ID A0JV88_ARTS2 Unreviewed; 600 AA.
AC A0JV88;
DT 12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT 12-DEC-2006, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Peptidoglycan synthetase FtsI {ECO:0000313|EMBL:ABK02958.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:ABK02958.1};
GN OrderedLocusNames=Arth_1564 {ECO:0000313|EMBL:ABK02958.1};
OS Arthrobacter sp. (strain FB24).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=290399 {ECO:0000313|EMBL:ABK02958.1, ECO:0000313|Proteomes:UP000000754};
RN [1] {ECO:0000313|Proteomes:UP000000754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FB24 {ECO:0000313|Proteomes:UP000000754};
RX PubMed=24501649; DOI=10.4056/sigs.4438185;
RA Nakatsu C.H., Barabote R., Thompson S., Bruce D., Detter C., Brettin T.,
RA Han C., Beasley F., Chen W., Konopka A., Xie G.;
RT "Complete genome sequence of Arthrobacter sp. strain FB24.";
RL Stand. Genomic Sci. 9:106-116(2013).
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP000454; ABK02958.1; -; Genomic_DNA.
DR RefSeq; WP_011691424.1; NC_008541.1.
DR AlphaFoldDB; A0JV88; -.
DR STRING; 290399.Arth_1564; -.
DR KEGG; art:Arth_1564; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_6_5_11; -.
DR Proteomes; UP000000754; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000313|EMBL:ABK02958.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000754};
KW Transferase {ECO:0000313|EMBL:ABK02958.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..225
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 271..576
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 600 AA; 64369 MW; F4A987F00D26D755 CRC64;
MAKSTGKKTT AKVPNATRRL RLGLGMMLAL LLVVGGKLFM VQGLDIGGMA EAALNNRLTP
IELPAERGSI LDANGTVLAN SVIRYNVVVD QRVNTKTESF KRLDTVGEKE ELVTVSRDKG
IQELAAVLGQ DPADVKDALT GEKPYYIVAK DLKPDMEDRI SKLQIPGIVT VGTSKRVYPN
GAVAGGIVGF LQDGTTGQAG LEQTQDEILK GTPGKRLFEI GADGLRIPVG VDELTPAVDG
KDIRLTLNSD LQYFAQQAIQ NQSDKLSAEW GVIIVQDIKT GNIIAMADTN APDPNDPGKV
AAKDRGVRSV TAAYEPGSVE KMITAASVIE EGKSSPLDHF TIPPSYVVDG QVFTDSFDHG
TEERTLAGIL GWSMNTGTVM AGQRLTKEQR HDWLQKFGIG EAPDIGLPAE ASGILTPADQ
WDGRQEYTVL FGQGVSQSTL QTVRAYQSIA NGGVMLQPRL IDSYISPDGT EEKVPAKESR
QIVSKETAKQ VRDILESAVT EGQIKDAAID GYRVGAKTGT SESPCDDGKS GYCGYTASMV
GMAPMDDPRF IVEVVLQRPK GSIYGITNGP VFRSVMSQAL RTYNVPPSTG EPVRLPQYVK
//
