GenomeNet

Database: UniProt
Entry: A1C6C4
LinkDB: A1C6C4
Original site: A1C6C4 
ID   DBP2_ASPCL              Reviewed;         549 AA.
AC   A1C6C4;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   11-DEC-2019, entry version 70.
DE   RecName: Full=ATP-dependent RNA helicase dbp2;
DE            EC=3.6.4.13;
GN   Name=dbp2; ORFNames=ACLA_069760;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: ATP-dependent RNA helicase involved nonsense-mediated mRNA
CC       decay and ribosome biogenesis through rRNA processing. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates with polysomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC       family of RNA helicases and controls ATP binding and hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX5/DBP2
CC       subfamily. {ECO:0000305}.
DR   EMBL; DS027045; EAW13945.1; -; Genomic_DNA.
DR   RefSeq; XP_001275371.1; XM_001275370.1.
DR   SMR; A1C6C4; -.
DR   STRING; 5057.CADACLAP00006953; -.
DR   PRIDE; A1C6C4; -.
DR   EnsemblFungi; EAW13945; EAW13945; ACLA_069760.
DR   GeneID; 4707597; -.
DR   KEGG; act:ACLA_069760; -.
DR   EuPathDB; FungiDB:ACLA_069760; -.
DR   HOGENOM; HOG000268804; -.
DR   KO; K12823; -.
DR   OMA; DFKNLCM; -.
DR   OrthoDB; 638613at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Helicase; Hydrolase; Nonsense-mediated mRNA decay;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN           1..549
FT                   /note="ATP-dependent RNA helicase dbp2"
FT                   /id="PRO_0000281692"
FT   DOMAIN          156..331
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          359..506
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   NP_BIND         169..176
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   MOTIF           125..153
FT                   /note="Q motif"
FT   MOTIF           279..282
FT                   /note="DEAD box"
FT   COMPBIAS        5..71
FT                   /note="Gly-rich"
FT   COMPBIAS        509..534
FT                   /note="Gly-rich"
SQ   SEQUENCE   549 AA;  59941 MW;  052B8663D195D9C0 CRC64;
     MSSYGGGYQR DSYRSRGGQG GYSNGNSYGN GGGGGGGYGG GGYGGGGFGG GGYGRGGGAA
     GGDRMSNLGA GLKKQEWDLE TLPKFEKSFY KEHPDVTARS QREVDEFRQE HKMTVQGKNV
     PRPVETFDEA GFPQYVLSEV KSQGFERPTA IQSQGWPMAL SGRDVVGIAE TGSGKTLTYC
     LPAIVHINAQ PLLAPGDGPI VLVLAPTREL AVQIQTEITK FGKSSRIRNT CVYGGVPKGP
     QIRDLSRGVE VCIATPGRLI DMLEAGRTNL RRVTYLVLDE ADRMLDMGFE PQIRKIISQI
     RPDRQTCMWS ATWPKEVRQL ASDFLNDYIQ VNIGSMDLSA NHRITQIVEV VSDFEKRDKM
     IKHLEKIMED RSNKILIFTG TKRIADEITR FLRQDGWPAL SIHGDKQQQE RDWVLNEFKA
     GKSPIMVATD VASRGIDVRD ITHVLNYDYP NNSEDYIHRI GRTGRAGAKG TAITFFTTDN
     SKQARDLVTI LTEAKQQIDP RLAEMVRYGG GGGHGHGGYG RWGGRGGGRG RGGGSTASNA
     APLGNNRRW
//
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