETVLRAKV AGALTLHRAT
ADLDLSAFVL FSSLAGVFGS AGEGNYAPGN AFLDAFAQYR RAQGLVATSV AWGSWAGAGM
AEGDFGDVLE RHGIHRMEPE HALAGLRTAL EGDETTLALA DIRWDVFSWF FTATHPSRLL
DELPDVRKLR QPAQQGPAQG SAADQESLSP AQRLAGASEA ERNRFLLDLV RDQVALVLGY
ESGSEVEPGR ALGELGLTSA GAVELRNRLT FTTGLRISAT VVFDHPSPLA LARFLATEIT
GGSEDGVAEA AAAAVPGRDG TPVVDDPIVI VGMACRFPGG VRSPEDLWKL VESGTDAMGP
FPADRGWDLD ALGGDYPRTG GFLPDATDFD AELFGISPRE ALAMDPQQRL LLEASWEALE
RAGIHPRSLA GSRTAVYAGT GGQDYLAVLA GDPVAGEGYL VTGGSPSVLS GRVAYAFGLE
GPAVTVDTAC SSSLVALHLA CQSLRHQESD LALVGGVNVI SLPSVFAEFS KQRGQAADGR
CKAFSASADG AGWGEGVGVL LVERLSDARR RGHEVLAVVR GSAVNSDGAS NGLTAPNGPA
QQRVIRAALA SAGLEATDVD LVEAHGTGTR LGDPIEAEAL LATYGRDRSE PLYLGSVKSN
IGHTQAAAGV VGVIKAVMAL RHGVLPATLH VDEPTPEVDW SSGAVELLTE NRTWPEAGRP
RRAGVSSFGI SGTNAHTILE QAQETAKASV GARGERPDLP LPVALSGATP DALARQAALL
AGLDADTADL AHSLANTRAE LAHRAVVLGS HTAALTALAT SEHTQDAVSD KVVHGGLALL
FSGQGSQRSG MGRELYEAFP VFADAFDAVC ARVDLERPLR EVVFGEDAGL LERTVYAQAG
LFALEVALFR LVESWGVTPD VLVGHSIGEL AAAHCAGVLS LDDACALVSA RGRLMDALPE
GGAMLAVEVA EEGLELPDGV DLAAVNGPTS VTVSGEAEAI AELEERLRAQ GIRVKRLAVS
HAFHSRLMEP MLADFAAVAR SLTYHAPQIP VLTTAPGDLA TPEYWVGQVR EPVRFADALG
RLTGVRTALE LGPAGVLSAL AQEQDDTLVP VPALRPDRPE AATLVRAVAR LYTRGVPVDW
SSYLAPFEGA RVALPTYPFA RQRYWPEPVA AARPVAGENP AERDFWAAVD STDADAVAGA
LSLDDEQRDG LGAVLPALAA WRERSLHKAT TDAWRYRVGW SPVTDRQARL TGTWLLITGS
EVPGGLVDGL RGAGADLVEL TEPGTERAQC AERLARLASA AAERGRPVAG LLACVDTAAD
LLRLVQAQGD AGLAAPLWCL TSGAVAVAPG DVCEPSAAQL WGLGRVAALE HPDRWGGLVD
VPAHLDRRAA DRLVQLLAGA SGEDQAAVRP TGLHARRLRR APTGSPGQPR SAEWHADGPV
LLTGGTGALG GKVARLLAER GATRLVVASR RGPAAPGASD LVADLAERGC DAVVVPCDLS
DRGAVAELLE RHPVTAVVHA AGIVDDGVLD ALTPERLAAV LDAKAHSADA LDELTGELTD
FVVFSSVAGV IGSAGQGPYA AANAHLDALV ERRRARGLPG TALAWGAWAG AGMAADPAAA
ARLARGGLPG MAESRALEAL ATALTERDGA LVVADIDWER FVPGFTAVRQ SKLFAELPEA
VPVVRGVRAT VPVAPAAPGT DAAEQARHVE HLVLEAVAGV LGHGSPADVD RERAFHDMGF
