ID A0KLE1_AERHH Unreviewed; 359 AA.
AC A0KLE1;
DT 12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT 12-DEC-2006, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=HBL/NHE enterotoxin family protein {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=AHA_2582 {ECO:0000313|EMBL:ABK35897.1};
OS Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC
OS 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK35897.1, ECO:0000313|Proteomes:UP000000756};
RN [1] {ECO:0000313|EMBL:ABK35897.1, ECO:0000313|Proteomes:UP000000756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 /
RC KCTC 2358 / NCIMB 9240 / NCTC 8049
RC {ECO:0000313|Proteomes:UP000000756};
RX PubMed=16980456; DOI=10.1128/JB.00621-06;
RA Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.,
RA Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL J. Bacteriol. 188:8272-8282(2006).
RN [2] {ECO:0007829|PDB:6H2F}
RP X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS).
RX PubMed=31263098; DOI=10.1038/s41467-019-10777-x;
RA Wilson J.S., Churchill-Angus A.M., Davies S.P., Sedelnikova S.E.,
RA Tzokov S.B., Rafferty J.B., Bullough P.A., Bisson C., Baker P.J.;
RT "<sup>Identification and structural analysis of the tripartite alpha-pore
RT forming toxin of Aeromonas hydrophila</sup>.";
RL Nat. Commun. 10:2900-2900(2019).
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DR EMBL; CP000462; ABK35897.1; -; Genomic_DNA.
DR RefSeq; WP_011706402.1; NC_008570.1.
DR RefSeq; YP_857092.1; NC_008570.1.
DR PDB; 6H2F; X-ray; 2.55 A; A/B/C/D/E/F/G/H/I/J=1-359.
DR PDBsum; 6H2F; -.
DR AlphaFoldDB; A0KLE1; -.
DR SMR; A0KLE1; -.
DR STRING; 380703.AHA_2582; -.
DR EnsemblBacteria; ABK35897; ABK35897; AHA_2582.
DR KEGG; aha:AHA_2582; -.
DR PATRIC; fig|380703.7.peg.2581; -.
DR eggNOG; COG0466; Bacteria.
DR HOGENOM; CLU_062822_0_0_6; -.
DR OrthoDB; 1157384at2; -.
DR Proteomes; UP000000756; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd22652; ClyA_AhlB-like; 1.
DR Gene3D; 1.20.1170.10; -; 1.
DR InterPro; IPR008414; HBL.
DR PANTHER; PTHR38443; -; 1.
DR PANTHER; PTHR38443:SF2; NON-HEMOLYTIC ENTEROTOXIN LYTIC COMPONENT L1; 1.
DR Pfam; PF05791; Bacillus_HBL; 1.
DR SUPFAM; SSF58100; Bacterial hemolysins; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:6H2F}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000756};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 177..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 359 AA; 37642 MW; BA0B5D1CDED6D9AE CRC64;
MTNATTITMD QGMANQASQA MQIQTYCNSV KQQVPVDFSQ FPNLKDNQTQ INQGLDLAKG
HADLYLNTIQ PQIITNISNI SNYFALQNAI PAVLPPGSTK AQWLRQLSVI KEQATEYQRL
SSDTRLVIVN LNNNLITDSS NFQGIVVNLN SKVQGNNGVL AQLNGDIDKV NAAIDGAIAG
IVAGGLLVIG GAFVTAIGAV ADFVTAGTST PVVIGGVAMM VAGAGGITAG AIVLHNSLGA
RQDLYQKRSS LNSEVLIATQ IGNGYKGLQV QAQNAVTAAT QMSNAWDSLT SDLGSLITDL
DKGITSGDDI RQLWLTAADT TVKTVLTDVT TIKAQMAGVS PLQVPQTDTI ANFVARLAA
//
