ID A0JXC8_ARTS2 Unreviewed; 1166 AA.
AC A0JXC8;
DT 12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT 12-DEC-2006, sequence version 1.
DT 24-JAN-2024, entry version 104.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=Arth_2318 {ECO:0000313|EMBL:ABK03698.1};
OS Arthrobacter sp. (strain FB24).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=290399 {ECO:0000313|EMBL:ABK03698.1, ECO:0000313|Proteomes:UP000000754};
RN [1] {ECO:0000313|Proteomes:UP000000754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FB24 {ECO:0000313|Proteomes:UP000000754};
RX PubMed=24501649; DOI=10.4056/sigs.4438185;
RA Nakatsu C.H., Barabote R., Thompson S., Bruce D., Detter C., Brettin T.,
RA Han C., Beasley F., Chen W., Konopka A., Xie G.;
RT "Complete genome sequence of Arthrobacter sp. strain FB24.";
RL Stand. Genomic Sci. 9:106-116(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; CP000454; ABK03698.1; -; Genomic_DNA.
DR RefSeq; WP_011692162.1; NC_008541.1.
DR AlphaFoldDB; A0JXC8; -.
DR STRING; 290399.Arth_2318; -.
DR KEGG; art:Arth_2318; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_4_1_11; -.
DR OMA; VAKSHHW; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000000754; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07431; PHP_PolIIIA; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:ABK03698.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000754};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABK03698.1}.
FT DOMAIN 4..71
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1166 AA; 127172 MW; 3D1F4AE111A1D13B CRC64;
MSFTHLHVST AFSAHYGVSW PDELAQAAAA DGAKALACTD RDGLYGTVKH LKACMSAGLD
PVVGVDLAVF DDDGDLRTQL AGRVVVLAHG HNDGAGYRAL CRLISDAHAR TSGKAGGVVP
VAVTRAEIAS RALHPETLEP VLTVLVGPDS DVGRAMGGRR YLRPRTLFKQ WLDGMPKGTV
AAEVVSHLSA PGEALSTAHA VRMLKLAAEH GVPAVLTNAV RYCAEDGAAT ADVLDSARTL
KSLPELTAEP LLQPNGRGWL KTSAQMLELG QEIIHAAGYG ATDLTRLLGQ TEALADRCRM
DPVTDMGWKR PVVPEASVIG IAGDPLVELT LRCEAGIGRR FPGISGKPEA EMRARLEHEL
RIIANLGFAS YFLTVAEVSR MILDMGVRAA ARGSGASSLV NYLIDVSQVN PLQHDLIFER
FLSRDRATLP DIDIDVESAE RHNVYRRIFD RFGAERVTLM SMQNGYRARG AVRDAGMALG
MDDGDIGEIA KQLWRFSARN FREALVEKPE LKEFAGRVEQ RDFAENQQLD LLVDLTERLD
RLPRHISMHP CGVILGDATL LDRTPVQPSG LGLPMSQFDK HDMDPMGMLK LDVLGVRMQS
AMAFAVREVI RLHPTKAEVV AAGAHRPGPD GTGPDYIAAD GRIDLNAVPL DDEPTYELIR
STHTLGCFQI ESPGQRELIG KMAPREFNDL IIDISLFRPG PMKSDMVRPF LEHRHGFAPE
VYPHPDLKPV LQETHGVTVF HEQILKTFDV MTKCGLARAD EFRRALGNEL LEPKVEEFFR
KEARARGYTP EVVDKVWGTL KAFGSFGFCK AHGAAFAVPT YQSAWLKAHH PEAFLAGLWE
HDPGMYPKRL LVAEARRLGI PILPLDINRS HAEYRVERVG SGPDRGKLGI RLSLNGIYGL
SGAELKRIVA GQPYDSLADL RARSRLSKPS IKRLAQLGAF DTLHRESGGA ANRADLVQHL
QALQNRPSKK GVDVIEGQLS LPLGDVELRN LKAELPAPSM IDNVRAELDL MAVDVSEHLM
TSHRPLLDKL GVTTADKLLG LRNGTEVLVA GVRIATQTPP MRGGRRVVFI SIDDGTGCVD
SVFFHEAQEL AGPLLFGTRL LLIRGNTRRT GPRGISISAT MAWDLSRTET LPYPEKQSAD
PWDPALQLQG PLDGISRNLA ITGLGS
//