DSLTALELRN LLAARTGLTL HAGLVFDFPT PGALAEHLLT SLSGGAAASD TPRAGDGGPA
ADDEPVAIIG MSCRFPGGVD SPEALWRLVR DGVDAMGDFP ADRGWDLDTL LGHDGPSHTR
SGGFLDDIAA FDAGLFGISP HEALAMDPQQ RMLLESAWEA FERAGIDPTS VRRSDTGVFA
GTNGQDYLAL LLGSAAATEG HLGTGNSASV LSGRISYTFG LRGPALSVDT ACSSSLVALH
LAARSLRAGE CSMALAGGVT AMPLPGTFIE FSTQGALSSD GRCKAFSADA DGTGWGEGVG
LLLLERLSDA ERNGHRVLAV VRGSAVNQDG ASNGLTAPNG PSQERVIRAA LADARLTAAE
VDAVEAHGTG TKLGDPIEAQ ALLATYGQGR EEPLYLGSVK SNIGHTQAAA GVAGVIKMVE
ALRHGVLPAT LHAREPSAQV DWSAGAVELL TDARRWPETD RPRRAGVSSF GMSGTNAHVI
LESAPQALDA TEEEPSDAGA VVPWLLSGRS GEALRGQAER LLAAGGGDPV DVGWSLATGR
ALLDQRAVLL GPDHATQLRA LVAAEEAAGV VRGGAVRGGT VFVFPGQGSQ WAGMAAELLD
AEPVFAARME QCRRALEPFT DFCPLEVVRG EGTALERVEV VQPVLWAVMV SLAELWTSAG
VAPSAVVGHS QGEIAAAVVA GALSLEDGAR VVALRARAIA DELAGCGGMV SLAVSREAAQ
ELTGRWEGLS VAAVNGPGST VVSGNVAGLE ALAAHCAAAG IRARRLPVDY ASHSAHVERL
RTRLLADLRD VDPAPSSVPF YSALTGGRID TSTLGAEYWY DNLRATVRFE DATRALLDDG
NRLLIEVSPH PVLTMGLRET LDDTDLPGAV LNTLRRGEGG RERWLTALAE AHVRGVGIDW
QRLLPEGRPV DLPTYAFDRD RYWPDPVEHA AGGRAGSPPG GTDQVEQAFW NDVERGDTPA
VARTLGLDVP GLDQVLPALA SWRRARHQEA TVDSRRYEVT WRPLVGLPTT TPTGRWLLAL
PQAGAEAETE TVRTALAHAE VTEVRVPADT GRSELAQELG QLPELGDFTG VVSLLALADR
PHPGDEVLAP GTGETVTLLQ ALGDVGIGAP LWCLTRGAVA VGRFDTAADC DRAMLWGLGR
VAALEHPERW GGLIDLCETA DARSAARLGA LLAGAAEDED QLAVRPSGVF SRRVRRAAPE
PVTTPWTPGG PVLVTGGTGA LGREVARWLA RRGVTDLLLV SRSGPEAPGT GELVAELAGL
GATAVVAACD VSDREALAAL LERHPVTGVV HTAGISTTAP LAGTSPAEIA DDVRAKVLGA
VHLDALLGDR ADLFVLFSSI AGVWGGGGQA AYAAANAHLD ALAEHRRAHG RTATAVAWGA
WDGSGMVADR EAGDYLRDRG ITPMPPQLCL AALASAVDSG RATGVFADVD WDRFVPTFTA
RRPSPLVGDL PEATTGRADA SEATAAADDR GQGRELRARL KAAGAADRHR LLLDLVRTVV
ATVLGHPGPR SVDPDRVFTE LGIDSLTALR VRDGLADATG LRLPATLVFD HPTARVAATE
LLTLLGAAEP APTQAPPRPA VRAEADDPVV IVSMSCRYPG GADSPENLWE VVAAGTDAMS
PFPVDRGWDL PDAGDFTTEG GFLHDATEFD ADLFGISPRE AVAMDPHQRL LLESAWELLE
