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Database: UniProt
Entry: A1A4L6
LinkDB: A1A4L6
Original site: A1A4L6 
ID   ETS2_BOVIN              Reviewed;         470 AA.
AC   A1A4L6;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   07-OCT-2020, entry version 80.
DE   RecName: Full=Protein C-ets-2;
GN   Name=ETS2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor activating transcription. Binds
CC       specifically the GGA DNA motif in gene promoters and stimulates
CC       transcription of those genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- PTM: Phosphorylation by CDK10 at Ser-225 may create a phosphodegron
CC       that targets ETS2 for proteasomal degradation.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
DR   EMBL; BC126692; AAI26693.1; -; mRNA.
DR   RefSeq; NP_001073683.1; NM_001080214.1.
DR   SMR; A1A4L6; -.
DR   STRING; 9913.ENSBTAP00000012144; -.
DR   PaxDb; A1A4L6; -.
DR   Ensembl; ENSBTAT00000012144; ENSBTAP00000012144; ENSBTAG00000009214.
DR   Ensembl; ENSBTAT00000074510; ENSBTAP00000072496; ENSBTAG00000009214.
DR   GeneID; 281148; -.
DR   KEGG; bta:281148; -.
DR   CTD; 2114; -.
DR   VGNC; VGNC:28627; ETS2.
DR   eggNOG; KOG3806; Eukaryota.
DR   GeneTree; ENSGT00940000160202; -.
DR   InParanoid; A1A4L6; -.
DR   KO; K21932; -.
DR   OrthoDB; 526256at2759; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   ExpressionAtlas; A1A4L6; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0042025; C:host cell nucleus; IEA:InterPro.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0001712; P:ectodermal cell fate commitment; IEA:Ensembl.
DR   GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0090009; P:primitive streak formation; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR016311; Transform_prot_C-ets.
DR   InterPro; IPR027276; Transform_prot_C-ets-2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF501032; C-ets-2; 1.
DR   PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..470
FT                   /note="Protein C-ets-2"
FT                   /id="PRO_0000287131"
FT   DOMAIN          85..170
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        364..444
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   MOD_RES         225
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P15036"
FT   MOD_RES         296
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P15036"
FT   MOD_RES         299
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P15037"
FT   MOD_RES         302
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P15037"
SQ   SEQUENCE   470 AA;  52654 MW;  A0F1364B8DACC6AA CRC64;
     MNDFGIKNMD QVAPVASSYR GTLKRQAAFD TFDGSLLAVF PSLNEEQTLQ EVPTGLDSIS
     HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP KNPWLWTEQQ VCQWLLWATN
     EFSLVDVNLQ RFGMTGQVLC NLGKERFLEL APDFVGDILW EHLEQMIKEN QEKNEDQYEE
     NSHLNSVPHW INSNSLGFGV EQAPYGMQTQ SYPKGGLLDG LCPASSAPST LGPEQDFQMF
     PKARLNTVSV NYCSVGQDFP AGSLNLLSSA SGKPRDHDSA ETGGDSFESS ESLLQSWNSQ
     SSLLDVQRVP SFESFEDDCS QSLGLSKPTM SFKDYIQDRS DPVEQGKPVI PAAVLAGFTG
     SGPIQLWQFL LELLSDKSCQ SFISWTGDGW EFKLADPDEV ARRWGKRKNK PKMNYEKLSR
     GLRYYYDKNI IHKTSGKRYV YRFVCDLQNL LGFTPEELHA ILGVQPDTED
//
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