ID A1CG31_ASPCL Unreviewed; 668 AA.
AC A1CG31;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 82.
DE SubName: Full=AIF-like mitochondrial oxidoreductase (Nfrl), putative {ECO:0000313|EMBL:EAW10911.1};
GN ORFNames=ACLA_065450 {ECO:0000313|EMBL:EAW10911.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW10911.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW10911.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00006442}.
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DR EMBL; DS027053; EAW10911.1; -; Genomic_DNA.
DR RefSeq; XP_001272337.1; XM_001272336.1.
DR AlphaFoldDB; A1CG31; -.
DR STRING; 344612.A1CG31; -.
DR EnsemblFungi; EAW10911; EAW10911; ACLA_065450.
DR GeneID; 4704666; -.
DR KEGG; act:ACLA_065450; -.
DR VEuPathDB; FungiDB:ACLA_065450; -.
DR eggNOG; KOG1336; Eukaryota.
DR HOGENOM; CLU_003291_4_2_1; -.
DR OMA; RCTHYGA; -.
DR OrthoDB; 495825at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.30.390.30; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 2.102.10.10; Rieske [2Fe-2S] iron-sulphur domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR InterPro; IPR028202; Reductase_C.
DR InterPro; IPR017941; Rieske_2Fe-2S.
DR InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR PANTHER; PTHR43557; APOPTOSIS-INDUCING FACTOR 1; 1.
DR PANTHER; PTHR43557:SF2; RIESKE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF14759; Reductase_C; 1.
DR Pfam; PF00355; Rieske; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR SUPFAM; SSF55424; FAD/NAD-linked reductases, dimerisation (C-terminal) domain; 1.
DR SUPFAM; SSF50022; ISP domain; 1.
DR PROSITE; PS51296; RIESKE; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701}.
FT DOMAIN 115..214
FT /note="Rieske"
FT /evidence="ECO:0000259|PROSITE:PS51296"
SQ SEQUENCE 668 AA; 71796 MW; 1140B896CB0B9406 CRC64;
MHLPLPRRPR ICCNPSQLQL HLQSSFSSLS SSGRSPLISS SPRRNTHCVC GCRNSAICSC
SCCVHPSSPA PSARSHTSSS LSRSAIQISS RPFSSTAPHA LARTPSTMAR EYKLKDISSL
ADIKNMDKVE SEVEGIEGGK VLVVRVGDQV HAMGSKCTHY GAPMKLGVVS PDGRITCAWH
GACFNVGTGD VEDAPAPNAL NKYEIVEKNG AVYIKGDEAA IKAGQKDAVF KCSVASPEKV
VVVGGGSGTL GLIQALRELK YKGAITIISR EPNLIIDRTK LSKALIPDPE KVQWRPKEWY
EAASIDTVFD EVTSVDFSNK TVATKSGKSF PYTKLVLATG GVPRTLPLEG FKDLGNIFLL
RFITDVQNIL KAVGDKNKKI VVVGSSFIGM EVGNALSKEN EVTIVGQEEA PMERIMGVEV
GQIFQRNLEK AGVKFKMSAG VVKATPSDSD PSKVGAVHLK DGTVLPADLV ILGVGVRPAT
DFLRDNPAVK LEKDGSIKTD DYFAVPGLNN DVFAIGDIAT YPYHGPGTDL EKGTYTRIEH
WNVAQNSGRG VARAIVHSLS TGSLQSLRPK AFIPIFWSAL GAQLRYCGNT HNGWDGLVLK
GEPMNAKFAA YYCKGDTVVA VATMGMDPIM SKCAELMRRG NMPGKKEIEE GVDVLEVEVP
PQVKMSLR
//
