ID A0E682_PARTE Unreviewed; 1011 AA.
AC A0E682;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=Chromosome undetermined scaffold_8, whole genome shotgun sequence {ECO:0000313|EMBL:CAK90799.1};
GN ORFNames=GSPATT00003664001 {ECO:0000313|EMBL:CAK90799.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK90799.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK90799.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK90799.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GAPVD1 family.
CC {ECO:0000256|ARBA:ARBA00008489}.
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DR EMBL; CT868660; CAK90799.1; -; Genomic_DNA.
DR RefSeq; XP_001458196.1; XM_001458159.1.
DR AlphaFoldDB; A0E682; -.
DR STRING; 5888.A0E682; -.
DR EnsemblProtists; CAK90799; CAK90799; GSPATT00003664001.
DR GeneID; 5043981; -.
DR KEGG; ptm:GSPATT00003664001; -.
DR HOGENOM; CLU_297799_0_0_1; -.
DR InParanoid; A0E682; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030139; C:endocytic vesicle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF02204; VPS9; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000000600}.
FT DOMAIN 255..435
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 878..1011
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT COILED 42..69
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1011 AA; 118709 MW; A063F58687B2C9E4 CRC64;
MFEMQEDQSD VSIAQIKDSN HLKLSKRQSF NSDTILQWNC LQENLQLQYN LLNKENETKN
ERIQILLNTV EKYYKTQLRY KDLRRLYNQQ QTNNYNQIQC LLGYKFENVH FEIQKFLFLL
MENQELFAQL IHSSLDIGAH NLDEFIFDIL TFLYDPIVGA GLQEGVFKLL SELLKLELIN
LKNPLELFQD KTNLVCKFLI GFSKGPLCQS YIQQICGQAL NLLMNVKEEL ELNPKIIYEQ
QLKLKESKES AKLLKLKQEN KARKIMFNIL PILMQGTQEN KDINVYENVR RTKIPDSLLN
EIIEQISPSI QSYCQTPLQR LVDPQLVEET AKILYDRRKV TEMIVNSICD NIINSLHNLP
FIMRALFRLQ YQIFKVLYQS YKQEELFSLL IQFLINKWVL PEFTAMFLNQ QQLESSQYQT
NNIAVVSKIL LNVWKGEIIE GLKITLTSEN VLNYFKGLIE LPQTQLNFYI KEKTDKPFIS
YLLSISDLQI LLNSISKSRI DGSLGGKQLT RYTDLRELAE NIMRYNLKLG SDYMNNVVQW
KGQKVPANNM HFAVHRLSDL YNVNYIDIAF KFTEKFSAQD KEELLFISKA KQVVAQFLIS
IERISLLAKL RNNIILSFDN LIYMYKDSYE NKGQVIKQYE NISPQLYANY LLSIYKMIPN
QYTSNNLSLL CQEMIQEFDQ KVTYAKNQQK AMLEAFLKII TQLKTERNEI KSLNKMLKTI
ELKKKLTHFL KNIKIPCLLN FRHGQMNLIP IQDSSKTKSL DPKDNEKQQF LQIVNGADLN
QLQLELPFQS IRDFIDILSG LKHLQLALEG DQDYIEKVSK LFQNYMKLVE EKLQQQSFFP
QNQNLKKNNQ YVDLCFETVE KSIVRRIMMK YCTINEIKED QHFIEQCQQK LKHLEEQQEV
KICLSELPML QKMSESFRQI DQVMTPIEKL QMISDCLSNT TQLLKISGID DNPGQDGTLP
VFIYLVAQAC PKFMKTNLNI IQSLFNFDRW KNSTYPFSST QLQGAYENII N
//
