ID A0FI88_CANLF Unreviewed; 473 AA.
AC A0FI88; E2QUL9;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=SMAP1 {ECO:0000313|EMBL:ABJ97674.1};
DE SubName: Full=Small ArfGAP 1 {ECO:0000313|Ensembl:ENSCAFP00845013483.1};
GN Name=SMAP1 {ECO:0000313|Ensembl:ENSCAFP00845013483.1};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615 {ECO:0000313|EMBL:ABJ97674.1};
RN [1] {ECO:0000313|EMBL:ABJ97674.1}
RP NUCLEOTIDE SEQUENCE.
RA Kon S., Satake M.;
RT "Dog SMAP1 protein.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCAFP00845013483.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845013483.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; DQ999010; ABJ97674.1; -; mRNA.
DR RefSeq; NP_001091027.1; NM_001097558.1.
DR STRING; 9615.ENSCAFP00000003800; -.
DR PaxDb; 9615-ENSCAFP00000003800; -.
DR Ensembl; ENSCAFT00845017301.1; ENSCAFP00845013483.1; ENSCAFG00845009742.1.
DR GeneID; 100049004; -.
DR KEGG; cfa:100049004; -.
DR CTD; 60682; -.
DR VEuPathDB; HostDB:ENSCAFG00845009742; -.
DR GeneTree; ENSGT00940000155884; -.
DR OMA; NNGWSGM; -.
DR OrthoDB; 1022106at2759; -.
DR Proteomes; UP000805418; Chromosome 12.
DR Bgee; ENSCAFG00000002612; Expressed in olfactory bulb and 47 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030276; F:clathrin binding; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:2000369; P:regulation of clathrin-dependent endocytosis; IBA:GO_Central.
DR CDD; cd08839; ArfGap_SMAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR044732; ArfGAP_SMAP1-like.
DR PANTHER; PTHR45705; FI20236P1; 1.
DR PANTHER; PTHR45705:SF8; STROMAL MEMBRANE-ASSOCIATED PROTEIN 1; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000805418};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 18..136
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 143..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 51187 MW; 2AED3F944D92D4B1 CRC64;
MATRSCREKA QKLNEQHQLI LSKLLREEDN KYCADCEAKG PRWASWNIGV FICIRCAGIH
RNLGVHISRV KSVNLDQWTP EQIQCMQDMG NTKARLLYEA NLPENFRRPQ TDQAVEFFIR
DKYEKKKYYD KNAIAITNIS SSDAPLQPLV SSPSLQATVE KNKLEKEKEK KKEEKKKEKE
PEKPVKPLTT EKLQKKEDQQ LEPKKSTSPK KAAEPTVDLL GLDGPAEAPV TNGNTTTVPS
LNDDLDIFGP MISNPLPATV IPPAQGTPSI PAAATLSTVI SGDLDLFTEQ ATKSEEVAKK
QLSKDSILSL YGTGTIQQQS TPGVFMGPTN IPFTSQAPTA FQGFPSMGVP VPAPAPAAPG
LLGNVMGQSA SMMVGMPMPN GFMGNAQTGV MPLPPNVVGP QGGMVGQMGA PQSKFGLPQA
QQPQWNLSQM NQQMAGMSIS STNPTVGFGQ PPNTTAGWSG SSSGQTLSTQ LWK
//
