ID A0B5W1_METTP Unreviewed; 452 AA.
AC A0B5W1;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit delta {ECO:0000256|HAMAP-Rule:MF_01135};
DE Short=ACDS complex subunit delta {ECO:0000256|HAMAP-Rule:MF_01135};
DE AltName: Full=Corrinoid/iron-sulfur component small subunit {ECO:0000256|HAMAP-Rule:MF_01135};
GN Name=cdhD {ECO:0000256|HAMAP-Rule:MF_01135};
GN OrderedLocusNames=Mthe_0288 {ECO:0000313|EMBL:ABK14085.1};
OS Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 /
OS PT) (Methanosaeta thermophila).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanotrichales; Methanotrichaceae; Methanothrix.
OX NCBI_TaxID=349307 {ECO:0000313|EMBL:ABK14085.1, ECO:0000313|Proteomes:UP000000674};
RN [1] {ECO:0000313|EMBL:ABK14085.1, ECO:0000313|Proteomes:UP000000674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6194 / JCM 14653 / NBRC 101360 / PT
RC {ECO:0000313|Proteomes:UP000000674};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Smith K.S., Ingram-Smith C., Richardson P.;
RT "Complete sequence of Methanosaeta thermophila PT.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of a complex that catalyzes the reversible cleavage of
CC acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains
CC the overall quaternary structure of the ACDS complex.
CC {ECO:0000256|HAMAP-Rule:MF_01135}.
CC -!- SUBUNIT: Heterodimer of delta and gamma chains. The ACDS complex is
CC made up of alpha, epsilon, beta, gamma and delta chains with a probable
CC stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
CC {ECO:0000256|HAMAP-Rule:MF_01135}.
CC -!- SIMILARITY: Belongs to the CdhD family. {ECO:0000256|HAMAP-
CC Rule:MF_01135}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000477; ABK14085.1; -; Genomic_DNA.
DR AlphaFoldDB; A0B5W1; -.
DR STRING; 349307.Mthe_0288; -.
DR KEGG; mtp:Mthe_0288; -.
DR HOGENOM; CLU_040403_0_0_2; -.
DR OrthoDB; 67748at2157; -.
DR Proteomes; UP000000674; Chromosome.
DR GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.20; Dihydropteroate synthase-like; 1.
DR HAMAP; MF_01135; CdhD; 1.
DR InterPro; IPR016041; Ac-CoA_synth_d_su_TIM-brl.
DR InterPro; IPR004486; CO_DH/Ac-CoA_synth_dsu.
DR InterPro; IPR011005; Dihydropteroate_synth-like_sf.
DR NCBIfam; TIGR00381; cdhD; 1.
DR PANTHER; PTHR36214; -; 1.
DR PANTHER; PTHR36214:SF5; ACETYL-COA DECARBONYLASE_SYNTHASE COMPLEX SUBUNIT DELTA; 1.
DR Pfam; PF03599; CdhD; 1.
DR SUPFAM; SSF51717; Dihydropteroate synthetase-like; 1.
PE 3: Inferred from homology;
KW Methanogenesis {ECO:0000256|ARBA:ARBA00022994};
KW Reference proteome {ECO:0000313|Proteomes:UP000000674}.
FT DOMAIN 129..379
FT /note="CO dehydrogenase/acetyl-CoA synthase delta subunit
FT TIM barrel"
FT /evidence="ECO:0000259|Pfam:PF03599"
SQ SEQUENCE 452 AA; 49213 MW; FBC4F5182FA9AAD8 CRC64;
MAEEKKIKLS DLNKTLAQYG VEALEGVSIE GDIEIEIDTG AAGIGPLFAY YFGQEVAQIA
VQLVKFARSM GYPVDALLQP AAVAHAISPA PAEVVEAAAK VPEWKVATSL VQAKFQVGID
ETWKYPIQEV TLGATKADGG SRGHTIKIGG EKALPFFYDA PMPHRPVVTM DVFDMPIGMA
KAVKMHYEDV INDPGEWAKK AVTKFGADLV TIHLISTDPL LKDTPPREAA KTVEEVLQAV
DVPICIGGSG NPDKDPEVLK AAAEVAQGER ALIASANLNM DWEKIGRACV DNGHVCLAWT
QLEINSQKEL NRKLMKVAGV PRESIVMDPT TAALAYGLDF AYTNMERIRL GALKGDEELT
FPMSSGTTNA WGVREAWMVR SPNKEDSDWG DRMLRGPIWE IITGFSLAMA GVDIFMMMHP
LAVAYLQEIT QTLMGLIDAE TPDITNWVKM EV
//
