ID A0MN51_9CAUD Unreviewed; 703 AA.
AC A0MN51;
DT 12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT 12-DEC-2006, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=DNA polymerase {ECO:0000313|EMBL:ABJ91427.1};
GN ORFNames=YS40_033 {ECO:0000313|EMBL:ABJ91427.1}, YSP_033
GN {ECO:0000313|EMBL:BAK53551.1};
OS Thermus phage phiYS40.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes.
OX NCBI_TaxID=407392 {ECO:0000313|EMBL:ABJ91427.1, ECO:0000313|Proteomes:UP000000989};
RN [1] {ECO:0000313|EMBL:ABJ91427.1, ECO:0000313|Proteomes:UP000000989}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17027029; DOI=10.1016/j.jmb.2006.08.087;
RA Naryshkina T., Liu J., Florens L., Swanson S.K., Pavlov A.R., Pavlova N.V.,
RA Inman R., Minakhin L., Kozyavkin S.A., Washburn M., Mushegian A.,
RA Severinov K.;
RT "Thermus thermophilus bacteriophage phiYS40 genome and proteomic
RT characterization of virions.";
RL J. Mol. Biol. 364:667-677(2006).
RN [2] {ECO:0000313|Proteomes:UP000185265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22164349;
RA Tamakoshi M., Murakami A., Sugisawa M., Tsuneizumi K., Takeda S.,
RA Saheki T., Izumi T., Akiba T., Mitsuoka K., Toh H., Yamashita A.,
RA Arisaka F., Hattori M., Oshima T., Yamagishi A.;
RT "Genomic and proteomic characterization of the large Myoviridae
RT bacteriophage ?TMA of the extreme thermophile Thermus thermophilus.";
RL Bacteriophage 1:152-164(2011).
RN [3] {ECO:0000313|EMBL:BAK53551.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YS40 {ECO:0000313|EMBL:BAK53551.1};
RA Tamakoshi M., Murakami A., Sugisawa M., Tsuneizumi K., Takeda S.,
RA Saheki T., Izumi T., Akiba T., Mitsuoka K., Toh H., Yamashita A.,
RA Arisaka F., Hattori M., Oshima T., Yamagishi A.;
RT "Genomic and proteomic characterization of the large Myoviridae
RT bacteriophage phi TMA of the extreme thermophile Thermus thermophilus.";
RL Bacteriophage 1:152-164(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
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DR EMBL; DQ997624; ABJ91427.1; -; Genomic_DNA.
DR EMBL; AP011616; BAK53551.1; -; Genomic_DNA.
DR RefSeq; YP_874046.1; NC_008584.1.
DR GeneID; 4495882; -.
DR KEGG; vg:4495882; -.
DR Proteomes; UP000000989; Genome.
DR Proteomes; UP000185265; Genome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 2.
DR Pfam; PF01612; DNA_pol_A_exo1; 2.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA replication {ECO:0000256|ARBA:ARBA00023109};
KW Reference proteome {ECO:0000313|Proteomes:UP000185265};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 1..200
FT /note="3'-5' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00474"
FT DOMAIN 369..625
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT COILED 230..257
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 703 AA; 80499 MW; 89C7C24BC09A5833 CRC64;
MDKDLLGYKK IVGIDIETWD GKKGGSLDPY SGKIALVQIA YDRNNIVLYR PWEKNFEEAL
KVLSDKDVLK VGHNLKFDLK FFYMNNIYPE PIFDTMIASQ MIYAGLDEPD EISEVLEALK
DDLTTEEVAI FDVFGKKRTK ATKFSHSLQA VLKRELNIFL PKDVQNSNWG GELSEAQKEY
AINDVKYLKD LSIELWKKIK ALNIENVFML EMKFLPVLVM LELTGVKIDK EGWKKKMEKE
NQELLELEKE LKKEIYEKFV SKQSEKMMVG LFEDAEYEKI NLNSPLQMAK IFGLPNVSKL
TLEKIEDPTI KKYVEYKKKA KLVTTYSKEY LEKLTENNRL MSDYSQTKTA TGRISSSNPN
LQNVPSWFKR YITAEEGYVP VFADYSQVEL RILAYLSGDE AMIDSCNSKD MHSENARKIY
KIPPDQPVPP ELRKKAKTVS FAIPYGSSAY GLVVRGMFSS LAEAEEAIEG FFNSFPKVKE
FLEKSAKSAQ NGITRDALGR VRNYKKIYIS EDEKGALKIL MFRLPSGISK DEFIKEVLEK
NSFKDAAKIF GMDEQMLQLA ISAYEKTKKL AKIAREGQNH PIQATSASIT KTAMVDLLEY
LSMTGYGYMT LTVHDSIFFE IKKEFIFDAL PKIKEIMEQA GPKVVPGIIT PVDVEVGEKI
SVYCNSCGKE NEINRYMVNL NEKIIVDFTK DPYICDECFN RVI
//
