ID A0LKK9_SYNFM Unreviewed; 589 AA.
AC A0LKK9;
DT 12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT 12-DEC-2006, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Peptidase S8 and S53, subtilisin, kexin, sedolisin {ECO:0000313|EMBL:ABK17961.1};
DE Flags: Precursor;
GN OrderedLocusNames=Sfum_2279 {ECO:0000313|EMBL:ABK17961.1};
OS Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB).
OC Bacteria; Thermodesulfobacteriota; Syntrophobacteria; Syntrophobacterales;
OC Syntrophobacteraceae; Syntrophobacter.
OX NCBI_TaxID=335543 {ECO:0000313|EMBL:ABK17961.1, ECO:0000313|Proteomes:UP000001784};
RN [1] {ECO:0000313|EMBL:ABK17961.1, ECO:0000313|Proteomes:UP000001784}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10017 / MPOB {ECO:0000313|Proteomes:UP000001784};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G.,
RA Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R.,
RA McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J.,
RA Stams A.J.M., Worm P., Henstra A.M., Richardson P.;
RT "Complete sequence of Syntrophobacter fumaroxidans MPOB.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240}.
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DR EMBL; CP000478; ABK17961.1; -; Genomic_DNA.
DR RefSeq; WP_011699130.1; NC_008554.1.
DR AlphaFoldDB; A0LKK9; -.
DR STRING; 335543.Sfum_2279; -.
DR KEGG; sfu:Sfum_2279; -.
DR eggNOG; COG1404; Bacteria.
DR HOGENOM; CLU_011263_7_3_7; -.
DR InParanoid; A0LKK9; -.
DR OrthoDB; 5395460at2; -.
DR Proteomes; UP000001784; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07481; Peptidases_S8_BacillopeptidaseF-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR033857; Bacillopeptidase_F.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43399:SF5; CELL WALL-ASSOCIATED PROTEASE; 1.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000001784};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 181..484
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT REGION 384..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 190
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 243
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 424
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 589 AA; 61942 MW; 5645C966F1200B21 CRC64;
MWRALKRLAL ISAVTVFAAV WAGTGRPGAT VFIERPAKVD RLVMRKASEG KTEFLVFLAE
QADLSGAGDL ADKAQKGLYV VRALTAAAER AQGPVIEALQ SLGADFRPFW IANMIWVRGG
AEVVNAMAAR PDVARVHANP SVRLQQPFPS AAGAAPQSPA AVQWNIARVN APAVWDAGFT
GQGAVVAGQD TGYQWDHPAL KRQYRGWNGT SADHDYNWHD AVHSGGDGTC PADSPVPCDD
YGHGTHTMGT MVGDDGDADR IGMAPGARWI GCRNMDNGMG TPATYAECFQ WFIAPTRMDG
SDADPAMAPD VINNSWSCTP GEGCEDPNVL LTVVNNVRAA GILTVQSAGN AGAPCETVMD
PAAIYRASFT VGATDRSDVI ATFSSRGPVT SDGSNRRKPD ISAPGVSIRS SFKGGGYSIM
SGTSMAAPHV AGLAALLVSA NSRLSGQVDL LERIAERTAL HLVTSQGCGD DGPTDVPNNV
YGWGRIDAYA AYRRAISTGT LQVTLEPSQA VAAGGRWRVD GGPWKVDGQQ VSGLAAGGHT
VELKIVAGWK TPVVLTAVVE PGRTTRLSAV YSRPNPASWL PLLLRDGSR
//
