ID A0CIS1_PARTE Unreviewed; 3956 AA.
AC A0CIS1;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Chromosome undetermined scaffold_19, whole genome shotgun sequence {ECO:0000313|EMBL:CAK70688.1};
GN ORFNames=GSPATT00007823001 {ECO:0000313|EMBL:CAK70688.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK70688.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK70688.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK70688.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
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DR EMBL; CT868085; CAK70688.1; -; Genomic_DNA.
DR RefSeq; XP_001438085.1; XM_001438048.1.
DR STRING; 5888.A0CIS1; -.
DR EnsemblProtists; CAK70688; CAK70688; GSPATT00007823001.
DR GeneID; 5023870; -.
DR KEGG; ptm:GSPATT00007823001; -.
DR eggNOG; KOG0891; Eukaryota.
DR HOGENOM; CLU_224534_0_0_1; -.
DR InParanoid; A0CIS1; -.
DR OMA; PSPMCRE; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000000600}.
FT DOMAIN 3558..3879
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3924..3956
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT COILED 1908..1942
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3956 AA; 464563 MW; B64E4C980923D945 CRC64;
MNVLLEKELQ KLAAGNYQRA SDIKDSIENI LFENQLNHAE IGLCSSKIMA SEKSFLEFLT
NHVLDKDTYY AQTKKSLYQI LAKYIKNYVQ YVSEYLESII STCIQNFKKE ESGVAKEASL
LPIMKIYKHS DQQILVKLQV HKNLYHILLQ ECLETKLTAG VKGRIFQTLG VLIKRFNNDL
GEQGIYLHAF QSIISQIKSS KPEMVIIEGI LKFFKQCLMY HQFNQEQISL LYQALVTFCK
PVEDLSTFKV PIAACKCMKQ NLDIFSHYLI IKTNALTLFD QYIKILQHRN RDLKECVQEL
LELFIQKISQ QLDHSINDHK IIFNVILNKF IEILNDNKAD MFLMTVIIRS VGHFAKAIAN
LRGEKQLGDF FDKLNDLGFE RVLQVYEDFY KEEEGNMKRG AQFKVLLYRQ KQLNSFLISY
ANIIKNLSKI SDKQIQHLFA LCSLCIKQHY NYFENYRPYL YDGMANIIIS IFGHQTIGIQ
FVGSLLSKGV IEGLKLGQNQ LDGDLYIKTC QEMSKFWIGI IEQKVWTQHY LTKFVKQLFD
QIAQLIQNCN FESIQKEVNQ IDEQNQQQYT LKIQEFRNFA VNPTQLTQFH RFILMLSALI
PKIPIESAVI SILNLLNLVL IKIRKYPKAL LLLIFARVLL KYIKETQLIN QQFFEARQKQ
ILINLILKLK GLIQNHLKSY SSQLQIEALN VLLTIPVEFI VKDNYLLLKS EYIQIIINAF
QMNSNSLSWS AIDLLIQLIQ SEYNQKNQKN LKYLLKILKN VIPKLSSYMQ LVPEQEKPFY
TPIQYIDSIS PNILLSESHI DQNHIVDKVR YFLGSIGGLC HLIVDETYNE SLLALDYNSP
ITINIPVGQR KMKLRFGQFL ERILSLCLSA PLEKSKIYAC ELLQAFAIYM IGDQAVNGTK
AVAQNTKKKF EYANIYKKMF PVMIEISNTM DHPCRTYFKE HLTRIVHWFA NSKQYEAPDV
AQLLDCLFEQ PINKEDPQLE QFCSQLIGEF IQWTLKQTTP DQLKLNYSNI KTVMRRIITY
ANHPDFRYKS MSLECILQFV KHTQQEKFIV SKYFIEIVEQ LKFIFIVEDK DISRIVSNTN
NIIDIISNGF ERFTQDLLQE MKGRQGKNKT LYSLHEFLLN EAMIGKDGGW QQATLSLWYL
SVSKTQKVIK KNARELLVDQ IAEIGQKMKL FPKYPINRLQ GEQNYTSLRL DAESLSWQCR
IWQFIHDRNL FTLDEIIQFD DYLITTYNIH QFLRYFIVKN QKHLMDESPL FDMIMTLTQD
NFNPSQNFQN DAGNIDNWLA TSLPEKLVEQ LITTFERVYK FVRTFHIDVE QYYNLSIGII
IRPSYFLKGI QLDLYFGQVD SVVNEAQRLL QGTIKFTEFR QVLNEIFDNQ FVSFAQTITN
KDLIKDINEL KFFLKGLKWI SNQCSDDQDS NNFFQECIDQ LGQVVINFEQ GNDQINNIEY
