ID A0DXR2_PARTE Unreviewed; 854 AA.
AC A0DXR2;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=GSPATT00021453001 {ECO:0000313|EMBL:CAK87829.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK87829.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK87829.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK87829.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
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DR EMBL; CT868640; CAK87829.1; -; Genomic_DNA.
DR RefSeq; XP_001455226.1; XM_001455189.1.
DR AlphaFoldDB; A0DXR2; -.
DR STRING; 5888.A0DXR2; -.
DR EnsemblProtists; CAK87829; CAK87829; GSPATT00021453001.
DR GeneID; 5041011; -.
DR KEGG; ptm:GSPATT00021453001; -.
DR eggNOG; KOG0519; Eukaryota.
DR HOGENOM; CLU_016833_0_0_1; -.
DR InParanoid; A0DXR2; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43719:SF28; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK2; 1.
DR PANTHER; PTHR43719; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 18..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 450..674
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 723..852
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 784
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 854 AA; 99833 MW; 170C7CC467D615D6 CRC64;
MGRAEKFRCL DNTNVKNLLI FFNSSIIFAQ IIENLIISRG PFIMTCLIFV LVMLIYQALS
FYFRAMRIQL IIYSQYFMLT LFSVELQIDT YFLIFQQLSI FDTVFFNRNE KNKIVQNILF
FGAIVINTYV FLRVGFHNLY FTDLIKALCQ SFLLKLLLYH FRQEHDVSLK EIQKLNNQEL
EPSDPRVGNV ECEPQDASKL FKTFDVVPEG IIILEKNGKE DFTIKYSNSA AKYLVDADDH
DQMLSELLDL RSVSPKQKSE EHLYKYSFSI QSQQSVKRNS FKIIPKQQSH IKSAFKISQQ
LILENQSSSQ KQEFQFPPVQ IIFPGAQTKT ENINHPNSPS IHYATQHKKS LDEIDSFHFL
LTQIWVQLHT LVKEKILNYQ NQPLYYIHES NPFVTNITKY QKKQCLDLKV YSAIHYNKPL
LVIILRDVNH KDYIKVLKDY NSQKSKTLSF VSHEFRTPLT CIIQMLEEVI ENRNNLNLSD
QQLIQSALDN SKYILNLSND LLDLAQIRAG KFKIRNAIFD LRSLLKECLK MFEIQAMKKN
IQLNYYYDMS LPTEIWSDLN RIRQITVNLI GNALKFTLEG SITLRAYQDG VNEICIEVKD
TGVGMREEDQ PKLFKAFAKI ENKEASQMNA QGVGLGLLIS NSIATQLNSE QRGLGFRSAY
QEGTTFCFLV TNNKSTYIDE IENYEDSRKD IDFDLETKLN DFRRQSQNEK KFILQKNYCA
CPQILLVEDN QFNVDSFLLK FHRTFKSLVK IDYTITGQLA EQKVQQRFLK QQHICHPYKL
IFMDVELPIQ NGIVTSKNIK NYYRAMNATV TIVGCSGYAE EKEKKECLQY MDDYIVKPVP
KQELERIMTS YFFK
//
