ID A0QSZ8_MYCS2 Unreviewed; 105 AA.
AC A0QSZ8;
DT 09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=Multidrug resistance protein, SMR family protein {ECO:0000313|EMBL:ABK71995.1};
GN OrderedLocusNames=MSMEG_1659 {ECO:0000313|EMBL:ABK71995.1};
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK71995.1, ECO:0000313|Proteomes:UP000000757};
RN [1] {ECO:0000313|EMBL:ABK71995.1, ECO:0000313|Proteomes:UP000000757}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757};
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003942};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU003942}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr
CC subfamily. {ECO:0000256|ARBA:ARBA00007822}.
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DR EMBL; CP000480; ABK71995.1; -; Genomic_DNA.
DR RefSeq; WP_011727806.1; NZ_SIJM01000023.1.
DR RefSeq; YP_886036.1; NC_008596.1.
DR AlphaFoldDB; A0QSZ8; -.
DR STRING; 246196.MSMEG_1659; -.
DR PaxDb; 246196-MSMEI_1620; -.
DR GeneID; 66733109; -.
DR KEGG; msm:MSMEG_1659; -.
DR PATRIC; fig|246196.19.peg.1644; -.
DR eggNOG; COG2076; Bacteria.
DR OrthoDB; 21828at2; -.
DR Proteomes; UP000000757; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3730.20; -; 1.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR PANTHER; PTHR30561:SF0; GUANIDINIUM EXPORTER; 1.
DR PANTHER; PTHR30561; SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000757};
KW Transmembrane {ECO:0000256|RuleBase:RU003942, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 105 AA; 10901 MW; B4222A3CCB585A9F CRC64;
MAWLILVVSG VMEAVWASAL SKSEAFTRLW PSVIFLISAP VSLVGLAVAM RTLPPGTSYS
VWVGIGASLT VGYAMLTGAE STSLIKILLI LGVVGCVIGL KVVSH
//