VTHLFEFLLS EQRAKNFVIS NLIKASDFRQ KYEEQLIAFV ARNFESIGQI YFQYICKETH
LFRQGILLVN KVPQNQVHHF FKFQFKVNRE NSALLLLEIQ INNIVLNQTK NINREYVKGL
LKDGLNTGRS IEIHIDALIL FGLYIKHIDT DLPNYLNDLA NKYFPIKISD LKKGSAEELN
FKTILKKLTE MIKLCGQIQY IEVLFPLLRQ DLNFDLFIQE FLQINQESYQ QLKWLMLQIK
DEQLDTSTLN NVRIALGNKL LIPLLSNSNL LLEFYSEFTP YLLQQLNVTW DDNWKNMLFQ
LQWRGLIFDL FGIAYKRMST EQIKKQLHQN LKFQADNEIT KKLIVDCNKA SKFKFEKINI
LNINQKEILS QVNYLKIVED YQSSAFITYI YVLMKTQTKE NIFYAHLFKK ERDISYWDNF
INKEWQFNFQ VETNFEEKPL YTEVKKQQQD YFQEKIVKNY LYTASLSVEQ VTETTMEIEE
ENENLQSTVE VQKIEMDEVN KHKLMIPMLS LIDFMANKQN FQQQIAGQQQ TQQTQQQEEE
MPSWMTAIKQ VFNDDSLYLS LKIFMLKLII NKSDIFNRYA SGWIGVLLDY CTKENKINGG
KGFHYFLRDV IVVLIKFSQK LEVRQEYLQM HPQSRNKICS VINNLIMLSA DKNRKIFDQN
IEIIGMFVQL YRDSMYICDK SIVDMISKKP DQKNQQLDPQ AEDTSVLWQA NGLAILHIAL
LNNVVILQDY PEFVRTANSS LYEKYRFILQ KQSHNIKFPT EQINRLACTY TTKKHVLKGI
ANVYGSVLQC CQYLKVSGND YEQEIINIVT GIKADNRPGY GKEKFTTFMK ILTFVYPKVL
SNNKLFQETA NLIVQASNKE RAEILRIFSE FLEQIEQSTQ DPEFYINEIV VSISGSIDKV
IEDQEESVHY ALLNLLKQLV QLKCLNACTD LILHCFNQIL DKIDQKYGVD RDIGIVKIYQ
NILKLLHEYL INYDHKELQG KVTTYILSLF TSQHIEIRNL CFKYLQDDLE RKAIQLQYQA
GQQTTQIDRV ISLMKDIYQP SKETLWLKGA VPLLLSQSTK TQEYDAFMFD KNLSDEAHYY
DQEFNNKKYI RQNNMSQMAG TQFGSQFTSS SQLLSQAIGA SQNNPGNKNP VNQKQLIRAT
QEVIQQSQYF DEEGFRIPMK SNRSHLSQFL QANEISFQQI QLTSNNQIRY KPESATSLRD
PTKKYYKLKS QQPSSQMYTS TQEGFEKFVQ NRVRKYREGD LPDIKIKHKD IIDPLIVLCF
EDEELAGRVF TALFQELYDR NTSAETLYEV LLGLLQRSQC KTFIFISTVL RTLHQVLCKS
GILLPENKIV KKIGLESLAY YQSMILTEEC ILRLQEDNEN QEIRKSFFWM DLMDLHQSQG
NKAQIEGIIN ELFKDKPAFD SIKQAMDYKH QYSYVRANQQ LEELLDEINQ EGYDEDTIDG
RMVHYLQQEF EDTCMKLGQW EKLDAQLKDV TQLTDRELNA NLPLIRRTFH KYMSINKTGE
FDLQKAKYLE RRTEHLADEF LLEKTLILIS EQDIDQSRYF LQKAQRRFLT QWSSLLSQNE
LLSKQLRHKH LEQLQMMHEM GEIQSIYSGV EIDIDKKMQI LNTWAVRSPS LQDSLYTWNR
IYQNRLIMAN QTHPVLGMWA LQFAKGVVQM NYFQQAANLL SICFKIYKCE NWSTYSTLAK
LKLKEERFES DQRDLETIYQ KLNDNFDRYD QHKKLKLFFS QQAQKNTEKP VQFRFNMLPI
ISNQHYLKIN QDLVFMFNQE SRKHNNRYDF NPFYQRYADA IMQTFNGYLE LQIQLHDENI
NQSKFYNKAA MFCERCLRVI EPDSGGSNDL RKILENKNIS LDMIADQFVR YTISSFKFNA
NQLNKIETLL IKVLKVVQKF PNQIGPVFQD AVEKGHLSTW IFLQYLPQLI HLINDNVRFQ
YFKRIFDDFI KKYPQQFVYQ FNVTYQTRKE FKPDSEASKM FDKLHQCIPK NYAFIEALNQ
LTHPEHRLQA YLNQIKDNSE DIDTVIDKIQ EDFFSKREDF YGSYNLAFIQ KKKNQLNQIL
KNKADSHTIN QFAQEISEEA KQIQVKNQQM IHDMSRWFQN YNEESIDQVG KQTEILIPIQ
LSGMNEFDIQ MIPKIASFDQ GMLVLSSIRK PKRIKIYGTD EKQYLFLVKG GEDLRLDQRI
ELLFDVMNKI LPDSDLSTYG VFPMTKLFGM LQWVDNTTVI KEIIEKEHQE EEGLELFKNK
ALSKRDEYAA KAAKRQGQYN EKNKNFENAT DVVSNFNEQK KYVKDTLLRN GLSKLSANLE
AFVFIRDKFL INYAGICASG YILGIGDRHL ENILLNYSNG NLIAIDFGFS FGQGLALPIP
ELMPFRLTQV FEGLAKPIGL GGLYKSQFVK IMSALRKKRH ILLDFCEVFI NDPLIEQIKI
GKNKGMSDEF RQRLEEQSKI EEQVYNRTGD SPRNMKLIGV HCSLILLEEF DESRHQSARY
ADNLRKAIQG INQNRLRHQY QKHQTLSVIQ QVDCLIDLAT DPNILGRAWK GWAPFI
//
