ID A1CB39_ASPCL Unreviewed; 899 AA.
AC A1CB39;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=DUF221 domain protein, putative {ECO:0000313|EMBL:EAW12957.1};
GN ORFNames=ACLA_013940 {ECO:0000313|EMBL:EAW12957.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW12957.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW12957.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS027049; EAW12957.1; -; Genomic_DNA.
DR RefSeq; XP_001274383.1; XM_001274382.1.
DR AlphaFoldDB; A1CB39; -.
DR EnsemblFungi; EAW12957; EAW12957; ACLA_013940.
DR GeneID; 4706187; -.
DR KEGG; act:ACLA_013940; -.
DR VEuPathDB; FungiDB:ACLA_013940; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_2_1_1; -.
DR OMA; DPTQVIW; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF26; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 31..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..181
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 204..402
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 417..686
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 799..891
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 738..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 243..270
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 899 AA; 100397 MW; 0EAB3E42AAEBD430 CRC64;
MGVNDAVAGL HQLTRRDDDN PQDTSNSASS LVTTLVPSLV VAVVMVLVFV ILRRSQRRMY
MPRTYLGFLR PSERSPSSRT GLWNWIVDMY KLPDEYVLQH HSMDAYLLLR FLKMITIICF
VGCLIIWPIL LPVNGTGGAG KLQLDLLSLS NIATESMARY FAHAFMAWIF VGFVFYTVTR
ESIFYINLRQ AYFLSPAYAS RLSSRTVLFT AVTEDYLNRD KIRQMFGIDK VKTVWVATDT
SELEDKVKDR DDAAMKLEAA ETKLIKLANT ERAKALKKSG NVEDDAVPLE NMAGEPDDES
GSIAARWVKP SDRPTHRLKF LIGKKVDTIN WARSEIERLT PEIEELQAKH RAGDAKLVSS
VFVEFYHQAD AQSAFQSVAH NLPLHMAPRY IGLDPTQVVW SNLRIKWWER IIRYAGTIAF
VAALVIFWAI PTAFVGSISN IDSLTNKVHF LKFINDVPGW IKGVITGLLP TVLMSVLMAL
LPIVLRLMAK LGGAPSAAAV ELTTQNFYFA FQVVQVFLVV TLASSASSVV TRIIQQPTSA
ASLLAQHIPT VSNFYISYII LQGLSFSSGA LLQITGLILG KILGKLLDST PRKMYTRWSS
LSGLGWGTVY PPLTLLAVIA ITYSCIAPLV LGFATVGLYL FYFAYRYNML YVSNADIDTQ
GKAYVRALQH ITVGCYLLVV CLIGLFAIGT ASNKVALGPM ILMIILLIFM ILYHVSLQTA
LDPLIQYLPK NLEAEEQSLL SSEPTKQSHS AGEEVDGVHA AGSGQDGENG NFASIDTAEK
GIHTAPAVIG QKPNLFIKWL RPDKYDGYWQ LRHLVPDGHE SIQYSAEVER DAYFHPSITS
QPPLLWIPRD KLGVSRQEVK HSSRVIPITD EDAWLDDKNK IHWDEDKGVP PIYEEKVYY
//
