ID A0CV46_PARTE Unreviewed; 1237 AA.
AC A0CV46;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Chromosome undetermined scaffold_29, whole genome shotgun sequence {ECO:0000313|EMBL:CAK74663.1};
GN ORFNames=GSPATT00010831001 {ECO:0000313|EMBL:CAK74663.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK74663.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK74663.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK74663.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
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DR EMBL; CT868196; CAK74663.1; -; Genomic_DNA.
DR RefSeq; XP_001442060.1; XM_001442023.1.
DR AlphaFoldDB; A0CV46; -.
DR STRING; 5888.A0CV46; -.
DR EnsemblProtists; CAK74663; CAK74663; GSPATT00010831001.
DR GeneID; 5027845; -.
DR KEGG; ptm:GSPATT00010831001; -.
DR eggNOG; KOG0962; Eukaryota.
DR HOGENOM; CLU_267112_0_0_1; -.
DR InParanoid; A0CV46; -.
DR OMA; FSDYYYR; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0000794; C:condensed nuclear chromosome; IBA:GO_Central.
DR GO; GO:0030870; C:Mre11 complex; IBA:GO_Central.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003691; F:double-stranded telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0051880; F:G-quadruplex DNA binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0070192; P:chromosome organization involved in meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0032508; P:DNA duplex unwinding; IBA:GO_Central.
DR GO; GO:0006302; P:double-strand break repair; IBA:GO_Central.
DR GO; GO:0090304; P:nucleic acid metabolic process; IBA:GO_Central.
DR GO; GO:0000722; P:telomere maintenance via recombination; IBA:GO_Central.
DR GO; GO:0007004; P:telomere maintenance via telomerase; IBA:GO_Central.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 7..253
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT COILED 203..258
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 319..353
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 446..537
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 568..602
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 670..720
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 748..868
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 914..992
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1237 AA; 145758 MW; DB7E033FAF13DF5E CRC64;
MSSLLHLKLD GIRSYCHVGQ VKEDSRRAAQ QSQSIYFKQP LTLIWGHNGS GKTTIIEALR
TITTGMQPPN SEKGRSFLTD SHLLGQSKTD ACIELSFKSI NNREIVARRH FSIVYDSPNS
CKFSSLRSTL QTRSLETDKL ETLHSTCANI EKQIPCFLGV SVPILNNVLL CHQEEQLWMF
SDNSTLKGIF DELFETTDLV NIEVRLREQL KEAESKAKVL MEKVEFSKRD MDDGQRQRTN
LQNQLEEKIQ EIKVIQDINS QMNQIQISNI NFNIIQQRMS ECADLIACRN SIQENKLQLQ
LDHIDLNQLS QQDFVISSLK QLEIELKSSQ DTLKSTEINV ENKKIELQEL QVDTSIETLK
QEVKLIRDSI RSLFMFSNNI SDENLLKQVK EKISQNKLEQ QSEQQTQQET QSVFQTRISN
LNERKQKCLI EVRINENQRN EQLKLKEQMN KDIKNKELLL QQLTFQKRQA EQQEVQIKEK
LKLKQEFEQI NQDLIECYDI TQKNSQINSY QEIVKKISEL EENISSKSTQ IDLLIRENGW
RAMIKLNGSK LERDISISRC EESIKQKMQS IKTQMAKDQA QIKILNDQKE ELKNQLSINK
AIKYDPFELE NVKRQLREVK ENKIKYIFNQ TEFIDQYITS SKQSGKCLLC LKPTDQSCFE
LLKHRVQQNL PKTKSKINEF ELQINSLKAE KEKIKQGIQN NQHLEKIRQL DSQIAEIQAT
QRDSVANDSL LQLEKNLQDI TVLRQLLGNE EETQKEQLLI QKIQLEKENS FLKGSLKLSN
NPHNQSQLQK AKMDIQNKLK QYEGLQDNYE NPKQLQDSML RIQTELNQLR QQNQKIVIQD
FDDKSYEISQ IESQLNQLEL EQKLQYDQYM ESILNKKQLL NNLEAIQPQF EQKVLKKQDL
MNKSKNNYKY ADYIQKLQME IQAEADKMKQ LELDINQKQQ KLKQYQELQD YIQKLQKWQD
LDQAEEKLNE QIEILQQEIQ KLQDEYQSQQ LNISKKDKFR LEYDLRRSKL EQSFQSALEL
KKDINRRYDG SEQKRLEMLC EYVATQQFIS DLKKYLQILE ATMLECHGQK MKEINKYLLD
TWQKIYNGQD IKFIEVKFDE IPNQKKISKK YNYRLVMRTM NNTEIDMKGR CSMGQKMLAS
IVFRMALAEC FGSNCCFLAL DEPTSNLDRK HIKTLAEQLN SLIELMKQHE QQIQLIIITH
DMDLVKLLKR HSESYYMISK KENGFSGIEE RKIEELK
//
