ID A1BM01_9GAMA Unreviewed; 998 AA.
AC A1BM01;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=OvHV-2gp10 {ECO:0000313|EMBL:ABB22230.1};
OS Ovine gammaherpesvirus 2.
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Gammaherpesvirinae; Macavirus;
OC Macavirus ovinegamma2.
OX NCBI_TaxID=10398 {ECO:0000313|EMBL:ABB22230.1, ECO:0000313|Proteomes:UP000152762};
RN [1] {ECO:0000313|EMBL:ABB22230.1, ECO:0000313|Proteomes:UP000152762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17170434; DOI=10.1099/vir.0.82285-0;
RA Taus N.S., Herndon D.R., Traul D.L., Stewart J.P., Ackermann M., Li H.,
RA Knowles D.P., Lewis G.S., Brayton K.A.;
RT "Comparison of ovine herpesvirus 2 genomes isolated from domestic sheep
RT (Ovis aries) and a clinically affected cow (Bos bovis).";
RL J. Gen. Virol. 88:40-45(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; DQ198083; ABB22230.1; -; Genomic_DNA.
DR Proteomes; UP000152762; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000152762};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 174..448
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 512..979
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 998 AA; 112285 MW; 68AC2130895BEE70 CRC64;
MLSFWNPYLR GFKQPCHGTT LQVPPSYHRL VPKCLKPDEP DKHGVFSIKT SIPPTAFLGG
REVPILPGNK PSLWVNDVKL RGPDGEDLTF HVYDIVEATY SSDKCDSIPL HLQADIVPSG
IVLKLFGRTE DGRSVCVNVF GQRVYFYVHH DSYANLQRDV QHVLQESGHR SAGVHIATVH
KKFLNGYSTS SSEVRQITLW SSPAMRNLAN GLSNMGYQVF EANVDASTRF IIDNQFSTFG
WYTCSNFSAR ASDHRDSHTQ LEYDCAVGDV RFDPHRLDWP HYNILSFDIE CLGECGFPTA
DRDEDIIIQI SCAIWTVGCE SGPKLILLCV GTCAPLDGID VYEFPSEMDL LYAFFTLIRD
YGVEIITGYN ICNFDFPYVL DRARHVYNLK PEEYSKTKTN SLFYVYKPQE GNFMRAHSKV
KLSGVVVIDM YHICREKLSL SNYKLNTVAK ECMGEAKTDV TYKDIPILFR GSSHDRAKLG
LYCVQDAVLV LNLLQHFMTH IEITEIAKIA NIPPRRVITD GQQIRVFACL LAAAQEQGYI
LPMPTTGATS GYQGATVINP ISGFYNTPVL VVDFASLYPS IIQAHNLCYS TIIPHENLSN
FPDLTPNDYE TFFISSGPVH FVKKHKSESL LASLLKTWLA KRKAIRKELE QCQDEKLRAI
LDKQQLAIKV TCNSVYGFTG VASGMLPCLM IAETVTLQGR TMLEKTKQFV ENLDVQSLQQ
ICPTQTLKIH AQHPTPRFTV VYGDTDSLFI NCEGFDMDTV LEFSDRLASH TSSLLFSAPI
KLESEKVFQC LLLLTKKRYV GILSNNKILM KGVDLVRKTA CTYVQDVTRS VLELILRDSN
VKAAAQTLSQ QPVASCYKHG LPIGFLAVID ILNQSYSDLK NNRVPLARLT YSTEFSKPFS
EYKTSNLPHL AVYKKLAERN EELPQVHDRI SYVFVEASGS LVSDMAEDPN YAEQNKLPVA
SDWYFDKVIR GVANILQCLF KNDTGATVGV LYNFVKKP
//
