ID A0CRF3_PARTE Unreviewed; 362 AA.
AC A0CRF3;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=GSPATT00009685001 {ECO:0000313|EMBL:CAK73370.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK73370.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK73370.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK73370.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; CT868152; CAK73370.1; -; Genomic_DNA.
DR RefSeq; XP_001440767.1; XM_001440730.1.
DR AlphaFoldDB; A0CRF3; -.
DR STRING; 5888.A0CRF3; -.
DR EnsemblProtists; CAK73370; CAK73370; GSPATT00009685001.
DR GeneID; 5026552; -.
DR KEGG; ptm:GSPATT00009685001; -.
DR eggNOG; KOG1684; Eukaryota.
DR HOGENOM; CLU_009834_22_1_1; -.
DR InParanoid; A0CRF3; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IBA:GO_Central.
DR GO; GO:0006574; P:valine catabolic process; IBA:GO_Central.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000000600}.
FT DOMAIN 22..352
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 362 AA; 40827 MW; 692A3A05F8B529C9 CRC64;
MRHIAKNNCI INKIKDGLST TYFNRLDKLN AVNLEMCEDI LESSKFWNEH AVVTILKGVG
NTFASGADYE HILNVPQNTN DLSNLSTNGQ LRDVSKFSLF GDQQKKAVHA IGSNKSITIS
IMNGPTSGIG AAFGINSRLK IATENTTFVM PHCKLGMVPD GGSALKFSKI YKNYGMYLGM
SGEQLDGLKM AHLGIADYLI DSECIPEIEM EIEQAHYLRD EESIKEFLLQ RYCYLNQTEF
EVPKQFLNVL SLSSLPSIMS AMEAQFPEQA AQIRKNSAFS VYAFYELFMR NKKAKLSLKD
NLKMEQSILD KVAARPDFVE GLRSLLVDTS YEPKFNPKTI EQVDLEEIQR CFEPCSRKLF
DD
//
