ID   A1C3W0_ASPCL            Unreviewed;       534 AA.
AC   A1C3W0;
DT   23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   23-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE            EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN   ORFNames=ACLA_057560 {ECO:0000313|EMBL:EAW15100.1};
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW15100.1, ECO:0000313|Proteomes:UP000006701};
RN   [1] {ECO:0000313|EMBL:EAW15100.1, ECO:0000313|Proteomes:UP000006701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC   {ECO:0000313|Proteomes:UP000006701};
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR   EMBL; DS026990; EAW15100.1; -; Genomic_DNA.
DR   RefSeq; XP_001276526.1; XM_001276525.1.
DR   AlphaFoldDB; A1C3W0; -.
DR   ESTHER; aspcl-a1c3w0; Fungal_carboxylesterase_lipase.
DR   EnsemblFungi; EAW15100; EAW15100; ACLA_057560.
DR   GeneID; 4709043; -.
DR   KEGG; act:ACLA_057560; -.
DR   VEuPathDB; FungiDB:ACLA_057560; -.
DR   eggNOG; KOG4389; Eukaryota.
DR   HOGENOM; CLU_006586_10_7_1; -.
DR   OMA; YICPGID; -.
DR   OrthoDB; 4829785at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR   PANTHER; PTHR11559:SF360; CARBOXYLIC ESTER HYDROLASE; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW   Signal {ECO:0000256|RuleBase:RU361235}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|RuleBase:RU361235"
FT   CHAIN           20..534
FT                   /note="Carboxylic ester hydrolase"
FT                   /evidence="ECO:0000256|RuleBase:RU361235"
FT                   /id="PRO_5005120954"
FT   DOMAIN          31..513
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
SQ   SEQUENCE   534 AA;  58612 MW;  2B46C748AAA1C54C CRC64;
     MRLNILYGSA LLLVPVASAL ETTVDLGYTH YRGRELSNGI VQWLGMRYAA PPLGKLRFAA
     PEDPVAAKGV QEANKHGSIC IPTGKYSVTS KKISEDCLFI DVFAPKGASR LPVFFWIQGG
     GFNVNSNANY NGTGLIKASD MGIVVVTFNY RVGPYGFLAG EEVVKGGSLN NGLKDQVKAL
     KWVQKHISKF GGDPKHVVIG GDSAGAASIT LLLSAHGGRD DGLFHAAAAE SQSFGGMLTV
     KESQFAYDNL VKRTGCGKDA DTLACLRKLD IDTLQKQNFN TPLPGAQKPP LYMYGPTIDD
     DLVPDYTYRL FHQGKFIKVP VIFGDDTNEG TIFVPKHVAD VAEADTFLQS QFPKLTPDHL
     KKINELYLKE NQTRPFPNAT SWWRPASNAY GELRYICPGI DMSAVYEKAG VKSWNYHYAV
     DDKEARTSGV GVFHTVECNA IWGPPYVNGG APKSYSTTNA PIVPVMQGYW TSFIKTFDPN
     THRARDSPEW KTWGDKGGYS RIFIKTHQTK MEQVPADQRE RCKYLTGIGV ALGQ
//