ID A0DTL9_PARTE Unreviewed; 427 AA.
AC A0DTL9;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN ORFNames=GSPATT00020067001 {ECO:0000313|EMBL:CAK86386.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK86386.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK86386.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK86386.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107}.
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DR EMBL; CT868574; CAK86386.1; -; Genomic_DNA.
DR RefSeq; XP_001453783.1; XM_001453746.1.
DR AlphaFoldDB; A0DTL9; -.
DR STRING; 5888.A0DTL9; -.
DR EnsemblProtists; CAK86386; CAK86386; GSPATT00020067001.
DR GeneID; 5039568; -.
DR KEGG; ptm:GSPATT00020067001; -.
DR eggNOG; KOG2747; Eukaryota.
DR HOGENOM; CLU_011815_2_1_1; -.
DR InParanoid; A0DTL9; -.
DR OMA; ILCEVDK; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR025995; Tudor-knot.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR040706; Zf-MYST.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF215; HISTONE ACETYLTRANSFERASE OF THE MYST FAMILY 2; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR Pfam; PF17772; zf-MYST; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 140..417
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT REGION 98..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 321
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 427 AA; 50282 MW; 717745016B9B1C3A CRC64;
MSAKGKNKAK AFATLPNAVP TSSTKIHEGA LDNSNYVLAQ MKNGKWEKAK IIECRLSKDY
DPKQKKVDSS YEYYVHYEFY NRRMDEWVGR ERLQLTEDPI IEDTQPKKRP RPSDKREVTA
ENDEHEGMDQ QSLITHEMHT KFKTIEKIEF GQYRCDTWYY SPFPSGYHNI DCLLICEFCL
SFYIRKSELQ RHQLKCVLCK LGHPPGDEMY RDTERRLSMF EIDGHKNPTY CENLCYIAKL
FLDHKNLYYD VEPFLFFVLT EYNETGFHIV GYFSKEKESS QGWNLSCILT FPFHQRKGYG
KFLISMSYQL SLIEGKYGTP ERPLSDLGRE SYLSWWTQSI IDYLKKNKDG EITIAGLTKE
TGIKDTDAWW TLEQKHLIKY QQSQPLICMD MAYLDLIYSK AGRPGLPVKK DCIHWVPYKR
PKGQDKN
//
