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Database: UniProt
Entry: A0JXC8_ARTS2
LinkDB: A0JXC8_ARTS2
Original site: A0JXC8_ARTS2 
ID   A0JXC8_ARTS2            Unreviewed;      1166 AA.
AC   A0JXC8;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   24-JAN-2024, entry version 104.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   OrderedLocusNames=Arth_2318 {ECO:0000313|EMBL:ABK03698.1};
OS   Arthrobacter sp. (strain FB24).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Arthrobacter.
OX   NCBI_TaxID=290399 {ECO:0000313|EMBL:ABK03698.1, ECO:0000313|Proteomes:UP000000754};
RN   [1] {ECO:0000313|Proteomes:UP000000754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FB24 {ECO:0000313|Proteomes:UP000000754};
RX   PubMed=24501649; DOI=10.4056/sigs.4438185;
RA   Nakatsu C.H., Barabote R., Thompson S., Bruce D., Detter C., Brettin T.,
RA   Han C., Beasley F., Chen W., Konopka A., Xie G.;
RT   "Complete genome sequence of Arthrobacter sp. strain FB24.";
RL   Stand. Genomic Sci. 9:106-116(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR   EMBL; CP000454; ABK03698.1; -; Genomic_DNA.
DR   RefSeq; WP_011692162.1; NC_008541.1.
DR   AlphaFoldDB; A0JXC8; -.
DR   STRING; 290399.Arth_2318; -.
DR   KEGG; art:Arth_2318; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_1_11; -.
DR   OMA; VAKSHHW; -.
DR   OrthoDB; 9803237at2; -.
DR   Proteomes; UP000000754; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd07431; PHP_PolIIIA; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000313|EMBL:ABK03698.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000754};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABK03698.1}.
FT   DOMAIN          4..71
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1166 AA;  127172 MW;  3D1F4AE111A1D13B CRC64;
     MSFTHLHVST AFSAHYGVSW PDELAQAAAA DGAKALACTD RDGLYGTVKH LKACMSAGLD
     PVVGVDLAVF DDDGDLRTQL AGRVVVLAHG HNDGAGYRAL CRLISDAHAR TSGKAGGVVP
     VAVTRAEIAS RALHPETLEP VLTVLVGPDS DVGRAMGGRR YLRPRTLFKQ WLDGMPKGTV
     AAEVVSHLSA PGEALSTAHA VRMLKLAAEH GVPAVLTNAV RYCAEDGAAT ADVLDSARTL
     KSLPELTAEP LLQPNGRGWL KTSAQMLELG QEIIHAAGYG ATDLTRLLGQ TEALADRCRM
     DPVTDMGWKR PVVPEASVIG IAGDPLVELT LRCEAGIGRR FPGISGKPEA EMRARLEHEL
     RIIANLGFAS YFLTVAEVSR MILDMGVRAA ARGSGASSLV NYLIDVSQVN PLQHDLIFER
     FLSRDRATLP DIDIDVESAE RHNVYRRIFD RFGAERVTLM SMQNGYRARG AVRDAGMALG
     MDDGDIGEIA KQLWRFSARN FREALVEKPE LKEFAGRVEQ RDFAENQQLD LLVDLTERLD
     RLPRHISMHP CGVILGDATL LDRTPVQPSG LGLPMSQFDK HDMDPMGMLK LDVLGVRMQS
     AMAFAVREVI RLHPTKAEVV AAGAHRPGPD GTGPDYIAAD GRIDLNAVPL DDEPTYELIR
     STHTLGCFQI ESPGQRELIG KMAPREFNDL IIDISLFRPG PMKSDMVRPF LEHRHGFAPE
     VYPHPDLKPV LQETHGVTVF HEQILKTFDV MTKCGLARAD EFRRALGNEL LEPKVEEFFR
     KEARARGYTP EVVDKVWGTL KAFGSFGFCK AHGAAFAVPT YQSAWLKAHH PEAFLAGLWE
     HDPGMYPKRL LVAEARRLGI PILPLDINRS HAEYRVERVG SGPDRGKLGI RLSLNGIYGL
     SGAELKRIVA GQPYDSLADL RARSRLSKPS IKRLAQLGAF DTLHRESGGA ANRADLVQHL
     QALQNRPSKK GVDVIEGQLS LPLGDVELRN LKAELPAPSM IDNVRAELDL MAVDVSEHLM
     TSHRPLLDKL GVTTADKLLG LRNGTEVLVA GVRIATQTPP MRGGRRVVFI SIDDGTGCVD
     SVFFHEAQEL AGPLLFGTRL LLIRGNTRRT GPRGISISAT MAWDLSRTET LPYPEKQSAD
     PWDPALQLQG PLDGISRNLA ITGLGS
//
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