ID A0DIP7_PARTE Unreviewed; 2574 AA.
AC A0DIP7;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE Short=PARP {ECO:0000256|RuleBase:RU362114};
DE EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
GN ORFNames=GSPATT00017271001 {ECO:0000313|EMBL:CAK82914.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK82914.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK82914.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK82914.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CT868452; CAK82914.1; -; Genomic_DNA.
DR RefSeq; XP_001450311.1; XM_001450274.1.
DR STRING; 5888.A0DIP7; -.
DR EnsemblProtists; CAK82914; CAK82914; GSPATT00017271001.
DR GeneID; 5036096; -.
DR KEGG; ptm:GSPATT00017271001; -.
DR eggNOG; KOG1037; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR HOGENOM; CLU_227826_0_0_1; -.
DR InParanoid; A0DIP7; -.
DR OMA; MCALEAR; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd01437; parp_like; 1.
DR CDD; cd07997; WGR_PARP; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR Gene3D; 1.20.142.10; Poly(ADP-ribose) polymerase, regulatory domain; 1.
DR Gene3D; 2.20.140.10; WGR domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR004102; Poly(ADP-ribose)pol_reg_dom.
DR InterPro; IPR036616; Poly(ADP-ribose)pol_reg_dom_sf.
DR InterPro; IPR036930; WGR_dom_sf.
DR InterPro; IPR008893; WGR_domain.
DR PANTHER; PTHR24125; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24125:SF5; REPEAT PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF02877; PARP_reg; 1.
DR Pfam; PF05406; WGR; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 18.
DR SMART; SM00773; WGR; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47587; Domain of poly(ADP-ribose) polymerase; 1.
DR SUPFAM; SSF142921; WGR domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 7.
DR PROSITE; PS51060; PARP_ALPHA_HD; 1.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS51977; WGR; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU362114};
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU362114};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362114}.
FT REPEAT 625..657
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 689..721
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 722..754
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 755..787
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 788..820
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1545..1573
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1765..1797
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 2039..2144
FT /note="WGR"
FT /evidence="ECO:0000259|PROSITE:PS51977"
FT DOMAIN 2172..2305
FT /note="PARP alpha-helical"
FT /evidence="ECO:0000259|PROSITE:PS51060"
FT DOMAIN 2315..2574
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT REGION 115..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1071..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1585..1618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..193
