ID   A0B6L6_METTP            Unreviewed;       375 AA.
AC   A0B6L6;
DT   28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2006, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   SubName: Full=Isocitrate dehydrogenase (NAD(+)) {ECO:0000313|EMBL:ABK14340.1};
DE            EC=1.1.1.41 {ECO:0000313|EMBL:ABK14340.1};
GN   OrderedLocusNames=Mthe_0549 {ECO:0000313|EMBL:ABK14340.1};
OS   Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 /
OS   PT) (Methanosaeta thermophila).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanotrichales; Methanotrichaceae; Methanothrix.
OX   NCBI_TaxID=349307 {ECO:0000313|EMBL:ABK14340.1, ECO:0000313|Proteomes:UP000000674};
RN   [1] {ECO:0000313|EMBL:ABK14340.1, ECO:0000313|Proteomes:UP000000674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6194 / JCM 14653 / NBRC 101360 / PT
RC   {ECO:0000313|Proteomes:UP000000674};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Smith K.S., Ingram-Smith C., Richardson P.;
RT   "Complete sequence of Methanosaeta thermophila PT.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR   EMBL; CP000477; ABK14340.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0B6L6; -.
DR   STRING; 349307.Mthe_0549; -.
DR   KEGG; mtp:Mthe_0549; -.
DR   HOGENOM; CLU_031953_0_1_2; -.
DR   Proteomes; UP000000674; Chromosome.
DR   GO; GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR   PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000313|EMBL:ABK14340.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000674}.
FT   DOMAIN          17..354
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   375 AA;  41802 MW;  0DAB9EA5E2E21078 CRC64;
     MKAAGDWIDY SSLKPLVIGY VDGDGIGPYI TGEAIRVLQS LLRDELERGD VEFRKIEGLS
     IEERARAMKA LPDDALDALK KCHVILKGPL TTPKKGDPWP NLESANVAMR RELDLFANVR
     PVSIPSEGID WVFFRENTEG EYVLGSKGFN VTDDLAVDFK VITTQGSERI IRLAFDYARR
     NNINRVSVVT KANVVKTTDG KFLEIARAIS KEYPEITFDD WFVDIMAAKL VDTKRRRDFR
     VIVLPNLYGD ILTDEAAEFQ GGVGTAGSAN IGKRYAMFEA IHGSAPRMVQ EGRAQYADPS
     SIMRASTMLL RHVGMIDKAR KLEMALDICG QFEKKLVMTG RPGGATGREF ADYVIETMNS
     DDLESRWLSY TGKGI
//