ID A1CAS0_ASPCL Unreviewed; 357 AA.
AC A1CAS0;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=Lipid droplet-associated hydrolase {ECO:0008006|Google:ProtNLM};
GN ORFNames=ACLA_012660 {ECO:0000313|EMBL:EAW12838.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW12838.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW12838.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. LDAH family.
CC {ECO:0000256|ARBA:ARBA00008300}.
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DR EMBL; DS027049; EAW12838.1; -; Genomic_DNA.
DR RefSeq; XP_001274264.1; XM_001274263.1.
DR AlphaFoldDB; A1CAS0; -.
DR ESTHER; aspcl-a1cas0; LIDHydrolase.
DR EnsemblFungi; EAW12838; EAW12838; ACLA_012660.
DR GeneID; 4706414; -.
DR KEGG; act:ACLA_012660; -.
DR VEuPathDB; FungiDB:ACLA_012660; -.
DR eggNOG; KOG3975; Eukaryota.
DR HOGENOM; CLU_018394_3_0_1; -.
DR OMA; LIGYYHT; -.
DR OrthoDB; 5474978at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0019915; P:lipid storage; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR019363; LDAH.
DR PANTHER; PTHR13390; LIPASE; 1.
DR PANTHER; PTHR13390:SF0; LIPID DROPLET-ASSOCIATED HYDROLASE; 1.
DR Pfam; PF10230; LIDHydrolase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 199..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 357 AA; 38935 MW; 92A6E365F699111A CRC64;
MSAHHRPRIT PDTFLHTVSL PNRTGPIQPS PPITIFLISG NPGLISYYHT FLSLLSEKLN
QKLKSHTTSQ VHPPSFQIYG HSLGGFALQT PQHPHPCDYD LEDQIGYVQG KLDEFLSSPE
GCGSSAAEGK SKVILIGHSV GSYIAMEILR RHRERAASAA AATAPHGSTA SFDIIGGIML
FPTVMDIAKS PSGRKLTRLL CVVPQLALVV GFLARVLVAL LPASWLRGLI RVVMGSAMPE
NAVETTAAFV QSKTGVRQAL HMAADEMRTI TADKWSDDVW GVSTADEPLA RLVFYFGRND
HWVAERTRDE IIELRGRVEG GPTMLVCEDG LPHAFCLRHN EVMAGKVADM VMDIVSE
//