RGGIAPTAVR GTRTGVFVGA SAGGYAMAGV LPEGSESHAM TGTSNSVLSG RVSYVFGLEG
PAVTVDTACS SSLVALHLAA QSLRNGECSM ALAGGVTVMH SPVVFAEFGR QGGLASDGRC
RSFAASADGT GWGEGVGLVL LERLSDARRN GHRVLGVVRG SAINQDGASN GLTAPNGPAQ
QRVIRAALAA AGLEAAEVDA VEAHGTGTKL GDPIEAQALL ATYGQDREEP LYLGSVKSNI
GHTQAASGIA GVIKTVEAIR RGVLPRTLHV DEPTPEVDWS AGAVELLTDD RPWPDTGRAR
RAGVSSFGIS GTNAHVLIEE APRETETETE TETETETETE TETETETETA PSPVGGPDTA
APLLLWPVSG RSEAALRAQA DRLRSHVDRA GATLDPRAVA HHLATARAAL EHRAVVLAPD
AEGLRRGLAG LAGAAGTEAG FVRGEAGRGD LAFVFSGQGA QRVGMGRELY ETYPVFADAF
DAVCAHLDPD LDRPLREVVL HDADALGRTA WTQLGLFAFE VALFRLLESW SVAPDRLAGH
SVGEVAAAHV AGVLSLADAC TLVAARGRLM GALPEGGAMM SVRMTEAEAH AALSGYEARA
AVAAVNSRDD VVLSGDADAL AELAEEAGRT GRTFRFLDVS HAFHSPRVDP VLDDFAAVVA
SLKYHPARIP LVSTVTGLPD DGAMSAPEYW VRQIRATVRF ADAVGALLDQ GVTRFAEIGP
GAALTVPLER TLERARSLDD TTGTLCVALQ RSGREEPAAL LTAVARLHTA GVPIGWDALL
GPVAGPRPDL PTYAFQRRRY WPEPHPAGAP HGTRTGRYQV TWRPLPEPEQ VVPQGTWLAV
TGGDRSAAGL LALLREQGMR VTEVPDAGGT REARAEALRR AYDDGPAVTG VLSLVAEPGD
VLALAQALGD IAADAPLWCL TTGAVATGPA DPPADPARAA VWGLGRTLGL EAPHRWGGLV
DLPAHPGPRT AARLAALLAA GGAGEDQIAL RATPVVRRLV TAPPVDAAPW RPSGTVLITG
GTGRRGRALA TALAANGAEH LVLLGRRGAE APDARAFAES LPVAVTFAAA DVTDRAAVTE
VLAAIPSDRP LTAVVHAVGA GEDTPWTELS PGDLRATAAA DGAQVLHDVT RELATEPEAF
VLVSSVTGVW GGTGAAVRAA ASARMDALAA HRHSLGLPAT SVSWGPWATG EGSAAARRHG
LRPLDPGTVW SSLREAVAGP APCVVVADVD WEHFHRAYTL ARHRPLFDEL PEVRALSAAV
RDAAPEPGAA PGLAGPDRHG AALDLVRGTA ATVLGHTDAA SVAPDRQFLE LGVDSLAALE
IRGTLERATG LSLPATVVFD HPTPAALARH LAATTAADGQ SPGSAVPAVT LGISPTDRNP
VGLLDSLYRE AVSTGRITEF LELVGQTAKF RPMADDVAEA GGPAALTTLA DGPASELLVC
VSGLTAGGGP QEFVRLAAPL RGARRVAAVP VLGYGRGELL PATPEVALDW QARGILAHAQ
DTPVVLFGHS GGAILAHRLA VRLADLGAPP AGLVLADVYR LDDPLMADWS AELSEGVFDR
AEQFVPMDDS RLTAMTWYGG LFWEIPRPDT RVPTLLLRAS EPLREPADGR DWRSSWKAAR
DIVDVPGNHF TMMAEHAGTT ARAVHRWIGE LPR
//
