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Database: UniProt
Entry: A0S0A6
LinkDB: A0S0A6
Original site: A0S0A6 
ID   A0S0A6_HUMAN            Unreviewed;       596 AA.
AC   A0S0A6;
DT   09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 1.
DT   11-DEC-2019, entry version 77.
DE   SubName: Full=Endothelial nitric oxide synthase splice variant eNOS13A {ECO:0000313|EMBL:ABB79838.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABB79838.1};
RN   [1] {ECO:0000313|EMBL:ABB79838.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17264164; DOI=10.1096/fj.06-7434com;
RA   Lorenz M., Hewing B., Hui J., Zepp A., Baumann G., Bindereif A., Stangl V.,
RA   Stangl K.;
RT   "Alternative splicing in intron 13 of the human eNOS gene: a potential
RT   mechanism for regulating eNOS activity.";
RL   FASEB J. 21:1556-1564(2007).
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DR   EMBL; DQ256129; ABB79838.1; -; mRNA.
DR   RefSeq; NP_001153581.1; NM_001160109.1.
DR   PeptideAtlas; A0S0A6; -.
DR   PRIDE; A0S0A6; -.
DR   DNASU; 4846; -.
DR   GeneID; 4846; -.
DR   CTD; 4846; -.
DR   PharmGKB; PA254; -.
DR   eggNOG; KOG1158; Eukaryota.
DR   eggNOG; COG0369; LUCA.
DR   eggNOG; COG4362; LUCA.
DR   OrthoDB; 90349at2759; -.
DR   GenomeRNAi; 4846; -.
DR   Genevisible; A0S0A6; HS.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0004517; F:nitric-oxide synthase activity; IEA:InterPro.
DR   GO; GO:0006809; P:nitric oxide biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.360; -; 1.
DR   InterPro; IPR001094; Flavdoxin-like.
DR   InterPro; IPR008254; Flavodoxin/NO_synth.
DR   InterPro; IPR029039; Flavoprotein-like_sf.
DR   InterPro; IPR004030; NOS_N.
DR   InterPro; IPR036119; NOS_N_sf.
DR   Pfam; PF00258; Flavodoxin_1; 1.
DR   Pfam; PF02898; NO_synthase; 1.
DR   PRINTS; PR00369; FLAVODOXIN.
DR   SUPFAM; SSF52218; SSF52218; 1.
DR   SUPFAM; SSF56512; SSF56512; 1.
DR   PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
DR   PROSITE; PS60001; NOS; 1.
PE   2: Evidence at transcript level;
FT   DOMAIN          520..596
FT                   /note="Flavodoxin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50902"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..65
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   596 AA;  65584 MW;  8503AC7A8B4E9C06 CRC64;
     MGNLKSVAQE PGPPCGLGLG LGLGLCGKQG PATPAPEPSR APASLLPPAP EHSPPSSPLT
     QPPEGPKFPR VKNWEVGSIT YDTLSAQAQQ DGPCTPRRCL GSLVFPRKLQ GRPSPGPPAP
     EQLLSQARDF INQYYSSIKR SGSQAHEQRL QEVEAEVAAT GTYQLRESEL VFGAKQAWRN
     APRCVGRIQW GKLQVFDARD CRSAQEMFTY ICNHIKYATN RGNLRSAITV FPQRCPGRGD
     FRIWNSQLVR YAGYRQQDGS VRGDPANVEI TELCIQHGWT PGNGRFDVLP LLLQAPDEPP
     ELFLLPPELV LEVPLEHPTL EWFAALGLRW YALPAVSNML LEIGGLEFPA APFSGWYMST
     EIGTRNLCDP HRYNILEDVA VCMDLDTRTT SSLWKDKAAV EINVAVLHSY QLAKVTIVDH
     HAATASFMKH LENEQKARGG CPADWAWIVP PISGSLTPVF HQEMVNYFLS PAFRYQPDPW
     KGSAAKGTGI TRKKTFKEVA NAVKISASLM GTVMAKRVKA TILYGSETGR AQSYAQQLGR
     LFRKAFDPRV LCMDEYDVVS LEHETLVLVV TSTFGNGDPP ENGESVSLPE VSVTTE
//
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