ID A1C7U2_ASPCL Unreviewed; 1819 AA.
AC A1C7U2;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=rRNA biogenesis protein RRP5, putative {ECO:0000313|EMBL:EAW14463.1};
GN ORFNames=ACLA_075010 {ECO:0000313|EMBL:EAW14463.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW14463.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW14463.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR EMBL; DS027045; EAW14463.1; -; Genomic_DNA.
DR RefSeq; XP_001275889.1; XM_001275888.1.
DR STRING; 344612.A1C7U2; -.
DR EnsemblFungi; EAW14463; EAW14463; ACLA_075010.
DR GeneID; 4707574; -.
DR KEGG; act:ACLA_075010; -.
DR VEuPathDB; FungiDB:ACLA_075010; -.
DR eggNOG; KOG1070; Eukaryota.
DR HOGENOM; CLU_000845_0_0_1; -.
DR OMA; GQYLRAY; -.
DR OrthoDB; 167902at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd05702; S1_Rrp5_repeat_hs11_sc8; 1.
DR CDD; cd05703; S1_Rrp5_repeat_hs12_sc9; 1.
DR CDD; cd05693; S1_Rrp5_repeat_hs1_sc1; 1.
DR CDD; cd05697; S1_Rrp5_repeat_hs5; 1.
DR CDD; cd05698; S1_Rrp5_repeat_hs6_sc5; 1.
DR CDD; cd04461; S1_Rrp5_repeat_hs8_sc7; 1.
DR CDD; cd05706; S1_Rrp5_repeat_sc10; 1.
DR CDD; cd05707; S1_Rrp5_repeat_sc11; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 11.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR045209; Rrp5.
DR InterPro; IPR048058; Rrp5_S1_rpt_hs11_sc8.
DR InterPro; IPR048059; Rrp5_S1_rpt_hs1_sc1.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR049540; Spt6-like_S1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR23270; PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5; 1.
DR PANTHER; PTHR23270:SF10; PROTEIN RRP5 HOMOLOG; 1.
DR Pfam; PF00575; S1; 4.
DR Pfam; PF21710; Spt6_S1; 1.
DR SMART; SM00386; HAT; 6.
DR SMART; SM00316; S1; 12.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 12.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50126; S1; 11.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 157..260
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 276..345
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 465..540
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 557..631
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 651..720
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 835..904
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 944..1020
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1052..1123
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1137..1206
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1231..1300
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1320..1391
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 1..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1394..1528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1421..1463
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1819 AA; 199884 MW; 6A82F22738697D8E CRC64;
MAPIKRKGNA ADQPVTRQPQ KRVRVGAEES SKDQKKQKTS ESANAPNASE LSVLRDDEPS
FPRGGGSVLT PLEKKQIHIQ ATKDVLFEQR GPKQSSGNFV DEDDDEDVEM GDADDNATST
KQSKKRKTKG KKRAEQEAKD KQGVRIEGLN FKRLVPGSMV LGQVSSINAH NIGLSLPNNL
TGYVSLTAIS KVLEDKIEKI LNDNEKEGSD AEDESDDEDS LDLKNYFYLG QYLRAYVVSV
GSNSADAPSK NKKRIELTID PRQTNTGLAK TDLELNTAVQ ASVVSVEDHG LVMDLGIEGA
NVKGFMSSKE IDFNTKYSSI KEGSVFLCMI TGQNANGSVV KLSANLQSAG SIRKSHYLST
ASTINSFLPG TAAEILLTDV SSSGLIGKIM GMLDATVDLV QSGANSGKED LAKKFQIGAK
IKGRIVCTFP SSTPFKVGFS LLDHVLRFAT EGHGPGTSED APAISAIVPE AKVVKVDPGL
GVYVKIGDTK KMGFVHVSRL ADGKVENIAP DHGPFRVDSV HEARVVGYSA LDDLYLLSYE
RKVIEQPFLR LEDVTVGAVV KGKIEKLLIG PTGVDGLIVA LADGITGLVP SMHFADAALQ
FPEKKFREGM AITARILSVN LQNRQIRLTL KKSLLNSESA IWKDYEDIVP GAQSPGTIVN
IQPHGAVVQF YGSVRGFLPV SEMSEAFIKD PSQHFRQGQV VNVHALSVDP SLGKLAVSCK
DPSTFTESYK KAFEKIQPGM LVTGTVFEKS ADDLLLKLDE FGLVARLDLA HVVDGSYPKQ
SSTLSKIRVG QKLNDLLVLD IQRARRLIKV SARASLKKAS KQGSLPAKFE DVQEGTEVTG
FVRNITADGL FVEFLGGITG LVPKRLLAEE SASKPDYGMV KSQIVTATVH SVDADFRRFI
LSMNPSELTS AGPKKPAPKP TPSNDAVANA VDESIEAMSD FTFGRTVKCK VVSVKATQVN
VQLADNVQGR IDVSEVFDEW EDIKDRKQPL RFFRPKQIIS ARILGIHDAR NHKFLPISHR
SGKFPVFELS IKPSFLEASN PTPLNLEQVQ TGSSWLGFIN NIADDCLWVN LSPNVRGRLR
FMDASDDLSL LADVEKHFPI GSALKVHVTA VDTEKGRLDL AAKQRSDKLS FSDITVGMVV
PGRVTKVTEK QVIMQLSDSI VGAVNLIDLS DDYSKADPTV YNKNEVLRAC VVGVDKANKK
ISLSLRPSKV LSSSLSVQDP EITSMKQLKV NDVVRGFVKR VADSGLFVAL GHDVTAYVRV
SDLSDSYLKE WKDSFQVDQL IKGRITLVDP EQGRLQMTLK ESALDPNYKA PVTINDLKVG
QIVTGKVRKV EEFGAFIVVD RSANISGLCH RSEMADKRVE NAKALYEEGD VVKAKIIKID
RDQGKISFSL KASHFRDDDE DESGSDEDDV SQGVSLDGME DVDFEGSDSD DDDEEGDDDE
SMGGVDLEDD SDDDEDDEDS NVEMDNAPSN RKGGLGEAGF DWSGNVRDEE DEAARSDSED
EDDSRRKKKK NRKPEIQVDR TGELDANGPQ SVADYERLLL GEPDSSLLWL QYMAFQLELG
ELEKAREIAE RALRTISLGQ DTEKLNIWVA LLNLENTYGN DDTLEEVFKR ACQYNDTQEI
YDRLTSIYIQ SGKNEKADDL FRTALKKKIS NTPKFFLNYA SFLFDSMAAP ERGRGLLPRA
LQSLPSHTHV ETTSKFAQLE FRSPNGDIER GRTVFEGLLS SFPKRIDLWN VLLDLEIKNG
DAEQVRRLFE RVLGIRDVRK GAAAPLDASK KLRPKQARFM FKKWLTFEEK LAADNGGNVK
MVEEIKAKAA DYVKSLQDA
//
