ID A0E8U0_PARTE Unreviewed; 2302 AA.
AC A0E8U0;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Chromosome undetermined scaffold_83, whole genome shotgun sequence {ECO:0000313|EMBL:CAK91707.1};
GN ORFNames=GSPATT00024438001 {ECO:0000313|EMBL:CAK91707.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK91707.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK91707.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK91707.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CT868664; CAK91707.1; -; Genomic_DNA.
DR RefSeq; XP_001459104.1; XM_001459067.1.
DR STRING; 5888.A0E8U0; -.
DR EnsemblProtists; CAK91707; CAK91707; GSPATT00024438001.
DR GeneID; 5044889; -.
DR KEGG; ptm:GSPATT00024438001; -.
DR eggNOG; KOG0206; Eukaryota.
DR eggNOG; KOG1023; Eukaryota.
DR eggNOG; KOG3619; Eukaryota.
DR HOGENOM; CLU_000619_1_0_1; -.
DR InParanoid; A0E8U0; -.
DR OMA; CHSARIG; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0045332; P:phospholipid translocation; IBA:GO_Central.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR032631; P-type_ATPase_N.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR PANTHER; PTHR24092:SF219; GUANYLATE CYCLASE ALPHA; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 66..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1036..1056
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1068..1088
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1116..1136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1156..1175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1182..1204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1224..1244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1353..1372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1378..1399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1406..1424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1430..1449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1461..1480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1492..1513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1901..1920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1926..1947
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1959..1978
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1984..2000
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2007..2027
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2033..2053
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1570..1705
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 2109..2240
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 2302 AA; 265734 MW; 87AA6164A6EF2768 CRC64;
MNYNHHQIVE KWLSRFRRCL SLCYPDDSQM ITMELHKGNV QLLSVPQNKN IFNTRKYTFL
NFLPKTLFTG LVRFGNIYLL AISLIMLIDP TLSPFYRWIT IFPIGLSVLL YVIIEFVLDI
RRQSHDHKIN MQTTSRGAKD GSIETIKWSD IQIGDVLYLI KGDIVPADII LLDTGQVRDR
EAICMVDTQY YDGKSSLTKK KSSYLTQLIV LRTRLKNQFP EYRKMLTGKL EYEAPNGNTQ
RFHARLKLKK DPKNEELTID NFIPKGTKIK QTSWLFGLAV YVGHNTKTMQ SSHYGAQKQS
FEEKQCNFYS FLMACLSLFF TLISIIVLLA RSDENSFALI IDSYTTNGMK VFQLAILYAQ
LIPATLYLLF DIVNFISVFK FEINQIEENL VKYVKINSSN NLCDLGHVDY MLIDKTGTLT
TSYYKLDNLL FGQLAFSLNY DQLQLTLNLK SAKQDDIEDP LKYASINDNN EYLIPFEYDK
KSNQTTEVQP SGKLLLKSVK TSNNNPIFNQ ITAQPISKRQ TFLNMDVQYQ QQIPDYSQTR
MFLPQPKHKN SPGNNNDEFM QLVNQLRNSS PQKEYLQTKD INTLYYDAFL KCLMLCHEAR
PVFGADSITY ESFSKNEEIS LTFARSCGYQ LENFNKFDSP DIYLCKVRGN SIWYQVLGLN
LFTYNRNLNS VVVQVPTTMD LELGQEHEAL NQLCGEGSKN KSLLICKGDY EAIKLKLQLN
HKEREELDAY IQNYKVRGIR MIVYATRVLS DKETENYKQK FNLLHSSLTN QDSLLEELAL
EYEKELNLMG MIGFKEELKS DALDFIKTVK ECNINIWLLS GDQEAQTISC AQALEMTETS
KYLRIVATEK EQIWLQINTA IGQIQSELQK IQEKQLIKQQ EKQAQQSMSR SMIKSSVTLF
EGASYQQMLQ FVLVVNGNSL SIISESPDLM SHFRFLSCVC KNVIGFNMNP QQKELACIII
KDYFPNKPTI LGVGDGYNDA LMMQASHISI EIINSKLNHI YPQVNAGDIS VNTLKEIKVL
LLQKCKLHSE RVSSMIIYLF YCAGFLGMTL FFFNWFCQFT ATSLHDSMTV FLFIFLYTTP
NALVIGLADL ETNPLVNTTI PTLYVDGQIR TKRFGFYYLI EAFLESFISA AFTFYSCTYM
VNYAWTNDGH QSDFQMVATS IIYVVITVSA LKVLFRLIQH NVHIVIIISL LTFGLLVGFV
FLNYRGNFSD FDYQELTYQL FTRFNSIVAI VFCLFGCFFI NYFLHDFIKL NIFPTVYQQF
AFINWDGTQW EDASHLHILN QCLDQHVNVS TIIQNVFIDC STTSPYISEM LNPGDTKVTE
MKLKPLTLEM KELVLEQKFL AHKLSQSLSH LRFFLCILLI YFIAYCLTDF FINDLRVFTG
VYYLIIFGIV FLILLLTCTS IMEQQYYTYS HLTVLIIFAL KVAIDWLSDD LTITLSATLV
ILFSTFNTMN MTVIPIMLYN ICYLIQLIVR ILIIVVSTDL STSNGTYTQS RISVYAACTQ
ILLVISITIR FLFTYYKSIK HRRNDYLAKY SIEQDNMTAQ DILSILVPRF VRQQISTGIY
SMQQAQDDVS ILFAYICDFD TIMKEEGKNV VLMLDSLFRL YDNLCIQHGV QKIETVGYTY
MAATGIKACE QNMTAHVIRT EKTMRLVNMA FDMMQQVQGR KYGKGNQIEM KIGIHVGRVI
AGVIGHHKPQ FSLIGDPVNQ TSRVGSTGDT GAITLSEQAF KQARHGIKYY SKKQKEAKGL
GIIDTYQVFK TKPPGYQVPK AFLLWQNCTK IVVKDLRQQR SQRQIVSKKG QFLSQLQNSI
YVDNMKQSNR LEISPKAPQT VQFLMPQNSP QEVDNKSRLS VPVQPSEAVL TDESVFMTNE
QEDNGELDLI KPNLILNIPE NEIKCNFIQI LKEQNLDESK VGIVFLWFTY FVITLLSIIV
RKLFQYNLLI FVLRAIFLIL VIVLFPILSK AYRNKLVNLM YFLLLIYAVF TVLFQAYLTD
NSEVAIICLL EILYIMIVTC QLKMFTFLQV IIYMFIMLGF FLGFYIASDL VTHFAIFYIC
CCMLILLLGY YLAMREQIQM FNNLQINEDK KVKQINLVSQ LLPMHSYLKM KNSSIYDKSD
FIDEFEDVTL LFADIKGFTE YSHTQTPEGV VTMLRNLFTE FDKLCQRYNV YKMYTIGDCY
VVMGFTNSAK RNPIQEAINT VKMGFQMVEI IMQVRLKIKF DKLNMRIGIH TGQVTGGIIG
TDIVRYDIYG KDVSIANKME SSGEEGRVQV SQTTKQMIER AEKHPFKFKF HHDVELSKFN
MSTKGYLVEW DKIRDEVSIE QQ
//
