ID A1C6G2_ASPCL Unreviewed; 734 AA.
AC A1C6G2;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Developmental regulator FlbA {ECO:0000313|EMBL:EAW13983.1};
GN ORFNames=ACLA_070140 {ECO:0000313|EMBL:EAW13983.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW13983.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW13983.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
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DR EMBL; DS027045; EAW13983.1; -; Genomic_DNA.
DR RefSeq; XP_001275409.1; XM_001275408.1.
DR AlphaFoldDB; A1C6G2; -.
DR STRING; 344612.A1C6G2; -.
DR EnsemblFungi; EAW13983; EAW13983; ACLA_070140.
DR GeneID; 4707451; -.
DR KEGG; act:ACLA_070140; -.
DR VEuPathDB; FungiDB:ACLA_070140; -.
DR eggNOG; KOG3589; Eukaryota.
DR HOGENOM; CLU_013365_0_1_1; -.
DR OMA; DPGMRYL; -.
DR OrthoDB; 1364107at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd08708; RGS_FLBA; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10845; REGULATOR OF G PROTEIN SIGNALING; 1.
DR PANTHER; PTHR10845:SF192; RGS DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 441..527
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 560..702
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 80906 MW; 3DDA41266C9536E7 CRC64;
MPTISSTPLD QGSPPSSHHH HLLHHPHTSI TPVPVSSTPA AVHPSSSSSA SSFPPLSVPA
APPPPATTTP STTTSLWNNT NTTTTTSSFT GSVIGSISRR NRRSFAALAR EKTSNALANL
SAIGSTANSS LRTSASAGSL SKHSRKPSQI SIHEIAGLTP LTPPLSDGST SSEQSSPAYI
DYPANLSSPA VLDHHSSSID RRRQTLHRIP PLSELQSEVG SAAPPSKMHQ TSSRLLRMTE
DDRPFTKDFM DLFSTLMVSL KLDSHRVRFT KYDHSFTSEE AINNLGSLKF SQSNRMPDPK
DPSRIVTTTT TTTFSMAKEM ARSVCQRFVD ARFIEPVDGK PLPIFPLKGA LFQLTPKGIN
ILQRFCQRNG ITARHVIDVL ESPRNTMQLV NLERDTETDK LSHDRATIEV IFRRFAGQDG
PNVKNSISTS DSDSLSDYSN GLVGVKMAKE RKINEKIFMN TFTGKAAVDW LMDCSTTIER
RETVLIAELF VKYGLIMMLL EDKGYPQPDL SIVAFQPSKY AIYGITERGQ RVCGWIARDK
SRETAFYDNR GMPKDSNNAR LNHILHDPAL RLLFREFLRN SLCEENLSFY LDVSEFTATY
HKAEKLGAFK KADSVRETLA AAYGLYNAFL APGSPCELNI DHALRNSLAG RMTKAVGDDE
SMFKSLQEVV QLFEMAQTSV FKLMSSDSVP KFLRDPKYAV VLQEHDVDLI GAPRAYSPTP
APVPERSVSR SARS
//
