ID A0LHX1_SYNFM Unreviewed; 490 AA.
AC A0LHX1;
DT 12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT 12-DEC-2006, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Spermine synthase {ECO:0000313|EMBL:ABK17023.1};
GN OrderedLocusNames=Sfum_1332 {ECO:0000313|EMBL:ABK17023.1};
OS Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB).
OC Bacteria; Thermodesulfobacteriota; Syntrophobacteria; Syntrophobacterales;
OC Syntrophobacteraceae; Syntrophobacter.
OX NCBI_TaxID=335543 {ECO:0000313|EMBL:ABK17023.1, ECO:0000313|Proteomes:UP000001784};
RN [1] {ECO:0000313|EMBL:ABK17023.1, ECO:0000313|Proteomes:UP000001784}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10017 / MPOB {ECO:0000313|Proteomes:UP000001784};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G.,
RA Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R.,
RA McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J.,
RA Stams A.J.M., Worm P., Henstra A.M., Richardson P.;
RT "Complete sequence of Syntrophobacter fumaroxidans MPOB.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the spermidine/spermine synthase family.
CC {ECO:0000256|ARBA:ARBA00007867}.
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DR EMBL; CP000478; ABK17023.1; -; Genomic_DNA.
DR RefSeq; WP_011698194.1; NC_008554.1.
DR AlphaFoldDB; A0LHX1; -.
DR STRING; 335543.Sfum_1332; -.
DR KEGG; sfu:Sfum_1332; -.
DR eggNOG; COG4262; Bacteria.
DR HOGENOM; CLU_008530_1_0_7; -.
DR InParanoid; A0LHX1; -.
DR OrthoDB; 9761985at2; -.
DR Proteomes; UP000001784; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR030374; PABS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF037959; MFS_SpdSyn; 1.
DR PANTHER; PTHR43317:SF9; POLYAMINE AMINOPROPYLTRANSFERASE 2; 1.
DR PANTHER; PTHR43317; THERMOSPERMINE SYNTHASE ACAULIS5; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51006; PABS_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Polyamine biosynthesis {ECO:0000256|ARBA:ARBA00023115, ECO:0000256|PROSITE-
KW ProRule:PRU00354}; Reference proteome {ECO:0000313|Proteomes:UP000001784};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00354}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 200..442
FT /note="PABS"
FT /evidence="ECO:0000259|PROSITE:PS51006"
FT ACT_SITE 358
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00354"
SQ SEQUENCE 490 AA; 53793 MW; FCB7530FD329DB30 CRC64;
MLELIVFVCG AVVMVLEMTG SRILAPFLGT SIVVWTSLIG VILGSLSAGY WWGGRLADRN
PSHRTLAGII LVAGFCIAGI ALSKSFVLDF VQYRAGSVHL AAVLGTVVLF APSSVLLGMV
SPYAVRLKMR ALEESGRTVG NLYAISTVGS IVGTFLAGFF LIGFFGSTNI IIILSVVLAI
TSFLAYAGDR MVKISALSLF VLLLLGSQSY SGYLAGLDFH DIDTQYNRIL VYNTISMRTG
KPMRVMVTGP EGTQSGMFLD DHTELALRYT QFYPLAAHFN PRMSKVLMLG GGGYSFPKYA
LRFYPRIEMD VVELDPGVTA VARRLFALRD DPRLRIHHED ARIFLNRASG SYDVILCDTF
NSHYSIPFHL STVETVRRLF DLLADDGVVL VNTLSAIEGD RGRFLRAEVA TIKAVFPQVF
LFPVDSSTPP ERWQNVMIVA LKSPGAPRLT SADPAIAELL RHRWIGPVKE DLPILTDDYA
PVDRYVTSFP
//
