ID   A0DAT4_PARTE            Unreviewed;       531 AA.
AC   A0DAT4;
DT   28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2006, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Tubulin--tyrosine ligase-like protein 5 {ECO:0000256|ARBA:ARBA00041448};
GN   ORFNames=GSPATT00015058001 {ECO:0000313|EMBL:CAK80151.1};
OS   Paramecium tetraurelia.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX   NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK80151.1, ECO:0000313|Proteomes:UP000000600};
RN   [1] {ECO:0000313|EMBL:CAK80151.1, ECO:0000313|Proteomes:UP000000600}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK80151.1,
RC   ECO:0000313|Proteomes:UP000000600};
RX   PubMed=17086204; DOI=10.1038/nature05230;
RG   Genoscope;
RA   Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA   Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA   Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA   Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA   Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA   Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA   Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA   Cohen J., Wincker P.;
RT   "Global trends of whole-genome duplications revealed by the ciliate
RT   Paramecium tetraurelia.";
RL   Nature 444:171-178(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L-
CC         glutamyl-L-glutamyl-[protein] + H(+) + phosphate;
CC         Xref=Rhea:RHEA:60144, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15517,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143622,
CC         ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036640};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60145;
CC         Evidence={ECO:0000256|ARBA:ARBA00036640};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CT868352; CAK80151.1; -; Genomic_DNA.
DR   RefSeq; XP_001447548.1; XM_001447511.1.
DR   AlphaFoldDB; A0DAT4; -.
DR   STRING; 5888.A0DAT4; -.
DR   EnsemblProtists; CAK80151; CAK80151; GSPATT00015058001.
DR   GeneID; 5033333; -.
DR   KEGG; ptm:GSPATT00015058001; -.
DR   eggNOG; KOG2157; Eukaryota.
DR   HOGENOM; CLU_010131_1_1_1; -.
DR   InParanoid; A0DAT4; -.
DR   OMA; ITCINPL; -.
DR   Proteomes; UP000000600; Partially assembled WGS sequence.
DR   GO; GO:0005929; C:cilium; IBA:GO_Central.
DR   GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR   GO; GO:0070740; F:tubulin-glutamic acid ligase activity; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   InterPro; IPR004344; TTL/TTLL_fam.
DR   PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR   PANTHER; PTHR12241:SF145; TUBULIN POLYGLUTAMYLASE TTLL5; 1.
DR   Pfam; PF03133; TTL; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   PROSITE; PS51221; TTL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000600}.
SQ   SEQUENCE   531 AA;  62044 MW;  C39AFDF9AD2090A2 CRC64;
     MNSPGDSIDD IISLLNKHYH PNCNQEQQSQ QNSRPKAGIG NVMLPQIKQQ LNVLSAIPNT
     YNNNSDKFKR KAASLNRQQQ PKSQTKDTNS FLIPMTRYLT FKPYSGSTDI IINDVGYYYK
     FGSSPIKLVK GLLEENGFKE NNDKNWTLYW SSCAIRSEIY TNLFAYQKVC HFPKSYEMTR
     KDLMHRNISK MQINHGFINF NFIPKTYILP AEMSYFLEEH EKIKNNNPVY ICKPHASSQG
     KGIFITDKIQ DILNKQNSNN SYVVSHYIDK PLLINNLKFD LRIYVAITCI NPLRIYVYQD
     GLARFATEAY NPDSVKQNRF VHLTNYSVNK DSPNFVANQD PTLDYLGSKW SLLALREYLK
     LNKINEQQIF ERIEDLIIKT IISVESAIFQ ACEMNVPFRS NCFSLFGFDV LVDQFLKPWL
     LEVNFSPSLN IDAPLDLKIK GEMLADLFTL IGIVPLDQRF SQDLSYVRNQ SNYDVKKHQQ
     EFEKYILKET EEEFKRSRGW KRLYPSDQSS RYSKYFESDR PLNALLRNYY K
//