ID A0BWZ2_PARTE Unreviewed; 227 AA.
AC A0BWZ2;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Autophagy-related protein 27 {ECO:0000256|ARBA:ARBA00013776};
GN ORFNames=GSPATT00032911001 {ECO:0000313|EMBL:CAK63059.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK63059.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK63059.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK63059.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004358}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004358}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Preautophagosomal structure membrane
CC {ECO:0000256|ARBA:ARBA00004472}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004472}.
CC -!- SIMILARITY: Belongs to the ATG27 family.
CC {ECO:0000256|ARBA:ARBA00005363}.
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DR EMBL; CT868023; CAK63059.1; -; Genomic_DNA.
DR RefSeq; XP_001430457.1; XM_001430420.1.
DR AlphaFoldDB; A0BWZ2; -.
DR EnsemblProtists; CAK63059; CAK63059; GSPATT00032911001.
DR GeneID; 5016241; -.
DR KEGG; ptm:GSPATT00032911001; -.
DR eggNOG; ENOG502SYEM; Eukaryota.
DR HOGENOM; CLU_1108871_0_0_1; -.
DR InParanoid; A0BWZ2; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.70.130.10; Mannose-6-phosphate receptor binding domain; 1.
DR InterPro; IPR018939; Autophagy-rel_prot_27.
DR InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom_sf.
DR InterPro; IPR044865; MRH_dom.
DR PANTHER; PTHR15071:SF0; CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR15071; MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER; 1.
DR Pfam; PF09451; ATG27; 1.
DR SUPFAM; SSF50911; Mannose 6-phosphate receptor domain; 1.
DR PROSITE; PS51914; MRH; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..227
FT /note="Autophagy-related protein 27"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013175187"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..155
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT REGION 192..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 227 AA; 25528 MW; 5422E64CB5C85E84 CRC64;
MISLLLVLQL TTILGCEFKQ EDHYYNLTQL QRTEPYIVKA SADSSFFKMA YQFNFCGNHP
KHCQGQSGAY QALEVMGILT DSCEILGKPE NQQMSLIENG LQITYSQGSQ CENNQKKSVN
FNILCSSEAD QNFVLLSEDN CRTAFQMKSP AGCKQQYSAQ PLFIYYLSGV GVMLMILGAC
FGYKQLQKKK DEKSDQYEKL NSDQPQAQNK NPDQSTTVVI NQEAPSS
//