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1585..1602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2574 AA; 294728 MW; 9721B18683B3C0C5 CRC64;
MKTRGQKSEP QYAYQYKKDQ ILGQSEKGKP LLYKVVEDMK TNDHRSQLRV VKLEQQEKLK
DGKVVYKEAE ELLLPVKERT KVVDDVEVNS TKPNPRSKTA VTFFTFPQDT LQEIAKSMKQ
VPANTKQQKK QVSSESEDEE EEPPKKFTIK KGQKQQVEAQ PEKKVLKGKK QKQQKVEESD
QEDDEENEDE EEEEVVVKPS KKGSVQKQTK TKAENNQNQK VVQNQKQKIS KKQKKEESQE
SDQEDEEDEE PEVKNVVKKK QVKNTPAPKQ SQKVQDSSLI LKETRKRGRA QTQQEEEDEE
EDEEEEQSMS QSLSQSFSVD SKRKKGGKGS TTRKSKSQTN QPSKFVRGKV NPNYRDLRNI
SDQFEGPSSK FHDYTSVIMN NKELIRAART GNKKLLEDIF ANSQKISNLF TRWGPENEIN
ALELIFQRQD RVMLLLFVKS IGKIKLGVTP RCSLKEVNTG YNDKYAYGVR TRKVAMSRGG
REGNNAFVYD LNEEDHLGRY QIERLMKIET DPELFGLMIA QLGNEHSYYE LIAMAVRCGN
WRTAGYLVQQ AMEKGHMYGY NQVHVDVLNH TSASRIGNIK KASATKKTIG MYLITPIHCA
AINPNHGCLQ KLLDISQEFN ILDEIHRKPV HYAAVSQTND CLKYLLENGI DAREGDRQKN
TPLMLAAQHG RTHNVELLAA NNIGGKNKEG NAALHLACFG GHLETVKALL QHGALINQPG
ALRMTPLMIA SAYGHYDLVK YLIEQGAKVI SKDKFGRTSC AMAARNGNVR ILSLLLYYGA
EFNMPDSSKN TPLHYAAAYG FPECIEELMK AGADQNLPNS WKLTPLSVAL QKNHLGVVKT
LLNYPSTDVN CKDDEGRTLI SSSLSRFNAD SFEYMKYLIL EKSADVKIAD LQEKTPLHYA
VQISRKNVKQ YYQKWNEMTK AEKRDIKNNY EKLLGELIEL LINAGADVNV PDVNGQTPFI
QALMSQNFVT AEQIMKLATP KFDYIDNKDR NILHKLIECK LFLNPKGNTI LENVIKTVDQ
SYINQYDENG WNPLLYLISE YTKSAEQQHD KIYLKKVQQL QVKLFEQKVS ELPPEKDQID
EEKKHDEEAD QERDESKGEE HSDLEGSEEE DEEEIPFKKK QGAFKNPAFI PTKARTPAAT
NSYPGISVPA QPSQFGNQFG NQFGNQFGAS FGLFQQQQQF QQQQQQLTTT SGFGENVAHQ
RTFYYNSKPI IVHLTKEQVD VLKQETLQAS FLLQETVLKL FQQLINMGAK SNSVVIKRKK
FREPDATQQD VKEDPYISEG NYTIAHFVFK SFHSVSFLQG LQRISNISFK VATHNDIHPI
HLFVGTCNLF AICGREQETS QTFLKYVLNH IDIKVRDGNF NTPTSILASR YYEDLNWFIE
TLLENGGSID NLNKSNEVPL QKWVKANNIK IVELFLTKFK ADPNFKDKYK RTALHHAINS
SNSQADASFE MEHLLIMNGA DTSAIDFLQR TPIFYAFTKI NKHSEFSEID PFETVSSILA
DKNCSVNCLD FYKRSPLHYA ALRGSVISGR YMIKMNAVVD DVDKYGNTPL GLAFISGHSN
FCTMLIDNKA NVNRDAIVID REKVKQEEKR QRQERRDKGE EIETEDEGES NPVENDVNNN
AFNSGGMFFG NRLQPQGKVA TRSAFGQSNQ LNQLSQPTKF PAGTYSYFKL AIKQGWQGVA
YLLITDGYDL QRAIEDAMME DQFKLVRTLL LKVKEDSVVQ KYNQNHQNLF HIFAIKGRNC
GQDMAILIAD ELSRRGVDNL STDNQMNTPL HYACKNDFLQ MIKYFLHRNG DPNAFNSDKN
TPFSIRLQNN YKVFADFVEM GLWTSSNVNL NTKFKVNKKD YSLTPLLYLI QEYHVEDEIL
LTKFTDAGCD INEKTEKGET SLILAIKNNS MKLVNFILHH PKFKKEAHIQ DQNKRSPIHH
VVQPLEFGSY ENTEMLEVLG KIFDVNLIDS HGKTALDYAV DQDSGVMAGI LKNFSAVKNV
KSKQPRLPTS VISQAQWVEE EIDVEADAQK FLDLNGEQLD DSKQDFKNQV DQYAVLTGKL
EVLVDKEIGP YSLLMTKVDI GNGQYSENVF YKMQVLHEIN RNVYVLFTRW GRIGTGGQHQ
QTPFENSEEA IKEFNKIFQN KTGGNDWRKI KTGEEEFVKR PGKYQLMNVK KMKNYKTLLS
PFDFSKTSPY PPCKLDNTIK RFILQFIQVK LYQKDLQQFH VDMDFLPIER LDRKQLEVGK
AILNELTDSV EELKQLRQKG DLDIKKISNI SSEIADKSSR FYELIPMVEL RTEPLPPLDS
IEGINQKLLL IETLLNFEIT SKILLGAHLV KQSLNPLTYC FNALNVRVIT LHREHPEFKL
IDQYINQSST PKISNIFAIE RRGEAERFEN NKQHNRLLLW HGSKISNFMG ILAQGLKVAP
PWALNTGSMF GKGIYFADMF QKSFGYTDDW SLHYNAYNGL FQSGGGHWNR QQQVVKDEQE
EIQRYRYMLL CEVAVGKSQE LYQADNVQNL PQQYQSVKGC GRRGPDYKQS VILSNGCKVP
VGQCIDYPDP KKKDKDGNPI QYYLQHNEYI VYDETKVKFR YMVQLDTKDT VDEY
//
