ID A0B924_METTP Unreviewed; 153 AA.
AC A0B924;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Transcription elongation factor Spt5 {ECO:0000256|HAMAP-Rule:MF_00950};
GN Name=spt5 {ECO:0000256|HAMAP-Rule:MF_00950};
GN OrderedLocusNames=Mthe_1423 {ECO:0000313|EMBL:ABK15198.1};
OS Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 /
OS PT) (Methanosaeta thermophila).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanotrichales; Methanotrichaceae; Methanothrix.
OX NCBI_TaxID=349307 {ECO:0000313|EMBL:ABK15198.1, ECO:0000313|Proteomes:UP000000674};
RN [1] {ECO:0000313|EMBL:ABK15198.1, ECO:0000313|Proteomes:UP000000674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6194 / JCM 14653 / NBRC 101360 / PT
RC {ECO:0000313|Proteomes:UP000000674};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Smith K.S., Ingram-Smith C., Richardson P.;
RT "Complete sequence of Methanosaeta thermophila PT.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Stimulates transcription elongation. {ECO:0000256|HAMAP-
CC Rule:MF_00950}.
CC -!- SUBUNIT: Heterodimer composed of Spt4 and Spt5. Interacts with RNA
CC polymerase (RNAP). {ECO:0000256|HAMAP-Rule:MF_00950}.
CC -!- SIMILARITY: Belongs to the SPT5 family.
CC {ECO:0000256|ARBA:ARBA00006956}.
CC -!- SIMILARITY: Belongs to the archaeal Spt5 family. {ECO:0000256|HAMAP-
CC Rule:MF_00950}.
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DR EMBL; CP000477; ABK15198.1; -; Genomic_DNA.
DR AlphaFoldDB; A0B924; -.
DR STRING; 349307.Mthe_1423; -.
DR KEGG; mtp:Mthe_1423; -.
DR HOGENOM; CLU_113589_0_0_2; -.
DR OrthoDB; 371863at2157; -.
DR Proteomes; UP000000674; Chromosome.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06091; KOW_NusG; 1.
DR CDD; cd09887; NGN_Arch; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR HAMAP; MF_00950; Spt5_arch; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR011590; Spt5_arc.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR NCBIfam; TIGR00405; KOW_elon_Spt5; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR SMART; SM00739; KOW; 1.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000674};
KW Ribonucleoprotein {ECO:0000313|EMBL:ABK15198.1};
KW Ribosomal protein {ECO:0000313|EMBL:ABK15198.1};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00950}; Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00950}.
FT DOMAIN 3..87
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 92..119
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
SQ SEQUENCE 153 AA; 16666 MW; 113BE8985E03CBF3 CRC64;
MSETSIYVVK TTANQERAVA NLVAQVARKE KLDIRAILVP DVLKGYVLVE ASAPEIVEQA
IQGVPHARSV IKGASSFAEI EHFLTPKPAV VGISEGAIVE LISGPFKGEM ARVKRVDIAK
EEITVELFEA MVPIPITVRG DHVRVLSKEE TQR
//
