ID   A1C597_ASPCL            Unreviewed;       289 AA.
AC   A1C597;
DT   23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   23-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Metallo-beta-lactamase superfamily protein {ECO:0000313|EMBL:EAW14865.1};
GN   ORFNames=ACLA_002760 {ECO:0000313|EMBL:EAW14865.1};
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW14865.1, ECO:0000313|Proteomes:UP000006701};
RN   [1] {ECO:0000313|EMBL:EAW14865.1, ECO:0000313|Proteomes:UP000006701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC   {ECO:0000313|Proteomes:UP000006701};
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; DS027004; EAW14865.1; -; Genomic_DNA.
DR   RefSeq; XP_001276291.1; XM_001276290.1.
DR   AlphaFoldDB; A1C597; -.
DR   STRING; 344612.A1C597; -.
DR   EnsemblFungi; EAW14865; EAW14865; ACLA_002760.
DR   GeneID; 4708512; -.
DR   KEGG; act:ACLA_002760; -.
DR   VEuPathDB; FungiDB:ACLA_002760; -.
DR   eggNOG; ENOG502SIPA; Eukaryota.
DR   HOGENOM; CLU_030571_3_2_1; -.
DR   OMA; SGHAWGM; -.
DR   OrthoDB; 1433704at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd07729; AHL_lactonase_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR42978:SF2; METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR42978; QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006701}.
FT   DOMAIN          61..273
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   289 AA;  32356 MW;  51BB520F5C7061CF CRC64;
     MAVPMQQLAA ACLPAYVCPP GTKMHLLNLG TLNVDEGWLL TGGNGGTASN PNPVNKRRDL
     MLIAGLIDHP EMGLILFETG SAEDVHRQWG PVSVDLFPRT RYEEHHHLPA AIKAAGYDIK
     DVKAVIMGHL HLDHAGGLEH FRGTGVPIYV HEEEFKHACW VAATDADGGV YLADYLTLDA
     LNWQTFSESQ VDLCTGITLY HCPGHTPGLC IMQVNLKQDG TFIWTTDQFH VRENYELNQA
     QGWLLRDHRA WIESGKFIKR LQRLFSASLI FGHDYETADK LMKNKDVYE
//